Valveless micro-flow control gradient real-time reaction chip and reaction control method

A technology of reaction chip and control method, which is applied in chemical method analysis, instruments, analysis materials, etc., can solve the problems of increasing the difficulty of control and increasing the difficulty of processing, and achieves the effect of easy operation and cost reduction.

Inactive Publication Date: 2009-08-05
SHANGHAI JIAO TONG UNIV
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Problems solved by technology

Although Hsin-Chih Yeh's design can effectively combine the formation of gradient field and its reaction with target molecules, this type of chip uses external valves to control or fix the reactive biomolecules in

Method used

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  • Valveless micro-flow control gradient real-time reaction chip and reaction control method
  • Valveless micro-flow control gradient real-time reaction chip and reaction control method
  • Valveless micro-flow control gradient real-time reaction chip and reaction control method

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Embodiment Construction

[0027]The embodiments of the present invention are described in detail below in conjunction with the accompanying drawings: this embodiment is implemented on the premise of the technical solution of the present invention, and detailed implementation methods and specific operating procedures are provided, but the protection scope of the present invention is not limited to the following the described embodiment.

[0028] Such as Figure 1-2 As shown, the valveless microfluidic gradient reaction chip involved in this embodiment is basically characterized by an improved design on the traditional pyramidal microfluidic gradient chip, and in the pipeline of the concentration gradient field formation area at the end of the outlet, an increase of Soft magnetic micropillar array2. In this embodiment, 8 linear drug concentration gradients can be formed at the end through the injection of the injection ports 4 and 5, and the reaction between the drug and the target molecule can be carri...

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Abstract

The invention relates to a valveless micro-fluidic gradient real-time reaction chip and a reaction control method in the micro-fluidic technical field. Magnetic particles are marked on target molecules which need reacting with drugs, while non-retentive micro-column arrays are arranged in a concentration gradient field forming zone in the front of the tail end of an outlet of a traditional pyramid-type micro-fluidic gradient chip, by the structure, a high gradient magnetic field generated under an external magnetic field previously adsorbs drug molecules marked with the magnetic particles before the gradient field reaction, thereby the drug molecules are fixed in a pipeline at the front end of the outlet of the pyramid-type micro-fluidic gradient chip. When in gradient real-time reaction, after being continuously shunted and mixed and finally forming the gradient field at the tail end of the chip and flowing through the soft non-retentive micro-column arrays, drugs can simultaneously react with the drug molecules fixed hereof. The design of the chip is mainly used in various aspects such as the research of biological macromolecule reaction and action mechanism, the screen of drugs, and the like.

Description

technical field [0001] The invention relates to a chip and a control method in the field of microfluidic technology, in particular to a valveless microfluidic gradient real-time reaction chip and a reaction control method. Background technique [0002] With the continuous development of biomedicine and chemistry, many studies are currently focused on the molecular level. In recent years, the emergence of microfluidic technology has led to a new direction in biochemical analysis. Microfluidic technology refers to the technology of manipulating and analyzing fluids in micron-scale (mainly width and height) pipes. Compared with conventional methods, microfluidic technology can effectively reduce reagent consumption, shorten reaction time, make automation higher, achieve high-throughput, large-scale detection, thereby reducing costs and more reliable detection results. Therefore, it has been widely used in disease detection, environmental monitoring, chemical synthesis, gene s...

Claims

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Application Information

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IPC IPC(8): G01N31/00G01N33/543B81B7/04
Inventor 陈翔肖丽君汪鹏朱军陈迪
Owner SHANGHAI JIAO TONG UNIV
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