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Use of modified polysaccharide rich in galactose in preparing medicine for preventing the colitis cancer

A technology of galactose and colitis, applied in the field of application of galactose-rich modified polysaccharides in the preparation of drugs to prevent colitis from becoming cancerous, and can solve problems that have not yet been retrieved

Inactive Publication Date: 2012-07-04
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether dietary fiber can prevent the transformation of inflammatory bowel disease, especially ulcerative colitis, to colon cancer, there is no research report
No reports similar to this project have been retrieved so far

Method used

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  • Use of modified polysaccharide rich in galactose in preparing medicine for preventing the colitis cancer
  • Use of modified polysaccharide rich in galactose in preparing medicine for preventing the colitis cancer
  • Use of modified polysaccharide rich in galactose in preparing medicine for preventing the colitis cancer

Examples

Experimental program
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Effect test

preparation example Construction

[0025] The preparation method of the above-mentioned modified polysaccharide rich in galactose is as follows:

[0026] The preparation method of the modified natural gum is to hydrolyze the natural gum containing galactose through polysaccharase (pH=4-5), or through alkali (pH=9-10) and acid (pH=3-5) After hydrolysis, or methanol saponification (1N NaOH, 24 hours), or sodium borohydride reduction, alcohol precipitation, dialysis, concentration, and freeze-drying, the modified natural gum was obtained. The modified natural gum is hydrolyzed by galactosidase (pH=4-6, 37° C.), alcohol precipitation, dialysis, concentration and freeze-drying. Gel chromatography or molecular weight cut-off obtains the modified natural gum containing galactose with target molecular weight (5000-50000Da). Its specific preparation method is described in detail through Examples 1-4.

[0027] The extraction method of the modified plant polysaccharide is as follows: crushing aloe vera, medlar, apple, j...

Embodiment 1

[0032] Take 100g of pectin, after slightly moistening, incubate with pectinase at 37°C for 4 hours (pH=4-6), adjust the pH value to neutral, overnight, use HPLC to detect the degree of esterification, alcohol precipitation, dialysis, and molecular weight determination. Gel chromatography or molecular weight cut-off to obtain pectin with a molecular weight of 5000-50000Da.

Embodiment 2

[0034] Take 100g of guar gum, after slightly moistening, reflux for 4 hours (pH = 9-10), adjust the pH value to neutral, overnight, and then reflux for 2 hours (pH = 3-4), alcohol precipitation, dialysis, concentration, freezing Dry. It was hydrolyzed by galactosidase (pH=4-6, 37°C), alcohol precipitation, dialysis, concentration and lyophilization. Gel chromatography or molecular weight cut-off obtains the guar gum of target molecular weight (5000-50000Da).

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Abstract

The invention relates to the application of a galactose-enriched polysaccharide to drug preparation, in particular to the application of a galactose-enriched modified polysaccharide to the preparation of drugs for preventing colonitis from cancerization. Aiming to make up the blank of the drugs for preventing the inflammatory bowel diseases and especially the ulcerative colitis from cancerization, the application provides the technical proposal that the galactose-enriched modified polysaccharide is applied to the drugs for preventing colonitis from cancerization, and the modified polysaccharide comprises a modified natural gum or a modified plant polysaccharide. The application takes galectin-3 as a medical target, and an exogenous ligand of the galectin-3 is adopted to regulate the variation of the galectin-3 and the ligand thereof and prevent the combination between the galectin-3 and the ligand thereof, thereby regulating the influence of the galectin-3 on the cell proliferation and the cell apoptosis during the development and the progression of the inflammatory bowel diseases and especially the ulcerative colitis, and achieving the purpose of preventing the inflammatory boweldiseases and especially the ulcerative colitis from cancerization.

Description

technical field [0001] The invention relates to the application of polysaccharide rich in galactose in the preparation of medicine, in particular to the application of the modified polysaccharide rich in galactose in the preparation of medicine for preventing canceration of colitis. Background technique [0002] Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a type of autoimmune disease related to immune disorders, flora disorders and genetic factors; in European and American countries, the incidence of IBD is as high as 150-200 / 100,000 [1]; in Asia, including my country's Hong Kong and Shanghai, it is showing a rapid upward trend [2]. In recent years, the intake of high-calorie, high-protein, and low-fiber foods has increased significantly in the Chinese population, and the incidence of IBD has increased year by year. At present, there is no specific drug for the treatment of IBD. IBD, especially ulcerative colitis, recurrent attacks...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/736A61P35/00
Inventor 刘莉梅其炳孙阳李宇华
Owner FOURTH MILITARY MEDICAL UNIVERSITY