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Zedoary turmeric oil glucose injection and preparation method thereof

A technology of glucose injection and zedoary turmeric oil, which is applied in the fields of blood diseases, pharmaceutical formulations, extracellular fluid diseases, etc., can solve the problems such as the decrease of curcuma alcohol content and the increase of impurity absorption, so as to reduce the hidden danger of safety, increase of content, Effects of curcumitol content and pH reduction

Active Publication Date: 2009-04-29
辽宁民康制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention solves the problems that the absorption of impurities increases more and the content of curcumol decreases too quickly, and at the same time realizes terminal sterilization, which reduces the safety hazards of clinical use

Method used

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  • Zedoary turmeric oil glucose injection and preparation method thereof
  • Zedoary turmeric oil glucose injection and preparation method thereof
  • Zedoary turmeric oil glucose injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: the preparation of zedoary oil glucose injection

[0052] Take 100ml of water for injection, add 50g of glucose, add 0.15g of calcium sodium edetate, stir to dissolve, add 0.1g of activated carbon, boil for 15 minutes, filter to obtain solution 1; take 0.4g of curcuma oil (taking curcumol as 100% Feeding), add 0.08g of vitamin E, stir well, add Tween-802.0g, stir well; take 100ml of water for injection, slowly add the mixture of zedoary oil and Tween-80, stir well, to get solution 2; Mix solution 1 and solution 2, add water for injection to 1000ml, adjust pH to 4.0-5.0 with 10% citric acid solution, filter, fill, cap, and sterilize at 121°C for 8 minutes to obtain curcuma oil glucose injection Liquid A.

Embodiment 2

[0053] Embodiment 2: the preparation of zedoary oil glucose injection

[0054] Take 200ml of water for injection, add 100g of glucose, add 0.1g of calcium sodium edetate, stir to dissolve, add 0.4g of activated carbon, boil for 30 minutes, filter to obtain solution 1; take 0.3g of turmeric oil, add 0.5g of vitamin E, stir Evenly, add Tween-801.5g, stir well; take an appropriate amount of water for injection, slowly add it to the mixture of zedoary oil and Tween-80, stir well to obtain solution 2; mix solution 1 and solution 2, add Add water for injection to 1000ml, adjust pH to 4.0-5.0 with 20% citric acid solution, filter, fill, cap, and sterilize at 115°C for 30 minutes to obtain Zedoary Oil Glucose Injection.

Embodiment 3

[0055] Embodiment 3: the preparation of zedoary oil glucose injection

[0056] Take 80ml of water for injection, add 50g of glucose, add 0.2g of calcium sodium edetate, stir to dissolve, add 0.04g of activated carbon, boil for 5 minutes, filter to obtain solution 1; take 0.5g of zedoary oil, add 0.01g of vitamin E, stir Mix well, add Tween-803.0g, stir well; take appropriate amount of water for injection, slowly add the mixture of zedoary oil and Tween-80, stir well to get solution 2; mix solution 1 and solution 2, add injection Water to 1000ml, adjust the pH to 4.0-5.0 with 1% citric acid solution, filter, fill, cap, and sterilize at 121°C for 8 minutes to obtain Curcuma Oil Glucose Injection.

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Abstract

The invention relates to a turmeric oil and glucose injection which is prepared by the following method: proper injection water is taken and glucose is added to prepare a liquid with certain concentration; then mosatil is added and stirred for dissolving; proper active carbon is added and boiled for a certain time and then filtered; then turmeric oil is additionally taken and proper vitamin E is added, fully stirred and added into Tween-80; proper injection water is taken; the mixed liquor of the turmeric oil and the Tween-80 is slowly added and continuously heated to a certain temperature and stirred until the mixed liquor is milky white. The turmeric oil liquor is mixed with the glucose liquor; the injection water is added until the full dose; the pH is regulated by citric acid liquor and the mixed liquor is stirred for a certain time, filtered, filled and sterilized by a terminal. The medicine composition and the preparation method thereof can obtain the stable turmeric oil and glucose injection, are better than the prior art, ensure the safety of clinical application and can reduce the safety risk.

Description

field of invention [0001] The invention relates to an injection preparation, in particular to an zedoary oil glucose injection and a preparation method thereof. Background technique [0002] Zedoary oil is the volatile oil extracted from the Zingiberaceae plant Curcuma, Curcuma or Guangxi Zedoary Rhizome. Pharmacological studies have shown that Zedoary Oil has anti-virus, anti-bacterial, anti-tumor, anti-thrombosis, liver protection, treatment of psoriasis, cervical erosion, digestion Ulcers, and enhance immune function and so on. Zedoary oil glucose injection is a sterilized aqueous solution made of zedoary oil, glucose and a suitable cosolvent, wherein the cosolvent is polysorbate 80 (Tween-80), but when used as an injection, Tween-80 has certain toxicity and Hemolysis (Heilongjiang Medical Science, 2001, 24(4): 40), at the same time, it can also increase the absorption of impurities in zedoary oil and glucose injection, and during the storage process, the curcumol conten...

Claims

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Application Information

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IPC IPC(8): A61K36/906A61K47/26A61K47/34A61P1/04A61P1/16A61P7/02A61P15/00A61P17/06A61P31/04A61P31/12A61P35/00A61P37/04
Inventor 赵同华张宏宇梁隆程志鹏
Owner 辽宁民康制药有限公司
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