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Preparation of Xia sang ju formulation

A technology for preparations of chrysanthemum chrysanthemum, which is applied in the field of preparation of chrysanthemum chrysanthemum preparations for clearing the liver and improving eyesight, and can solve the problems of high extraction temperature, large loss of aromatic volatile active ingredients, and low extraction rate of active ingredients "chlorogenic acid and pergoside" etc. problems, to achieve the effect of increasing product yield, improving product quality, and increasing the content of active ingredients

Active Publication Date: 2008-11-05
GUANGZHOU XINGQUN PHARMA
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  • Abstract
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AI Technical Summary

Problems solved by technology

Adopting this traditional extraction method has the following disadvantages: due to the high extraction temperature, the wild chrysanthemum medicinal material contains more aromatic volatile active ingredients, and the loss is large, so there is no inherent aromatic smell of wild chrysanthemum in the preparation, and the active ingredients "chlorogenic acid and Mongolian The extraction rate of flower glycosides is low

Method used

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  • Preparation of Xia sang ju formulation
  • Preparation of Xia sang ju formulation

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Experimental program
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Effect test

Embodiment 1

[0030] Embodiment 1. Preparation of Xia Sangju Granules

[0031] Take 6.4g of wild chrysanthemum, divide it into three parts 1, 2 and 3 according to the ratio of 5:3:2, put them into containers respectively, use 9.6ml of 80% ethanol as solvent, add it to the first part first, soak for 1 day, and release the liquid Transfer it to the second part, and after soaking for 1 day, transfer the effluent into the third part, and after soaking for 1 day, filter the leachate to obtain the 6.5% wild chrysanthemum flower alcohol extract. Take 500g of Prunella vulgaris, 175g of mulberry leaves, and 73.6g of wild chrysanthemum, add water to decoct twice, 1.5 hours each time, combine the decoction, filter, and concentrate the filtrate to 373ml, add 85% ethanol until the alcohol content reaches 63%, Add and stir, stand overnight for 24 hours, filter the supernatant, recover ethanol from the filtrate, concentrate under reduced pressure to 91g of extract with a relative density of 1.25 (30°C), a...

Embodiment 2

[0032] Embodiment 2. Preparation of Xia Sangju Granules

[0033] Take 7.2g of wild chrysanthemum, divide it into three parts 1, 2 and 3 according to the ratio of 6:4:3, put them into containers respectively, use 14.4ml of 90% ethanol as solvent, add it to the first part first, soak for 3 days, and release the liquid Transfer to the second part, after immersion for 3 days, transfer the discharged liquid into the third part, after 3 days of immersion, filter the leachate to obtain 9.8ml of wild chrysanthemum flower alcohol extract. Take 500g of Prunella vulgaris, 175g of mulberry leaves, and 72.8g of wild chrysanthemum, add water to decoct twice, each time for 1.5 hours, combine the decoction, filter, and concentrate the filtrate to 374ml, add 85% ethanol until the alcohol content reaches 63%, Leave to stand overnight for 24 hours, filter the supernatant, recover ethanol from the filtrate, concentrate under reduced pressure to 91g of extract with a relative density of 1.25 (30°C...

Embodiment 3

[0034] Embodiment 3. Preparation of Xia Sangju Granules

[0035] Take 8g of wild chrysanthemum, divide it into three parts 1, 2 and 3 according to the ratio of 5:3:2, put them into containers respectively, use 16ml of 95% ethanol as a solvent, add it to the first part first, soak it for 2 days, and transfer the discharged liquid into the third part. In the 2 parts, after soaking for 2 days, the released solution was transferred to the third part, and after 2 days of soaking, the leaching solution was filtered to obtain 11 ml of the alcoholic extract of wild chrysanthemum. Take 500g of Prunella vulgaris, 175g of mulberry leaves, and 72g of wild chrysanthemum, add water to decoct twice, each time for 1.5 hours, combine the decoction, filter, and concentrate the filtrate to 374ml, add 85% ethanol until the alcohol content reaches 63%, then Add and stir, let it stand overnight for 25 hours, filter the supernatant, recover ethanol from the filtrate, concentrate under reduced pressu...

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Abstract

A preparation method of a mulberry chrysanthemum preparation relates to the method of extracting active ingredients of traditional Chinese medicine, in particular to improvement of preparation method of preparing the mulberry chrysanthemum preparation. The method is as follows: 8 percent to 20 percent of the weight of wild chrysanthemum is taken, ethanol solution is used for conventional impregnation method or percolation method to extract the wild chrysanthemum ethanol extract I at 15 DEG C to 40 DEG C, the remaining wild chrysanthemum, common selfheal fruit-spike and mulberry leaf are taken, water is added for decoction, the filtration is carried out, filtrate is concentrated to obtain concentrated liquid, then ethanol is added for still placement, supernatant liquid is obtained by filtration, the ethanol is recycled from the filtrate, the pressure reducing concentration is carried out to obtain the extract, which is the water extract II, the ethanol extract I and the water extract II are merged, and pharmaceutical allowable excipients are added to prepare granules or drink or tablets. The preparation method has the following advantages: improving the content of the active ingredients of the product, the product quality, and the product yield; maintaining the unique aromatic smell of the wild chrysanthemum medicinal material. The feelings of look, smell and flavor of the prepared product are significantly better than the original mulberry chrysanthemum preparation.

Description

technical field [0001] The invention relates to a method for extracting effective components of compound Chinese medicinal materials, in particular to the improvement of the preparation method for the preparation of Xia Sangju, a medicine for clearing liver and improving eyesight. Background technique [0002] Xiasangju Granules, a medicine for clearing the liver and improving eyesight, recorded in Volume 15 of the Ministry of Health’s Drug Standards for Traditional Chinese Medicine Prescriptions, is a compound preparation prepared by extracting three Chinese herbal medicines, Prunella vulgaris, Wild Chrysanthemum, and Mulberry Leaves. It has the functions of clearing eyesight, dispelling wind and cooling, removing dampness and numbness, and detoxifying sores. It is a commonly used Chinese patent medicine for wind-heat cold, conjunctival congestion, headache, high blood pressure, dizziness and tinnitus, sore throat, and boils. The product is made of summer sangju granules af...

Claims

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Application Information

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IPC IPC(8): A61K36/605A61K9/16A61K9/20A23L2/38A23L1/29A61P27/02A61P1/16A61P11/00A61P9/12A61P1/08A61P11/04A23L33/00
Inventor 孙维广谭银合方铁铮苏广丰姚江雄许招懂符素平
Owner GUANGZHOU XINGQUN PHARMA
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