Technological process for preparing beta-tricalcium phosphate micro powder by sol-gel self-propagating combustion method

Abstract

The present invention belongs to ceramic material and the preparation field thereof, and relates to a new method for preparing Beta-tricalcium phosphate micro-powders, which comprises the steps as follows: citric acid solution is dropwise added in a soluble calcium salt solution that is Ca (NO3)2, the quantity of the citric acid solution is equal to that of the Ca (NO3)2, and then (NH4)H2PO4 solution is added, so as to lead the mol ratio (nCa / nP) between calcium atoms and phosphorus atoms to be kept between 1.47 to 1.55 in the solution; diluted nitric acid is utilized to adjust until the pH value of the solution is 2 to 4, and the solution is hydrolyzed to form collosol through heating; the collosol is heated to vaporize the moisture contents until gelatin and xerogel are formed; the xerogel is moved to an electric furnace, the temperature of which is 250 to 350 DEG C, the xerogel is ignited spontaneously quickly in the electric furnace, the self-propagating combustion occurs rapidly, the volume expands, and white powders are generated. The white powders are calcined to obtain a shaggy coralloid fragile product which is mulled to obtain Beta-TCP micro-powders. The new method has the characteristics that in-situ oxidation, spontaneous combustion and the rapid synthesis of a product precursor can be implemented at lower temperature. The mixture ratio of reagents is precise, the mixing is even, the reaction velocity is high, the feed stock conversion is high, and the energy consumption is low; the product purity is high, the crystal phase is single, the average particle size is small, the distribution is even, and the hard agglomeration is less.

Description

technical field [0001] The invention belongs to the field of chemistry and biological materials, and relates to a process for preparing β-tricalcium phosphate micropowder by a sol-gel self-propagating combustion method. Background technique [0002] Calcium phosphate, mainly including hydroxyapatite, tricalcium phosphate, etc., is the main inorganic component of human hard tissues (bones, teeth). In recent years, due to the rapid development of bone tissue engineering technology and bionic technology, the research on calcium phosphate-based bioceramics has been continuously deepened. Calcium phosphate-based bioceramics has good biocompatibility, bioactivity and biodegradability, and is non-toxic, so it is considered to be the most promising modern bioceramic. and replacement, etc.) have very attractive prospects for clinical application. [0003] Compared with hydroxyapatite, the content of β-tricalcium phosphate in natural bone is lower, but the solubility of β-tricalcium...

AI Technical Summary

Problems solved by technology

Currently reported methods involving the preparation of β-TCP mainly fall into two categories, namely, wet method and dry method, both of which have their own strengths, but also have shortcomings. The main disadvantages are: high reaction temperature, high temperature heat treatment is required; The particle size of the obtained β-TCP is uneven, the average particle size is large; the crystal phase is impure; the material ratio is not easy to control accurately, the reaction time is long, and the impurity phase is easy to mix in, etc.