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Preparation method of chinese medicine granule containing dalbergia heartwood oil

A technology of traditional Chinese medicine granules and balm oil, applied in the direction of block transportation, etc., can solve the problems of unsightly appearance, poor taste, and low drug loading of granules

Active Publication Date: 2012-04-18
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Several common granule preparation processes and their existing defects: 1. Traditional granule preparation process, due to the high viscosity of traditional Chinese medicine extracts, most of the traditional granule preparation methods have low drug loading, unsightly appearance, and poor taste , easy to absorb moisture and other problems
5. In the field of preparations, there are also fluidized bed bottom spraying or side spraying techniques to manufacture western medicine pellets or spherical granules, which are mostly used in the development of sustained release preparations. Therefore, the developed products generally have slow and controlled release characteristics, and do not have immediate release characteristics.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Preparation of the active ingredient of the present invention:

[0077] Salvia miltiorrhiza extract: obtained according to the preparation method of Chinese patent application (application number 02117923.9). The specific extraction method is as follows: 5 kg of Salvia miltiorrhiza is pulverized into coarse powder, and deionized water is added to heat and extract 3 times under a slight boiling state at 100°C. The first time is 5.5 times the water, heating for 1 hour; the second and the third time each adding 3 times the amount of water and heating for 0.5 hours. After the extract was adjusted to pH 2 with 10% hydrochloric acid, it was filtered, and the filtrate was applied to a polyamide column (the dry resin amount is 2 / 3 of the crude drug amount). Wash with 5 times the amount of deionized water, and continue to wash with 0.1% sodium bicarbonate aqueous solution, the amount is 5 times the column volume. Collect the eluent, adjust the pH to 2 with 10% hydrochloric acid, ...

Embodiment 2

[0085] Preparation of the active ingredients of the present invention: Take 1000 g of Salvia miltiorrhiza extract in Example 1, 2000 g of Panax notoginseng extract in Example 1, 750 g of Astragalus membranaceus extract in Example 1, and 300 g of Dalbergia odorifera oil in Example 1. Ingredients

[0086] Preparation of masterbatch: take a mixture of micronized silica gel and chitosan with a weight ratio of 1:1 and pass it through a 200-mesh sieve, of which 65% is used as the bottom material and put into the spray pot on the side of the fluidized bed, and PVP K30 is added with water, extract, and preparation Viscosity-forming agent-sprayed as a slurry, and screened out small particles with a particle size of 120-180μ as the mother core, and then put the mother core into the pot, continue to spray the starch slurry, while the remaining 35% from the powder gun The fine powder of silica gel and chitosan is sprinkled in to increase the particle size of the core, and the masterbatch wit...

Embodiment 3

[0089] Preparation of the active ingredients of the present invention: Take 960 g of Salvia miltiorrhiza extract in Example 1, 1360 g of Panax notoginseng extract in Example 1, 700 g of Astragalus extract in Example 1, and 280 g of Dalbergia odorifera oil in Example 1 and mix them uniformly to prepare.

[0090] Preparation of masterbatch: take a mixture of dextrin and starch with a weight ratio of 1:1 and pass it through a 200-mesh sieve, of which 65% is used as the bottom material into the spray pot on the side of the fluidized bed, and the starch and extract are taken separately 15% of the weight of the granules) and spray it into the slurry with water, and sift out small particles (with a particle size of 180-250μ) as the mother core, and then put the mother core into the pot, continue to spray the starch slurry, and at the same time from the powder gun Sprinkle the remaining 35% dextrin and starch fine powder to increase the particle size of the core, and select the masterbatc...

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PUM

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Abstract

The invention provides a preparation method of traditional Chinese medicine granular with dalbergia wood oil. Traditional Chinese medicine spheroidized particles are prepared by using a traditional Chinese medicine extract and a pharmaceutically acceptable carrier. The shapes of the traditional Chinese medicine spheroidized particles are spherical or similar to spheres, and the density of the traditional Chinese medicine spheroidized particles ranges from 0.6 g / ml to 1.3 g / ml. A single dose of the spheroidized particles is small, the medicine taking is convenient, and the granular preparation can be used as a semifinished product of capsules and can also be used for developing sustained and controlled release preparations of traditional Chinese medicine.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a traditional Chinese medicine granule containing dalbergia oil and a preparation method thereof. Background technique [0002] According to my country's epidemiological survey, the incidence and mortality of cardiovascular and cerebrovascular diseases have been on the rise in the past 50 years, whether in rural or urban areas. In the 1950s and 1960s, cardiovascular disease and cerebrovascular disease ranked fifth and sixth respectively among the causes of death in our country. After 1975, they rose to the second and third places. Cardiovascular and cerebrovascular diseases accounted for the first cause of death. The percentage of deaths due to cardiovascular and cerebrovascular diseases in my country has risen from 12.07% in 1957 to 42.6% in 2001. There are 2 million deaths from cardiovascular and cerebrovascular diseases each year. Some p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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