Degradable biomedical material Zn-Si-X zinc alloy and preparation method

A biomedical material, zn-si-x technology, applied in electrolytic coating, metal material coating technology, medical science, etc., can solve the problem of loss of mechanical integrity, fast corrosion of magnesium alloy, and incomplete function of implants Play and other issues to achieve the effect of good histocompatibility and blood compatibility

Pending Publication Date: 2021-07-13
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] The technical problem solved by the present invention is that most of the current degradable alloys are magnesium alloys, and the corrosion rate of magnesium alloys is too fast. Before the tissues and organs are fully healed, the implant will soon lose its mechanical integrity, making The role of the implant in the tissues and organs has not been fully exerted, and the healing degree and function of the tissues and organs are not complete

Method used

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  • Degradable biomedical material Zn-Si-X zinc alloy and preparation method

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preparation example Construction

[0056] A method of preparing a degradable biomedical material Zn-Si-X-cyclic alloy, the preparation method comprising the steps of:

[0057] Select the elemental composition and element content of the Zn-Si-X-Z-Z-zinc alloy of the biomedical material, and the corresponding feedstock is weighed and mixed according to the selected element composition and the element content, and mixed to obtain a mixture, in CO 2 SF 6 Under the protective atmosphere, the aforementioned mixture is smelted or sintered, and the degradable biomedical material Zn-Si-X-Z Zinc alloy is obtained by obtaining a porous structure after cooling.

[0058] In particular, the preparation method comprises the steps of:

[0059] Select the elemental composition and element content of the Zn-Si-X-Z-Z-zinc alloy of the biomedical material, and the corresponding feedstock is weighed and mixed according to the selected element composition and the element content, and mixed to obtain a mixture, in CO 2 SF 6 Under the pro...

Embodiment 1

[0086] A method of preparing a degradable biomedical material Zn-Si-X-Z-Z-Z zinc alloy, the specific steps are as follows;

[0087] Pure Zn (99.99wt.%), Pure Si (99.95wt.%), Pure X (X is Ga, Ge, Cu, Ag, Mn, Mg, Ca, Sr, Fe, Ti, Zr, Sn, Y, Nd At least one element in YB) (purchased from Beijing Cuiberin Nonferrous Metallic Metal Technology Development Center) as a raw material, mixed according to different quality, in CO 2 + Sf 6 Under the protective atmosphere, smelting at 600 ° C, after the raw material is sufficiently melted, after holding 10 min, the circulating water is rapidly cooled to prepare Zn-Si-X-Zinc alloy ingot.

Embodiment 2

[0089] A method of preparing a degradable biomedical material Zn-Si-X-Z-Z-Z zinc alloy, the specific steps are as follows;

[0090] First Step in Example 1 was prepared according to the zinc Zn-Si-X based alloy ingot; and the above-described Zn-Si-X to obtain a zinc-based alloy hot-rolled ingot, ingot preheated to 250 deg.] C, and then hot The rolling mode is repeated rolled in a round-trolling mill, and the temperature rolled temperature is 250 ° C, and finally in the finishing mill, it rolled to 1.5 mm thickness at 250 ° C ( figure 1 ).

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Abstract

The embodiment of the invention discloses a degradable biomedical material Zn-Si-X zinc alloy and a preparation method, and belongs to the technical field of medical degradable alloys. The Zn-Si-X zinc alloy comprises the main elements of Zn, Si and X, X is at least one of Ga, Ge, Cu, Ag, Mn, Mg, Ca, Sr, Fe, Ti, Zr, Sn, Y, Nd and Yb, Si, in percentage by weight, is larger than 0 and smaller than or equal to 20 wt%, and X, in percentage by weight, is larger than or equal to 0 and smaller than or equal to 15 wt%. The preparation method comprises the following steps of mixing Zn, Si and X elements, smelting or sintering or applying a coating after smelting or sintering to obtain the Zn-Si-X alloy. According to the alloy and the method, the mechanical property of the prepared zinc alloy meets strength and toughness requirements of medical implants, meanwhile, the zinc alloy can be degraded in vivo, and the zinc alloy has a biological corrosion degradation characteristic and an appropriate corrosion rate so as to provide long-term and effective mechanical support dual characteristics.

Description

Technical field [0001] The present invention belongs to the technical field of medical degradable alloy, and is relate to a degradable biomedical material Zn-Si-X-cyclic alloy and preparation method. Background technique [0002] With the development of medical and materials, for materials that require temporary service, such as suture, fracture fixing plates, cardioe cervicinal brackets, urethra brackets, biliary brackets, etc., people want to implant the materials only to temporarily replace The role and gradually degrades absorption as the regeneration of organizers or organs, to minimize the long-term effects of materials on the body. Because biodegradable materials are prone to gradually degradation of media in biology and body fluids, their decomposition products can be metabolized, and they finally discharge their body, no need for secondary surgery, will not give patients with secondary surgery and heart Pain, thus increasingly attaches people's attention, has become the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C18/00B22D11/06B22F3/20C22C1/02C22C1/08C23C4/10C23C4/134C23C26/00C25D11/34C25D13/02A61L27/02A61L27/04A61L27/06A61L27/54A61L27/58A61L31/02A61L31/14A61L31/16
CPCA61L27/02A61L27/042A61L27/047A61L27/06A61L27/54A61L27/58A61L31/02A61L31/022A61L31/148A61L31/16A61L2430/02A61L2430/22B22D11/0611B22F3/20C22C1/02C22C1/08C22C18/00C23C4/10C23C26/00C25D11/34C25D13/02C23C4/134
Inventor 李华芳王鹏宇黄金燕林桂彩郑宜星
Owner UNIV OF SCI & TECH BEIJING
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