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Patch and patch preparation

A patch and preparation technology, applied in the field of patch preparations, can solve the problem of insufficient self-retention performance as a patch material, and achieve the effect of excellent operability and easy maintenance

Inactive Publication Date: 2009-07-22
NITTO DENKO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, it is conceivable that such a patch material is still insufficient in self-holding performance as a patch material depending on the liner adopted, and this leaves room for improving the workability of the patch material

Method used

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  • Patch and patch preparation
  • Patch and patch preparation
  • Patch and patch preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] The grooves of the liner itself form:

[0095] Various polyethylene terephthalate films (PET) having bending resistance and thickness shown in Table 1 were used as liners. By using the laser marking machine ML9110 (manufactured by Keyence, CO. 2 Laser, power consumption: 450VA) laser cutting device (manufactured by DaishoKagaku Kikai Kogyo K.K.) and simultaneously regulate the laser output and feed rate, form grooves on the pad, and then cut the pad into a square of 32mm×32mm to Samples 1 to 7 having various groove shapes shown in Table 1 were prepared.

Embodiment 2

[0097] Prepare patch formulations with grooved liners:

[0098] 1. Preparation of Pressure Sensitive Adhesives

[0099] 30 parts of low molecular weight polyisobutene (viscosity average molecular weight: 60,000, HIMOL6H, manufactured by Nippon Petrochemicals Co., Ltd.) and 20 parts of high molecular weight polyisobutylene (viscosity average molecular weight: 990,000, VISTANEX MML-80, manufactured by Exxon Chemical) were dissolved in ethyl alcohol in alkane to prepare a polyisobutylene-based pressure-sensitive adhesive solution (solid content concentration: 30% by weight). 6 parts of polybutene (viscosity average molecular weight: 1,260, HV-300F, manufactured by Nippon Petrochemicals Co., Ltd.) and 14 parts of alicyclic petroleum resin (softening point: 100° C., ARKON P-100, manufactured by Arakawa Chemical Industries Co., Ltd.) were added into the solution and dissolve with stirring. A hexane solution of tulobuterol (TBL) was added to the resulting solution to have a content...

Embodiment 3

[0113] Storage test:

[0114] The packaged patch formulations were stored at 40°C and 75% relative humidity for one, two, three or six months.

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Abstract

The invention relates to a patch comprising a support, a pressure-sensitive adhesive layer formed on one face of the support and a liner having a thickness of T which is laminated on the pressure-sensitive adhesive layer, characterized in that the liner has a groove having a depth of T / 2 or more but less than T measured from the surface in the opposite side to the lamination face of the pressure-sensitive adhesive layer, the groove has such a planar shape that the liner is divided into two or more sections by the groove, and the bending resistance of the liner before forming the groove is 50 mm or more.

Description

technical field [0001] The present invention relates to a patch comprising a backing, a pressure-sensitive adhesive layer formed on one surface of the backing, and a patch preparation laminated on the pressure-sensitive adhesive layer, and a patch preparation containing a drug in a pressure-sensitive adhesive layer. Liner on pressure sensitive adhesive layer. Background technique [0002] In recent years, various patches and patch preparations have been developed. These patches and patch formulations are excellent in view of wound protection and continuous transdermal delivery of drugs. In a patch or patch formulation, a pressure-sensitive adhesive layer is laminated on a backing formed of fabric or plastic film, and a liner is laminated on the pressure-sensitive adhesive layer. This liner not only protects the exposed surface of the pressure-sensitive adhesive layer, but when it is used in a patch or patch preparation using a flexible backing, it exerts the effect of impr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F13/02A61K9/70
CPCA61F2013/00651A61K9/703A61K9/7053A61F13/02A61K9/70
Inventor 播摩润樱庭怜平
Owner NITTO DENKO CORP
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