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Nano calcium phosphate salt/polymer directional hole composite material and preparation method

A nano-calcium phosphate and composite material technology, which is applied in the field of antibiotic drug carrier materials and preparation, can solve the problems of lack of performance antibiotic carrier materials, and achieve the effect of avoiding pain and reducing economic burden

Inactive Publication Date: 2009-07-22
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the research on inorganic / organic composite porous materials has achieved remarkable results, the materials currently prepared are still difficult to meet various requirements. There is still a lack of antibiotic carrier materials with good performance in the process

Method used

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  • Nano calcium phosphate salt/polymer directional hole composite material and preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Calcium acetate (CH 3 COO) 2 Ca) and phosphoric acid (H 3 PO 4 ) as precursors of calcium and phosphorus respectively, 21.3927 g (CH 3 COO) 2 Ca was dispersed in 100 ml of absolute ethanol system, and then 9.8 g of H was added dropwise under vigorous stirring. 3 PO 4 , the solution was adjusted to pH ≥ 9 with 5 mol / L NaOH, stirred at 30°C for 12 hours to form a stable milky white sol, then filtered and dried at 80°C for 12 hours, collected and ground to obtain Tricalcium phosphate powder with an average particle size of 80 nm.

[0023] Dissolve 5 grams of polycaprolactone with a molecular weight of 70,000 in 20 milliliters of tetrahydrofuran, add 1 gram of surfactant Span80 and 2 milliliters of water, and then add 1 gram of tricalcium phosphate obtained by the above method under vigorous stirring at 30°C Nano powder, continue to stir at high speed for 10 hours to form a metastable colloidal system; inject the colloid into a 15ml plastic centrifuge tube with a con...

Embodiment 2

[0025] The preparation of the tricalcium phosphate nanopowder is the same as in Example 1.

[0026] Dissolve 5 grams of polycaprolactone with a molecular weight of 70000 in 20 milliliters of tetrahydrofuran, add 1 gram of surfactant Span80 and 2 milliliters of water, then add 1 gram of tricalcium phosphate nanopowder under vigorous stirring at 30°C, Continue high-speed stirring for 10 hours to form a metastable colloidal system; inject the colloid into a 15 ml plastic centrifuge tube with a conical bottom, clamp it on a device that can precisely control the lifting rate, and expose the bottom of the plastic centrifuge tube to liquid nitrogen The liquid level then drops at a rate of 50 mm / h until the colloid is completely submerged in liquid nitrogen, then stops falling and maintains this state for 3 hours, and freeze-dries for 72 hours after taking it out to obtain a nano-phosphate triphosphate with an average pore size of 3 microns. Calcium / Polycaprolactone Oriented Pore Comp...

Embodiment 3

[0028] The preparation of the tricalcium phosphate nanopowder is the same as in Example 1.

[0029] Dissolve 5 grams of polycaprolactone with a molecular weight of 70000 in 20 milliliters of tetrahydrofuran, add 1 gram of surfactant Span80 and 2 milliliters of water, then add 1 gram of tricalcium phosphate nanopowder under vigorous stirring at 30°C, Continue high-speed stirring for 10 hours to form a metastable colloidal system; inject the colloid into a 15 ml plastic centrifuge tube with a conical bottom, clamp it on a device that can precisely control the lifting rate, and then expose the bottom of the plastic centrifuge tube to liquid nitrogen The liquid level then drops at a rate of 100 mm / hour until the colloid is completely submerged in liquid nitrogen, then stops falling and maintains this state for 3 hours, and freeze-dries for 72 hours after taking it out to obtain a nano-phosphate triphosphate with an average pore size of 5 microns. Calcium / Polycaprolactone Oriented ...

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Abstract

The invention provides a nano calcium phosphate / polymer directional hole composite material and a preparation method thereof, which relate to an antibiotic medical vector material and a preparation method thereof. The nano calcium phosphate / polymer directional hole composite material consists of nano calcium phosphate, polymers and a directional hole structure, wherein the directional hole structure is that tubular holes are directionally distributed in a nano calcium phosphate / polymer substrate; the aperture is between 1 and 50 micrometers, and the porosity is between 30 and 80 percent; and hole walls can be partially communicated with each other. The preparation method comprises that: the nano calcium phosphate, a solvent and polymer organic phases are driven to form multiphase metastable state colloid by the action of a surfactant; the metastable state colloid is destabilized after freezing and subjected to water-phase separation; separated water is condensed into ice which is then taken as a template; water phase is induced to be solidified in certain direction by controlling the direction and the velocity of the freezing process; and the ice is sublimed by vacuum drying, and the directional porous structure is formed in the calcium phosphate / polymer composite material. The material has good biological structural hole characteristics, and can be taken as an engineering material of a tissue structure and a medical vector material for treating bone infection.

Description

technical field [0001] A nanometer calcium phosphate / polymer oriented pore composite material and its preparation method relate to an antibiotic drug carrier material and its preparation method, and belong to the technical field of oriented pore composite porous materials. Background technique [0002] At present, the preparation methods of inorganic / polymer porous materials mainly include 1) particle pore-forming method. The material and porogen particles are fully mixed, and then the porogen particles are removed by using the different solubility or volatility of the two to obtain Porous materials, such as solvent casting / particle rate leaching technology (Chinese patent CN1316464); 2) gas foaming method, using gas as a porogen, pressing the material into sheets by molding in a heated mold, and placing it in high-pressure CO 2 3) Particle sintering method, the particles used for pore formation are first sintered into a porous template, and then the template is repeatedly ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/56A61L27/58A61L27/12A61L27/18
Inventor 徐子颉汪飞马超王玮衍逯爱慧
Owner TONGJI UNIV
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