Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical formulation for treating endometriosis symptom and processes for their preparation

A technology of endometrium and pharmaceutical preparations, applied in the field of pharmaceutical preparations for the treatment of endometriosis and its preparation, can solve the problems of patient inconvenience, long course of treatment, expensive medical expenses, etc., and achieve the reduction of estrogen level and positive curative effect , the effect of inhibiting growth

Inactive Publication Date: 2009-02-25
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the recurrence rate after surgical treatment is as high as 38%-51%, and the medical expenses are expensive, it poses a huge challenge especially to women who want to have children; although hormone therapy is effective, it can cause some side effects, such as: obesity, increased blood pressure, bone Therefore, clinical application still needs to be cautious; in recent years, traditional Chinese medicine has achieved relatively positive curative effects in the prevention and treatment of endometriosis, and most clinical reports believe that traditional Chinese medicine has the advantages of safety, effectiveness, and no or few side effects. , especially the overall conditioning effect of traditional Chinese medicine, has been valued and accepted by people
[0005] The traditional Chinese medicine for the treatment of endometriosis of the prior art is mostly based on the Chinese medicine compound that the compatibility of promoting blood circulation and removing blood stasis is made, and clinical application has different dosage forms, mostly adopts traditional decoction (Wu Tairong, Chen Yun. Taohong Siwu Decoction Treatment of 30 cases of endometriosis. Jiangsu Traditional Chinese Medicine [J]. 2002, 23 (2): 35, Zhu Zhenhua, Sun Rongrong. Modified Xiayuxue Decoction for 42 cases of endometriosis[J]. Sichuan Traditional Chinese Medicine, 2001, 19(5): 49-50), and capsules (He Jianye, Zhou Zhongquan, Huang Mingui, etc. Observation on the clinical efficacy of traditional Chinese medicine Neiyikang Capsules in the treatment of endometriosis[J]. West China Medicine, 2005, 20(3): 494-495), Granules, etc. (Wei Junying, Chen Min, Jiang Shiqing. Clinical research on the treatment of endometriosis with traditional Chinese medicine Xiaozheng Granules. Chinese Medical Journal [J], 2001, 16(5 ): 74-76.), because the decoction has many medicinal flavors, unstable curative effect, and inconvenient taking defects, which brings difficulties to clinical promotion; capsules and granules have shortcomings such as large dosage and long course of treatment (6 months), inconvenience to patients

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical formulation for treating endometriosis symptom and processes for their preparation
  • Pharmaceutical formulation for treating endometriosis symptom and processes for their preparation
  • Pharmaceutical formulation for treating endometriosis symptom and processes for their preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Get the following traditional Chinese medicine raw materials with the following weight ratio: 30g of red rattan, 15g of Puhuang, 15g of Rhizoma Cyperi, 20g of Corydalis Corydalis, 10g of paeonol, 30g of oyster, and 10g of peach kernel. Puhuang was extracted twice with 80% ethanol, adding 16 times the amount each time, refluxed for 60 minutes each time, combined the alcohol extracts, recovered the ethanol until it had no alcohol smell, centrifuged (4000r / min, 10min), and took the centrifuged liquid for future use; Puhuang Add 10 times the amount of water to soak for 40 minutes for the residue and other herbal flavors, decoct twice, add 10 times the amount of water for 45 minutes each time, filter, combine the filtrates, let stand for 24 hours, and take the supernatant for later use; Combined with water extract supernatant, concentrated in vacuum to 1.200 (60°C), spray-dried (inlet air temperature 120°C, outlet air temperature 80°C). The spray powder uses 5% HPMC in 60% e...

Embodiment 2

[0033] Get the following traditional Chinese medicine raw materials with the following weight ratio: 60g of red rattan, 30g of Puhuang, 30g of Rhizoma Cyperi, 40g of Corydalis Corydalis, 20g of paeonol, 60g of oyster, and 20g of peach kernel. Puhuang was extracted twice with 80% ethanol, adding 16 times the amount each time, refluxed for 60 minutes each time, combined the alcohol extracts, recovered the ethanol until it had no alcohol smell, centrifuged (4000r / min, 10min), and took the centrifuged liquid for future use; Puhuang Add 10 times the amount of water to soak for 40 minutes for the residue and other herbal flavors, decoct twice, add 10 times the amount of water for 45 minutes each time, filter, combine the filtrates, let stand for 24 hours, and take the supernatant for later use; Combined with water extract supernatant, concentrated in vacuum to 1.200 (60°C), spray-dried (inlet air temperature 120°C, outlet air temperature 80°C). The spray powder uses 5% HPMC in 60% e...

Embodiment 3

[0035]Get the following traditional Chinese medicine raw materials with the following weight ratio: 50g of red rattan, 20g of Puhuang, 20g of Rhizoma Cyperi, 30g of Corydalis Corydalis, 10g of paeonol, 50g of oyster, and 10g of peach kernel. Puhuang was extracted twice with 80% ethanol, adding 16 times the amount each time, refluxed for 60 minutes each time, combined the alcohol extracts, recovered the ethanol until it had no alcohol smell, centrifuged (4000r / min, 10min), and took the centrifuged liquid for future use; Puhuang Add 10 times the amount of water to soak for 40 minutes for the residue and other herbal flavors, decoct twice, add 10 times the amount of water for 45 minutes each time, filter, combine the filtrates, let stand for 24 hours, and take the supernatant for later use; Combined with water extract supernatant, concentrated in vacuum to 1.200 (60°C), spray-dried (inlet air temperature 120°C, outlet air temperature 80°C). The spray powder uses 5% HPMC in 60% et...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention pertains to the field of traditional Chinese medicine preparations, in particular to a medicine preparation for treating endometriosis and a preparation method thereof. The medicine preparation takes the traditional Chinese medicine stagnated heat theory as the basis, selects sargentodoxa cuneata, cattail pollen, yanhusuo and the like as raw materials, the alcohol extraction and the water extraction are carried out for extraction, and pharmaceutical excipients are added for preparing infusion, granules, tablets, capsules or oral liquor. The observation results of animal experiments and clinical trails prove that the medicine preparation can significantly inhibit the size of a heterotopic cyst, obviously improve the general situation and have convenient administration, good safety, affirmative efficacy and cheap price, thereby being applicable to patients with endometriosis for long-term administration.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a medicinal preparation for treating endometriosis and a preparation method thereof. Background technique [0002] Endometriosis (Endometriosis EM, referred to as endometriosis) is a frequently-occurring clinical disease in women of reproductive age, a common disease, and one of the clinical difficult diseases. So far, the etiology and pathogenesis of endometriosis have not been clarified. Over the past few years, with the changes in eating habits and living environment, the incidence of endometriosis has shown a younger and rising trend. According to relevant statistics, the incidence rate is 5%-20%. The main clinical manifestations of endometriosis are symptoms such as dysmenorrhea, infertility, and menstrual disorders, which seriously affect the life and work of patients. The concurrent endometriosis in the ovary or other parts brings great ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/8905A61P15/00A61K35/56A61K35/618
Inventor 张婷婷戴德英束兰娣秦保锋曹霖徐德生刘力
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com