Biology artificial kidney tubule bioreactor and use thereof

Abstract

The invention provides a biological reaction device which replaces human kidney, consisting of a biological reactor, a peristaltic pump, a cell culture liquid constant-flow device and a constant temperature box; the biological reactor consists of a plastic shell, a pouring liquid inlet, a pouring liquid outlet, a cell culture liquid inlet, a cell culture liquid outlet, a sulfone film nanometer supporting layer and a hollow fiber pipe; the hollow fiber pipe is arranged in a concentric round; the peristaltic pump is connected with the pouring liquid inlet and the pouring liquid outlet of the biological reactor; the constant-flow device is connected with the cell culture liquid inlet and outlet of the biological reactor; the biological reactor, the peristaltic pump and the constant-flow device are arranged inside the constant temperature box; the biological reaction device has reasonable design and simple and convenient preparation, can replace the kidney function of acute renal failure and multiple organ dysfunction syndrome patient in long-term or leads the similar patients to gradually recover the self-kidney tissue and other functions, thus improving the survival rate of the multiple organ dysfunction syndrome patient and prolonging the survival time of the multiple organ dysfunction syndrome patients.

Description

technical field [0001] The invention relates to a medical device, in particular to an artificial renal tubule bioreactor temporarily replacing human kidneys. It specifically relates to a combination with a mechanical artificial kidney, which replicates the function of renal tubules, can replace renal function for a long time, and is used for the treatment of acute renal failure and multiple organ dysfunction syndrome, thereby improving multiple organ dysfunction. Survival and Prolonged Survival of Syndrome Patients with Bioartificial Tubular Bioreactors. Background technique [0002] Regardless of acute or chronic renal failure (ARF, CRF), or multiple organ dysfunction syndrome (MODS), although the clinical causes are different, there are acute tubular necrosis (ATN), hemodialysis Therapy, although it can replace the filtering function of the glomerulus, such as removing uremic toxins in the blood, and correcting the disturbance of the patient's water and electrolyte balanc...

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiencies of the existing bioartificial renal tubule auxiliary device, and provide a bioartificial renal tubule bioreactor that replaces the human kidney. The bioreactor is composed of a plastic shell, a cell culture medium outlet, a cell culture medium inlet, a perfusate inlet, a perfusate outlet, a polysulfone membrane nanomaterial support layer, and hollow fiber tubes. The hollow fiber tubes are arranged in concentric circles, and the peristaltic pump The output end of the peristaltic pump is connected to the perfusate inlet of the bioreactor, the input end of the peristaltic pump is connected to the perfusate outlet of the bioreactor, the output end of the constant flow device is connected to the cell culture liquid inlet of the bioreactor, and the input end of the constant flow device The end is connected with the cell culture medium outlet of the bioreactor, and the bioreactor, peristaltic pump and constant flow device are placed in the incubator

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