Method for preparing hypertension mouse model

Abstract

Gestational hypertension relates to a specific disease in the gestation period. The invention establishes an appropriate animal model for imitating the gestational hypertension sign of human, and facilitates knowing the occurrence and the development process of pathology of the gestational hypertension sign, understanding nosetiological factors relevant to the gestational hypertension sign, and establishing a clinical diagnosis index, so that the invention has great significance for screening treatment medicines, and the invention is also favorable for researching the influence of the gestational hypertension sign for growth of the filial generation in detail and provides experiment references for intervening treatment in advance. The invention provides a method for preparing an animal model used for hypertension nosogenesis and a treatment method thereof through chill stimulation, which is used for establishing the gestational hypertension mouse model with stability, convenience and reasonable cost, so as to smoothly perform the research of nosogenesis and the treatment method of the disease.

Description

technical field [0001] The invention relates to a method for preparing a mouse model of hypertension. In particular, it relates to a method for preparing an animal model for studying the pathogenesis and treatment of hypertension through cold stimulation. Background technique [0002] Gestational hypertension is a disease unique to pregnancy, mainly manifested as hypertension, edema, and proteinuria after 20 weeks of pregnancy. Severe cases have subjective symptoms such as headache, dizziness, and vertigo, and even convulsions and coma. Blood pressure usually returns to normal after pregnancy. In my country, the incidence rate is 5-8%. It is one of the three major causes of death in pregnancy and puerpera, and it is also one of the causes of fetal intrauterine growth retardation and infant death. The pathological basis of pregnancy-induced hypertension is still unclear. In the past 50 years, the incidence and treatment of pregnancy-induced hypertension have not changed fu...

AI Technical Summary

Problems solved by technology

The hypertensive models formed by surgery generally use dogs, rabbits, and rats, and the success rate is high, but the operation is more cumbersome, and the operator needs to have certain skills, and the number of animals obtained is limited

The drug-induced hypertension model uses more drugs such as deoxycorticosterone acetate, L-nitroarginine methyl ester, insulin, doxorubicin, streptozotocin, etc., in the study of the pathogenesis of pregnancy-induced hypertension Some success has been achieved with regard to the effects of gestational hypertension and pregnancy-induced hypertension on fetal development, but the drug may also adversely affect pregnancy

The transgenic or gene mutation hypertension model prepared by genetic modification is actually not suitable for studying the pathology of natural pregnancy-induced hypertension and the influence of pregnancy-induced hypertension on fetal development due to the heritability of the gene that causes hypertension

[0006] It should be pointed out that each model of pregnancy-induced hypertension mentioned above is mainly characterized by the study of hypertension, and it cannot fully simulate all aspects of human pregnancy-induced hypertension