Aerosol of percutaneous medicament

A technology for aerosols and medicines, applied in the field of aerosols, can solve problems such as insufficient liquid flow, and achieve the effects of good use feeling, inhibition of liquid flow, and excellent efficacy.

Inactive Publication Date: 2009-08-05
KOWA CO LTD +1
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, all of these are not sufficient for suppressing liquid shedding in the application site

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Aerosol of percutaneous medicament
  • Aerosol of percutaneous medicament
  • Aerosol of percutaneous medicament

Examples

Experimental program
Comparison scheme
Effect test

manufacture example 1

[0075] Production Example 1 The stock solution was produced by the following method

[0076] (1) Add 0.5 g of hydroxypropylmethylcellulose 2906 (Metolose 65SH-1500: Shin-Etsu Chemical Industry) and 0.1 g of hydroxypropylcellulose (HPC-SSL: Nippon Soda) to 30 g of water at 80°C to make Cool and swell after dispersion to obtain an aqueous phase.

[0077] (2) Mix 6 g of propylene glycol, 7 g of polyethylene glycol, 1.8 g of benzyl alcohol, 4 g of diisopropyl adipate, and 36 g of isopropanol to obtain a uniform solution. Next, 3 g of 1-menthol and 1 g of indomethacin were dissolved in the obtained homogeneous solution to obtain a main drug phase.

[0078] (3) Mix and stir the aqueous phase obtained in (1) and the main drug phase obtained in (2), add the aqueous solution obtained by dissolving 0.01g sodium edetate in 5g water to the obtained liquid, and then add An appropriate amount of 1.2% by mass of diisopropanolamine aqueous solution was stirred well to prepare 100 g of a sto...

Embodiment 1

[0080] 65 parts by mass of the undiluted solution obtained in Production Example 1 and 35 parts by mass of dimethicone were airtightly filled in a device (nozzle in the device: F-96 (manufactured by Maruichi Co., Ltd.)) that exhibits a spray pattern that expands flat in one direction. Ether, obtains the aerosol of embodiment 1. In addition, when the spray particle diameter of the aerosol of Example 1 was measured with a laser diffraction particle size distribution analyzer (SPRAYTEC: manufactured by Malvern Co., Ltd.), it was 110 μm.

manufacture example 2

[0104] (1) Add 0.5 g of methyl cellulose (Metolose SM-4000: Shin-Etsu Chemical Industry) and 0.1 g of hydroxypropyl cellulose (HPC-SSL: Nippon Soda) to 30 g of water at 80°C, disperse and cool Swells to give an aqueous phase.

[0105] (2) Mix 6 g of propylene glycol, 7 g of polyethylene glycol, 1.8 g of benzyl alcohol, 4 g of diisopropyl adipate, and 36 g of isopropanol to obtain a uniform solution. Next, 5 g of 1-menthol, 2 g of methyl salicylate, 1 g of ethylene glycol salicylate, 2 g of dl-camphor, 0.5 g of eucalyptus oil, and 0.1 g of glycyrrhizic acid were dissolved in the obtained homogeneous solution to obtain a main drug phase.

[0106] (3) Mix and stir the aqueous phase obtained in (1) and the main drug phase obtained in (2), add the aqueous solution obtained by dissolving 0.01g sodium edetate in 5g water to the obtained liquid, and then add An appropriate amount of 1.2% by mass of diisopropanolamine aqueous solution was stirred well to prepare 100 g of a stock solut...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides an aerosol containing penetration drug preventing fluid flowing down at a use location. The aerosol comprises a device representing an injection figure expanding in a direction during injection, and stock solution enclosed into a container of the device and containing at least one penetration drug.

Description

technical field [0001] The present invention relates to an aerosol formulation for percutaneous absorption of medicines. More specifically, it relates to an aerosol of a transdermally absorbed drug that suppresses liquid run-off at an application site. Background technique [0002] The aerosol technology that sprays the contents of a pressure-resistant container into mist or bubbles by gas pressure is used in various fields such as the paint field and the pharmaceutical field. [0003] Usually, this aerosol-related device (aerosol can) has a valve structure that is opened by pressing down a handle, and a button (actuator: regulator) installed at the front end of the handle. It is supported that the square can move up and down in the state of adding potential energy. In this way, when in use, the valve structure is opened by pressing the button downward, so that the content in the container is sprayed from the spout through the depressed handle. [0004] Aerosol has many a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/12A61P29/00A61M37/00
CPCA61K9/0014A61K9/124
Inventor 杉山育美金箱真堀池至
Owner KOWA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap