Technique for breeding experimental Macaca fascicularis without specific pathogen
A specific pathogen-free, cynomolgus monkey technology, applied in animal husbandry and other directions, can solve the problems of shortage of experimental monkeys, blindness and insecurity of experimental monkeys without specific pathogens, and achieve reliable data, small dispersion and balanced reactivity. Effect
Active Publication Date: 2008-11-12
海南金港生物技术股份有限公司
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Problems solved by technology
It takes at least 2 years to breed and raise a standard experimental cynomolgus monkey, which has caused a global shortage of experimental monkey supply. Among them, the specific pathogen-free experimental cynomolgus monkey is an experimental monkey product that is urgently needed at home and abroad.
At present, the method of obtaining specific pathogen-free experimental cynomolgus monkeys at home and abroad mostly adopts the inspection and quarantine method. This method only repeatedly isolates, inspects, quarantines and treats individual monkeys, and obtains the ultimate goal of cynomolgus monkeys through the detection method. This method obtains no Specific pathogen experimental monkeys have a certain degree of blindness and insecurity
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0008] Bacteria, including: Salmonella, Shigella, Brucella, Mycobacterium tuberculosis, skin pathogenic fungi; parasites, including: ectoparasites, Toxoplasma gondii, whole intestinal Helminths, amoebas, malaria parasites, whipworms, knot nematodes; viruses, including: B virus, simian D retrovirus, simian immunodeficiency virus, simian T cell tropism virus type I, monkeypox virus , Ebola virus, and Marburg virus microorganisms are comprehensively tested and treated accordingly. According to the ratio of 1 male to 10 females, mature male monkeys aged 5.5-8 years old and mature female monkeys aged 3.5-8 years old are selected. Separately establish a single pathogen-negative breeding population of bacteria, parasites, viruses and their subtypes, and then establish multiple pathogen-negative breeding populations, and obtain offspring standard specific pathogen-free experimental cynomolgus monkeys by artificially controlling the time of mating and conception .
[0009] The above a...
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The present invention relates to a breeding technique of an experimental animal, particularly which relates to a breeding technique of experimental cynomolgus monkey without special pathogen. The breeding technique is characterized by entirely detecting the wild monkey or self-reproduction monkey on bacteria, parasites and virus microorganism and performing corresponding therapy, establishing single pathogen feminine breeding population according to the ratio of one male and ten females, and then establishing a plurality of pathogen feminine breeding populations, establishing breeding population without special pathogen on the basis of clear population genealogy, controlling mating and fecundation time artificially to obtain filial generation standard experimental cynomolgus monkey, thus the obtained experimental cynomolgus monkey is tested to be negative on specific virus, bacteria and parasites. The breeding technique of experimental cynomolgus monkey without special pathogen solves the technical difficulty of reduplicative result of special pathogen, which has the advantages of high cleanness, good experimental repeatability, equalization reactivity, small discreteness of experimental data and more credible data.
Description
technical field [0001] The invention relates to a breeding technology of experimental animals, in particular to a breeding technology of specific pathogen-free experimental cynomolgus monkeys. Background technique [0002] Because the genetic material of experimental monkeys is as high as 98.5% homologous to humans, and its tissue structure, physiological metabolism and other functions are very similar to humans, it occupies an irreplaceable role in the research of life sciences and other related disciplines. It is known as "the most precise experimental instrument alive". Due to its high degree of cleanliness, the specific pathogen-free experimental monkey can bring more fair and objective experimental results to the experiment. It is the most high-end product among experimental animals, with a wide range of uses and high added value. [0003] Cynomolgus monkeys (Macaca fasciculares) are the second-class protected animals determined by the World Endangered Wildlife Conserv...
Claims
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Inventor 苏世华于铭苏瑞东初明明
Owner 海南金港生物技术股份有限公司