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Corydalis saxicola total alkaloid, preparation method and uses thereof

A technology of total alkaloids and alkaloids, applied in the field of medicine, can solve the problems of complicated extraction process, poor stability and clarity, difficult quality of preparation products and the like, and achieve the effect of good therapeutic effect.

Inactive Publication Date: 2008-12-03
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The main problem of the statutory extraction method of total alkaloids of Litectinus chinensis (see 2002 State Drug Administration "National Compilation of Chinese Patent Medicine Standards" Internal Medicine Hepatobiliary Volume, pages 325-328) is that the intermediate process is cumbersome and leads to high-quality preparations in the later stage. (injection) difficult to control quality, poor stability and clarity
This makes the whole extraction process more cumbersome, and because a large amount of organic solvents are required in the later use of the resin method, the cost is increased, and there is a residue of toxic organic solvents in the preparation in the later stage

Method used

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  • Corydalis saxicola total alkaloid, preparation method and uses thereof
  • Corydalis saxicola total alkaloid, preparation method and uses thereof
  • Corydalis saxicola total alkaloid, preparation method and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0081] 1. Take 40Kg of the whole rock lotus plant, grind it into a coarse powder, add 400Kg of sulfuric acid aqueous solution (0.1-1%), soak and extract at room temperature for 24 hours, and filter.

[0082] 2. Take the extract, add 60Kg of common salt (NaCl) under continuous stirring, carry out salting-out, place for 10 hours, filter, collect and obtain 412g of rock yellow lotus alkaloid sulfate precipitate.

[0083] 3. Dissolve the precipitated alkaloids in 1 liter of ethanol, add 50 g of activated carbon, heat and reflux for 30 minutes to decolorize, filter, decompress and concentrate the filtrate, recover ethanol, and concentrate to obtain 301 g of dried rockwort alkaloids.

[0084] 4. Dissolve the above-obtained rockwort alkaloid in 2 liters of 20% hydrochloric acid aqueous solution, filter, and concentrate the filtrate to dryness to obtain 316 g of rockwort alkaloid hydrochloride.

specific Embodiment 2

[0085] 1. Take 80Kg of the whole rock lotus plant, grind it into a coarse powder, add 800Kg of sulfuric acid aqueous solution (0.1-1%), soak and extract at room temperature for 24 hours, and filter.

[0086] 2. Take the extract, add 120Kg of salt (NaCl) under continuous stirring, carry out salting-out, place for 10 hours, filter, collect and obtain 833g of rock yellow lotus alkaloid sulfate precipitate.

[0087] 3. Dissolve the precipitated alkaloids in 2 liters of ethanol, add 100 g of activated carbon, heat and reflux for 30 minutes to decolorize, filter, decompress and concentrate the filtrate, recover ethanol, and concentrate to obtain 635 g of dry rock lotus alkaloids.

[0088] 4. Dissolve the above-obtained rockwort alkaloid in 4 liters of 20% hydrochloric acid aqueous solution, filter, decompress and concentrate the filtrate to dryness, and obtain 641 g of rockwort alkaloid hydrochloride.

specific Embodiment 3

[0089] 1. Take 120Kg of the whole rock lotus plant, grind it into a coarse powder, add 1200Kg of sulfuric acid aqueous solution (0.1-1%), soak and extract at room temperature for 24 hours, and filter.

[0090] 2. Take the extract, add 180Kg of salt (NaCl) under continuous stirring, carry out salting-out, place for 10 hours, filter, collect and obtain 1305g of rock yellow lotus alkaloid sulfate precipitate.

[0091] 3. Dissolve the precipitated alkaloids in 3 liters of ethanol, add 150 g of activated carbon, heat and reflux for 30 minutes to decolorize, filter, decompress and concentrate the filtrate, recover ethanol, and concentrate to obtain 910 g of dried rockwort alkaloids.

[0092] 4. Dissolve the above-obtained littoria alkaloid in 6 liters of 20% hydrochloric acid aqueous solution, filter, decompress and concentrate the filtrate to dryness, and obtain 964 g of littoria alkaloid hydrochloride.

[0093] Conclusion: The above methods can be used to extract the total alkaloi...

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Abstract

The invention provides a method for extracting and preparing corydalis saxicola bunting total alkaloid, which is applied to the extraction of the corydalis saxicola bunting total alkaloid by taking corydalis saxicola bunting plants as raw materials. The method has the advantages of effectively combining unit operations of acid water extraction, salting out and active carbon decoloring and degreasing, etc.; moreover, products obtained by the method have the advantages of stable and uniform color and luster, high content of effective components and good melting property, and corydalis saxicola bunting injections prepared by the materials obtained by the method have the advantages of good clarity, high extraction yield of the corydalis saxicola bunting total alkaloid and low manufacturing cost.

Description

technical field [0001] The invention belongs to the technical field of medicines, relates to a total alkaloid of Litectin, and also relates to a preparation method of the Litectin extract and its application in preparing medicines. Background technique [0002] Corydalis thalictrifolia (Corydalis thalictrifolia Franch., Radix Corydalis Thalictrifoliae), a synonym of Corydalis thalictrifolia. Rock berberine, perennial herb, root obconical, fleshy, single or clustered stem, 15-20 cm high, leaf stem basal, leathery leaf blade, and leaf-like compound leaves, small leaves mostly 3-lobed or 3-lobed, The apex of the last lobe is round and blunt, the raceme is terminal, the capsule is linear, membranous, yellow, 2-valved when mature, the seeds are small, and grows on rocks. Distribution and Guizhou and other mountainous areas. It has the functions of clearing away heat and detoxification, promoting dampness, relieving pain and stopping bleeding. Litectin is mainly used as medicin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61P1/16
Inventor 王锦刚
Owner COSCI MED TECH CO LTD
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