Pharmaceutical formulation for treating endometriosis symptom and processes for their preparation

A technology of endometrium and pharmaceutical preparations, applied in the field of pharmaceutical preparations for the treatment of endometriosis and its preparation, can solve the problems of patient inconvenience, long course of treatment, expensive medical expenses, etc., and achieve the reduction of estrogen level and positive curative effect , the effect of inhibiting growth

Inactive Publication Date: 2009-02-25
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the recurrence rate after surgical treatment is as high as 38%-51%, and the medical expenses are expensive, it poses a huge challenge especially to women who want to have children; although hormone therapy is effective, it can cause some side effects, such as: obesity, increased blood pressure, bone Therefore, clinical application still needs to be cautious; in recent years, traditional Chinese medicine has achieved relatively positive curative effects in the prevention and treatment of endometriosis, and most clinical reports believe that traditional Chinese medicine has the advantages of safety, effectiveness, and no or few side effects. , especially the overall conditioning effect of traditional Chinese medicine, has been valued and accepted by people
[0005] The traditional Chinese medicine for the treatment of endometriosis of the prior art is mostly based on the Chinese medicine compound that the compatibility of promoting blood circulation and removing blood stasis is made, and clinical application has different dosage forms, mos

Method used

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  • Pharmaceutical formulation for treating endometriosis symptom and processes for their preparation
  • Pharmaceutical formulation for treating endometriosis symptom and processes for their preparation
  • Pharmaceutical formulation for treating endometriosis symptom and processes for their preparation

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Get the following traditional Chinese medicine raw materials with the following weight ratio: 30g of red rattan, 15g of Puhuang, 15g of Rhizoma Cyperi, 20g of Corydalis Corydalis, 10g of paeonol, 30g of oyster, and 10g of peach kernel. Puhuang was extracted twice with 80% ethanol, adding 16 times the amount each time, refluxed for 60 minutes each time, combined the alcohol extracts, recovered the ethanol until it had no alcohol smell, centrifuged (4000r / min, 10min), and took the centrifuged liquid for future use; Puhuang Add 10 times the amount of water to soak for 40 minutes for the residue and other herbal flavors, decoct twice, add 10 times the amount of water for 45 minutes each time, filter, combine the filtrates, let stand for 24 hours, and take the supernatant for later use; Combined with water extract supernatant, concentrated in vacuum to 1.200 (60°C), spray-dried (inlet air temperature 120°C, outlet air temperature 80°C). The spray powder uses 5% HPMC in 60% e...

Embodiment 2

[0033] Get the following traditional Chinese medicine raw materials with the following weight ratio: 60g of red rattan, 30g of Puhuang, 30g of Rhizoma Cyperi, 40g of Corydalis Corydalis, 20g of paeonol, 60g of oyster, and 20g of peach kernel. Puhuang was extracted twice with 80% ethanol, adding 16 times the amount each time, refluxed for 60 minutes each time, combined the alcohol extracts, recovered the ethanol until it had no alcohol smell, centrifuged (4000r / min, 10min), and took the centrifuged liquid for future use; Puhuang Add 10 times the amount of water to soak for 40 minutes for the residue and other herbal flavors, decoct twice, add 10 times the amount of water for 45 minutes each time, filter, combine the filtrates, let stand for 24 hours, and take the supernatant for later use; Combined with water extract supernatant, concentrated in vacuum to 1.200 (60°C), spray-dried (inlet air temperature 120°C, outlet air temperature 80°C). The spray powder uses 5% HPMC in 60% e...

Embodiment 3

[0035]Get the following traditional Chinese medicine raw materials with the following weight ratio: 50g of red rattan, 20g of Puhuang, 20g of Rhizoma Cyperi, 30g of Corydalis Corydalis, 10g of paeonol, 50g of oyster, and 10g of peach kernel. Puhuang was extracted twice with 80% ethanol, adding 16 times the amount each time, refluxed for 60 minutes each time, combined the alcohol extracts, recovered the ethanol until it had no alcohol smell, centrifuged (4000r / min, 10min), and took the centrifuged liquid for future use; Puhuang Add 10 times the amount of water to soak for 40 minutes for the residue and other herbal flavors, decoct twice, add 10 times the amount of water for 45 minutes each time, filter, combine the filtrates, let stand for 24 hours, and take the supernatant for later use; Combined with water extract supernatant, concentrated in vacuum to 1.200 (60°C), spray-dried (inlet air temperature 120°C, outlet air temperature 80°C). The spray powder uses 5% HPMC in 60% et...

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Abstract

The invention pertains to the field of traditional Chinese medicine preparations, in particular to a medicine preparation for treating endometriosis and a preparation method thereof. The medicine preparation takes the traditional Chinese medicine stagnated heat theory as the basis, selects sargentodoxa cuneata, cattail pollen, yanhusuo and the like as raw materials, the alcohol extraction and the water extraction are carried out for extraction, and pharmaceutical excipients are added for preparing infusion, granules, tablets, capsules or oral liquor. The observation results of animal experiments and clinical trails prove that the medicine preparation can significantly inhibit the size of a heterotopic cyst, obviously improve the general situation and have convenient administration, good safety, affirmative efficacy and cheap price, thereby being applicable to patients with endometriosis for long-term administration.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a medicinal preparation for treating endometriosis and a preparation method thereof. Background technique [0002] Endometriosis (Endometriosis EM, referred to as endometriosis) is a frequently-occurring clinical disease in women of reproductive age, a common disease, and one of the clinical difficult diseases. So far, the etiology and pathogenesis of endometriosis have not been clarified. Over the past few years, with the changes in eating habits and living environment, the incidence of endometriosis has shown a younger and rising trend. According to relevant statistics, the incidence rate is 5%-20%. The main clinical manifestations of endometriosis are symptoms such as dysmenorrhea, infertility, and menstrual disorders, which seriously affect the life and work of patients. The concurrent endometriosis in the ovary or other parts brings great ...

Claims

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Application Information

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IPC IPC(8): A61K36/8905A61P15/00A61K35/56A61K35/618
Inventor 张婷婷戴德英束兰娣秦保锋曹霖徐德生刘力
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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