Technique for breeding experimental Macaca fascicularis without specific pathogen
A specific pathogen-free, cynomolgus monkey technology, applied in animal husbandry, etc., can solve problems such as insecurity, shortage of experimental monkey supply, blindness of experimental monkeys without specific pathogens, etc., and achieve balanced reactivity, reliable data, and small discreteness Effect
Active Publication Date: 2009-12-16
海南金港生物技术股份有限公司
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Problems solved by technology
It takes at least 2 years to breed and raise a standard experimental cynomolgus monkey, which has caused a global shortage of experimental monkey supply. Among them, the specific pathogen-free experimental cynomolgus monkey is an experimental monkey product that is urgently needed at home and abroad.
At present, the method of obtaining specific pathogen-free experimental cynomolgus monkeys at home and abroad mostly adopts the inspection and quarantine method. This method only repeatedly isolates, inspects, quarantines and treats individual monkeys, and obtains the ultimate goal of cynomolgus monkeys through the detection method. This method obtains no Specific pathogen experimental monkeys have a certain degree of blindness and insecurity
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0008] Bacteria, including: Salmonella, Shigella, Brucella, Mycobacterium tuberculosis, skin pathogenic fungi; parasites, including: ectoparasites, Toxoplasma gondii, whole intestinal Helminths, amoebas, malaria parasites, whipworms, knot nematodes; viruses, including: B virus, simian D retrovirus, simian immunodeficiency virus, simian T cell tropism virus type I, monkeypox virus , Ebola virus, and Marburg virus microorganisms are comprehensively tested and treated accordingly. According to the ratio of 1 male to 10 females, mature male monkeys aged 5.5-8 years old and mature female monkeys aged 3.5-8 years old are selected. Separately establish a single pathogen-negative breeding population of bacteria, parasites, viruses and their subtypes, and then establish multiple pathogen-negative breeding populations, and obtain offspring standard specific pathogen-free experimental cynomolgus monkeys by artificially controlling the time of mating and conception .
[0009] The above a...
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The invention relates to a breeding technology of experimental animals, in particular to a breeding technology of specific pathogen-free experimental cynomolgus monkeys. It is characterized in that: after the wild monkeys or self-breeding monkeys are fully tested for bacteria, parasites, and virus-like microorganisms and treated accordingly, a single pathogen-negative breeding population is established according to the ratio of 1 male and 10 females, and then multiple Pathogen-negative breeding populations. On the basis of a clear population lineage, a specific pathogen-free breeding population was established, and artificially controlled mating and conception time were used to obtain offspring standard experimental cynomolgus monkeys. All tested negative. It solves the technical difficulty of repeating the results of specific pathogens. It has high cleanliness, good experimental repeatability, balanced reactivity, small dispersion of experimental data, and more reliable data.
Description
technical field [0001] The invention relates to a breeding technology of experimental animals, in particular to a breeding technology of specific pathogen-free experimental cynomolgus monkeys. Background technique [0002] Because the genetic material of experimental monkeys is as high as 98.5% homologous to humans, and its tissue structure, physiological metabolism and other functions are very similar to humans, it occupies an irreplaceable role in the research of life sciences and other related disciplines. It is known as "the most precise experimental instrument alive". Due to its high degree of cleanliness, the specific pathogen-free experimental monkey can bring more fair and objective experimental results to the experiment. It is the most high-end product among experimental animals, with a wide range of uses and high added value. [0003] Cynomolgus monkeys (Macaca fasciculares) are the second-class protected animals determined by the World Endangered Wildlife Conserv...
Claims
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IPC IPC(8): A01K67/02
Inventor 苏世华于铭苏瑞东初明明
Owner 海南金港生物技术股份有限公司