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Compositions and methods for treating dermatological conditions

A preparation and skin technology, applied in the field of system to treat various skin symptoms, can solve problems such as drug retention

Inactive Publication Date: 2009-03-04
NUVO RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Instead, most drugs remain on the surface of the skin for a long time, during which time they are unintentionally removed

Method used

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  • Compositions and methods for treating dermatological conditions
  • Compositions and methods for treating dermatological conditions
  • Compositions and methods for treating dermatological conditions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] [0094] As indicated, hairless mouse skin (HMS) or human epidermal membrane (HEM) were used as model membranes for the in vitro flux studies described here. Hairless mouse skin (HMS) was used as a model membrane for the in vitro flux studies described here. Freshly isolated epidermis from the abdomen of hairless mice was carefully placed between the supply and recipient compartments of the Franz diffusion cell. The receptor chamber was filled with pH 7.4 phosphate buffered saline (PBS). The experiments were initiated by placing the test formulations (Examples 2-5) on the stratum corneum (SC) of the skin samples. The Franz cell was placed on a heating stage maintained at 37°C and the temperature of the HMS was maintained at 35°C. At preset time intervals, 800 μL aliquots were aspirated and replaced with fresh PBS solution. Skin flux (μg / cm 2 / h). It should be noted that human cadaver skin can also be used as a model membrane for in vitro flux studies. The skin was p...

Embodiment 2

[0112] [0095] Acyclovir formulations in various non-volatile solvent systems were evaluated. There is an excess of aciclovir. The transdermal flux of acyclovir from the test formulations by HMS is shown in Table 1 below.

[0113] Table 1

[0114] non-volatile solvent system

skin flux ＊

(mcg / cm 2 / h) Isostearic acid 0.1±0.09 Isostearic Acid + 10% Triethanolamine 2.7±0.6 Isostearic Acid + 30% Triethanolamine 7±2 olive oil 0.3±0.2 Olive Oil + 11% Triethanolamine 3±3 Olive Oil + 30% Triethanolamine 0.3±0.2 Oleic acid 0.4±0.3 Oleic Acid + 10% Triethanolamine 3.7±0.5 Oleic Acid + 30% Triethanolamine 14±5 ethyl oleate 0.2±0.2 Ethyl Oleate + 10% Triethanolamine 0.2±0.2

[0115] * Skin flux measurements represent the mean and standard deviation of three determinations. Reported flux measurements were determined from the linear region of the cumulant versus time curve. A linear region is obser...

Embodiment 3-6

[0118] [0097] Prototype viscous curing formulations were prepared as follows. According to Table 2, prepare some acyclovir solidified preparations according to the embodiment of the present invention, as follows:

[0119] Table 2

[0120]

[0121]

[0122] * Degussa polymer

[0123][0098] In Examples 3-6, the compositions in Table 2 were prepared as follows. Eudragit RL-PO and ethanol were mixed in a glass jar and heated with stirring until the RL-PO dissolved. Isostearic acid and triethanolamine were added to the RL-PO / ethanol mixture and the mixture was stirred vigorously. Once a homogeneous mixture is obtained, acyclovir is added to the mixture and the formulation is mixed vigorously.

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Abstract

The present invention is drawn to solidifying adhesive formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug which can treat various dermatological conditions, such as a bacterial infection, a virus infection, a fungal infection, alopecia, dermatitis, psoriasis, or photo damaged skin. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system including at least one volatile solvent, and a non-volatile solvent system including at least one non-volatile solvent. The non-volatile solvent system can facilitate the delivery of the drug at therapeutically effective rates for sustained period of time. The non-volatile solvent system can also act as a plasticizer for the solidifying agent. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.

Description

field of invention [0001] [0001] The present invention generally relates to systems and methods for treating various skin conditions. More specifically, the present invention relates to an adhesive solidified formulation having a viscosity suitable for application to areas of the skin afflicted with skin disorders, and which forms an adhesive solidified layer on the skin for sustained drug delivery. Background of the invention [0002] [0002] Skin or skin conditions affect tens of thousands of people around the world. Such conditions include infections of fungal, bacterial and viral origin, alopecia, light or sun damaged skin, dermatitis and psoriasis. For each of these treatments, treatment is generally available, but current treatments have some significant disadvantages. For example, one type of viral infection is a herpes infection. Herpes infections often occur on the lips, eg, cold sores, and on the genitals. There are two common dosage forms that are used to treat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/74
CPCA61K9/7015A61K9/0014A61P17/00A61P31/12
Inventor J·张K·S·华纳S·莎玛
Owner NUVO RES
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