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External plaster for treating liver disease and preparation method thereof

A patch, a technology for chronic liver disease, applied in the field of traditional Chinese medicine preparations, can solve problems such as increasing the burden on the liver, and achieve good hepatosplenomegaly, definite curative effect, and moderate adhesion

Active Publication Date: 2012-05-30
NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the clinical treatment of this disease is mostly oral medicine, which also increases the burden on the liver while treating liver disease, and there is a lack of drugs with better therapeutic effects. Therefore, it is particularly important to develop new Chinese medicines that relieve pain and improve the quality of life of patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] The preparation of the extract in the liver disease patch of embodiment 1

[0100] Prescription: Astragalus 960g, Turmeric 960g, Curcuma 640g

[0101] Wang Buliuxing 640g Myrrh 640g Prunella vulgaris 960g

[0102] Preparation:

[0103] Mix turmeric, curcuma, and myrrh, powder it through a 20-mesh sieve, and extract it through supercritical CO2. The extraction temperature is 47°C, the pressure is 22.0mpa, CO 2 The flow rate is 110L / hr, collect the extract; the residue is mixed with Astragalus membranaceus, Prunella vulgaris, and Buliuxing medicinal materials, reflux with 7 times the amount of 70% ethanol for 2 hours, filter, and collect the filtrate; add 4 times the amount of 70% ethanol to the residue Reflux for 2 hours, filter, and collect the filtrate; add 3 times the amount of 70% ethanol to the residue, reflux for 1 hour, filter, and collect the filtrate. The three filtrates were combined and concentrated under reduced pressure to a liquid extract with a re...

Embodiment 2

[0104] The preparation of the extract in the liver disease patch of embodiment 2

[0105] Prescription: Astragalus 800g, Curcuma 40g, Curcuma 40g

[0106] Wangbuliuxing 40g Myrrh 40g Prunella vulgaris 40g

[0107] Preparation:

[0108] Mix turmeric, curcuma, and myrrh, powder it through a 20-mesh sieve, and pass through a CO 2 Supercritical extraction, extraction temperature 35°C, pressure 8.0mpa, CO 2 The flow rate is 40L / hr, collect the extract; the residue is mixed with Astragalus membranaceus, Prunella vulgaris, and Buliuxing medicinal materials, reflux with 4 times the amount of 40% ethanol for 1 hour, filter, and collect the filtrate; add 3 times the amount of 40% ethanol to the residue Reflux for 1 hour, filter, and collect the filtrate; add 4 times the amount of 40% ethanol to the residue, reflux for 0.5 hour, filter, and collect the filtrate. The three filtrates were combined and concentrated under reduced pressure to a liquid extract with a relative density...

Embodiment 3

[0109] The preparation of the extract in the liver disease patch of embodiment 3

[0110] Prescription: Astragalus 40g, Turmeric 800g, Curcuma 40g

[0111] Wangbuliuxing 40g Myrrh 40g Prunella vulgaris 40g

[0112] Preparation:

[0113] Mix turmeric, curcuma, and myrrh, powder it through a 20-mesh sieve, and pass through a CO 2 Supercritical extraction, extraction temperature 40°C, pressure 10.0mpa, CO 2 The flow rate is 60L / hr, collect the extract; the residue is mixed with Astragalus membranaceus, Prunella vulgaris, and Wangbuliuxing medicinal materials, reflux with 5 times the amount of 50% ethanol for 1.5 hours, filter, and collect the filtrate; add 3.5 times the amount of 50% ethanol to the residue Reflux for 1.5 hours, filter, and collect the filtrate; add 3.5 times the amount of 50% ethanol to the residue, reflux for 0.8 hours, filter, and collect the filtrate. The three filtrates were combined and concentrated under reduced pressure to a liquid extract with a...

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Abstract

The invention discloses an external-use plaster (liver-disease plaster) for treating liver diseases. The traditional Chinese medicine external-use plaster is prepared from medicinal extracts of radix curcumae, zedoary, myrrh, hoantchy roots, prunella vulgaris, cowherb seeds and medical subsidiary substances, wherein the medical subsidiary substances comprise styrene-isoprene-styrene copolymer (SIS), tackifier, plasticizer, filler, permeation promoting agents and the like. The invention also discloses a method for preparing the liver-disease plaster. The method adopts supercritical extraction combined with alcohol extraction, and comprises the steps of using SIS hot melt adhesive and other subsidiary substances to prepare a matrix and spreading mixed medicine so as to form a resin-type external-use plaster. As the method adopts the novel medicine subsidiary substances and a novel preparation formulation technique, the plaster has the advantages of good skin adhesion, adhesive force, pharmaceutical transdermal absorptivity and good effects of easing lateral thorax pain and hepatosplenomegaly to patients suffering from liver-depression blood-stasis type liver diseases, is convenient to use, can be repeatedly pasted, and can meet the demand of modern medical treatment better.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to an external patch (liver disease patch) for treating liver diseases; in addition, the invention also relates to a preparation method of the external patch. Background technique [0002] Liver disease is a common disease and a frequently-occurring disease in my country. In my country, there are about hundreds of millions of people infected with hepatitis virus, and about 30 million patients with chronic hepatitis, which seriously affect people's health. [0003] Hypochondriac pain and hepatosplenomegaly are two very common clinical symptoms in patients with liver disease. At present, the clinical treatment of this disease is mostly oral medicine, which also increases the burden on the liver while treating liver disease, and there is a lack of drugs with better therapeutic effects. Therefore, it is particularly important to develop new Chinese medicines that relieve pai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/70A61K47/02A61K47/22A61K47/32A61K47/34A61K47/44A61P1/16A61K47/26
Inventor 刘志远阮克锋张继全汤秀珍唐英
Owner NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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