Application of Xuebijing in preparing medicament for treating paraquat poisoning

Abstract

The invention discloses an application of Xuebijing in preparing medicament for treating paraquat poisoning, which is used for treating pulmonary fibrosis caused by paraquat poisoning. Xuebijing injection is used for carrying out early interference therapy on paraquat poisoned patients so that the TGF-beta 1 and 111 type PIIIP level in the blood serum of the paraquat poisoned patients can be obviously lowered, thus restraining the occurrence and development of pulmonary fibrosis caused by paraquat poisoning. Interference therapy of use of Xuebijing injection on the paraquat poisoned patients can obviously improve the respiratory function of the patients, relieve the physiological damage of the lung tissue after paraquat poisoning, reduce the occurrence rate of pulmonary fibrosis, lessen the pulmonary fibrosis degree and lower the fatality rate of the paraquat poisoned patients, thus improving the prognosis of the patients.

Description

technical field [0001] The invention discloses the application of Xuebijing in the preparation of medicines for treating paraquat poisoning, and belongs to the technical field of traditional Chinese medicine pharmacy. Background technique [0002] Paraquat (paraquat, PQ), also known as Gramoxone, Paraquat, chemical name (1,1'-dimethyl-4,4'-bipyridiumdichloride) is called 1,1'-dimethyl-4,4' -Dichlorodipyridine is an organic heterocyclic broad-spectrum non-selective contact herbicide and defoliant. PQ is highly toxic to humans and animals, and the lethal dose for humans is about 1 to 3 g. PQ poisoning has become a serious internal medicine emergency that seriously affects the health of the people in our country, and its degree of harm greatly exceeds that of tetramine and organophosphorus pesticide poisoning. Due to the lack of specific antidotes and chelating agents that can bind to PQ in blood or tissues, the fatality rate of PQ poisoning is as high as 60% to 87.8%. Oral ...

AI Technical Summary

Problems solved by technology

Although the current advanced life support measures can reduce the proportion of PQ poisoning patients dying of MODS, they still cannot block the occurrence of pulmonary fibrosis after PQ poisoning and reduce the proportion of PQ poisoning patients dying of delayed pulmonary fibrosis

[0003] At present, although the use of advanced life support measures can reduce the proportion of patients with PQ poisoning who died of MODS, it still cannot block the occurrence of pulmonary fibrosis after PQ poisoning and reduce the proportion of patients with PQ poisoning who died of delayed pulmonary fibrosis

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