Formulation of yam pills and quality control method

A quality control method and technology for yam pills, which are applied in the directions of pill delivery, pharmaceutical formulations, antipyretics, etc., can solve problems such as inconvenience in taking

Inactive Publication Date: 2009-01-21
王世锋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Prescription Nuxychnium powder is 120g, 17 flavors such as yam, crushed into fine powder about 432g, 97% is 419g, the total amount of fine powder after mixing with Nuxe seed powder is 539g, add refined honey 808.5g~916.3g , a total of 449-485 large honeyed pills of 3g were made, the maximum dosage was 2 pills per day, equivalent to 0.534g-0.495g of Nuxyche powder, which met the requirements of the daily dosage of 0.3-0.6g in the Pharmacopoeia, and the curative effect was certain , but due to the traditional dosage form of large honeyed pills, it is inconvenient to take, and is gradually eliminated. There are still quality control standards without medicinal material identification items and detection methods for strychnine content in toxic medicinal material Nuxe officinalis powder

Method used

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  • Formulation of yam pills and quality control method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: Prescription composition: Chinese yam 49.5g Eucommia (fried charcoal) 23.1g Achyranthes bidentata 33g licorice 115.5g woody 9.9g frankincense (vinegar roast) 13.2g myrrh (vinegar roast) 13.2g Qiannianjian 9.9g natural copper (calcined Vinegar quenching) 33g notopterygium 9.9g ground maple skin 9.9g safflower 9.9g Fangfeng 9.9g Dipsacus 23.1g bupleurum 13.2g dog ridge (sand hot) 33g ephedra 66g nuxe seed powder 132g.

[0021] Preparation method: the above eighteen flavors, except nuxychnium powder, seventeen flavors such as yam, crushed into fine powder, sieved, mixed, and ground with nuxy seed powder, sieved, mixed, granulated, and prepared granules, plus 6g of magnesium stearate, mixed evenly, compressed into tablets, film-coated, and made into 1000 tablets in total. The specification is 0.62g per tablet, 2 tablets each time, 2 times per mouth. It is equivalent to taking 0.528g of Nuxychnium powder per day.

Embodiment 2

[0022] Example 2: Chinese yam 33g Eucommia (fried charcoal) 15.4g Achyranthes bidentata 22g licorice 77g woody incense 6.6g frankincense (vinegar broiled) 8.8g myrrh (vinegar broiled) 8.8g Qiannianjian 6.6g natural copper (calcined vinegar quenched) 22g Qianghuo 6.6g ground maple skin 6.6g safflower 6.6g Fangfeng 6.6g Dipsacus 15.4g Bupleurum 8.8g Gouji (sand hot) 22g ephedra 44g nuxon powder 88g.

[0023] Preparation method: the above eighteen flavors, except nuxychnium powder, seventeen flavors such as yam, crushed into fine powder, sieved, mixed, and ground with nuxy seed powder, sieved, mixed, granulated, and prepared granules, add 4g of magnesium stearate, mix well, fill, and make 1000 granules altogether. The specification is 0.40g per capsule, 3 capsules each time, 2 times a day. It is equivalent to taking 0.528g of nuxe seed powder every day.

Embodiment 3

[0024] Example 3: Chinese yam 33g Eucommia (fried charcoal) 15.4g Achyranthes bidentata 22g licorice 77g woody incense 6.6g frankincense (vinegar broiled) 8.8g myrrh (vinegar broiled) 8.8g Qiannianjian 6.6g natural copper (calcined vinegar quenched) 22g Qianghuo 6.6g ground maple skin 6.6g safflower 6.6g Fangfeng 6.6g Dipsacus 15.4g Bupleurum 8.8g Gouji (sand hot) 22g ephedra 44g nuxon powder 88g.

[0025] Preparation method: the above eighteen flavors, except nuxy seed powder, seventeen flavors such as yam, crushed into fine powder, sieved, mixed, and ground with nuxy seed powder, sieved, mixed, and edible vegetable oil 220g , Macrogol 40050g, Propylene Glycol 30g are ground into paste altogether, fill and make soft capsule, make 1000 altogether. The specification is 0.70g per capsule, 3 capsules each time, 2 times a day. It is equivalent to taking 0.528g of nuxe seed powder every day.

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Abstract

The invention relates to a new preparation of a yam pill and a method for controlling the quality of the preparation. The aim of the invention is to provide a preparation method that: 45g of yam, 21g of eucommia bark (carbonizing by stir-frying), 30g of achyranthes, 105g of liquorice, 9g of aucklandia root, 12g of frankincense (vinegar prepared), 12g of myrrh (vinegar prepared), 9g of homalomena rhizome, 30g of pyritum (vinegar calcined and quenched), 9g of notopterygium root, 9g of anisetree bark, 9g of safflower, 9g of ledebouriella seseloides, 21g of radix dipsaci, 12g of radix bupleuri, 30g of rhizoma cibotii (sand scalded), 60g of Chinese ephedra, 120g of nux vomica powder and pharmaceutically acceptable accessories undergoes the necessary procedure of pulverization, uniform mixing, pellet fabrication, pill fabrication, encapsulation, tablet pressing, etc., and then prepared into pharmaceutically acceptable preparation, such as common tablets, capsules, soft capsules, watered pills, watered-honeyed pills, small honeyed pills, etc. In addition, the aim of the invention is to provide the method for controlling the quality of the preparation, and the new therapeutic applications in the aspects of cervical spondylosis, prolapse of lumbar intervertebral disc, rheumatism, rheumatoid diseases, synovitis, femoral head necrosis, acute myelitis, progressive myatrophy, myasthenia gravis and periodic paralysis.

Description

technical field [0001] The invention relates to a preparation process of a medicine, a new therapeutic application and a quality control method, in particular to a new preparation and a quality control method of yam pills. Background technique [0002] Yam Pills belong to the Ministry of Health of the People's Republic of China Drug Standards of Traditional Chinese Medicine Prescription Volume 1. The prescription consists of: Yam 45g Eucommia (fried charcoal) 21g Achyranthes bidentata 30g licorice 105g woody incense 9g frankincense (vinegar broiled) 12g myrrh ( Vinegar Sunburn) 12g Qiannianjian 9g Natural Copper (Calcined Vinegar Quenching) 30g Notopterygium 9g Dimaple Peel 9g Safflower 9g Fangfeng 9g Dipsacus 21g Bupleurum 12g Dogji (Sand Burn) 30g Ephedra 60g Nuxychnium Powder 120g. The preparation method is to crush the seventeen flavors such as yam powder into fine powder, sieve, mix, and grind with the nuxy powder, sieve, and mix. Add 150-170g of refined honey per 100g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/20A61K9/48G01N30/02G01N30/90A61P19/08A61P29/00A61P21/04A61K33/26
Inventor 王世锋
Owner 王世锋
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