Amphiphilic superparamagnetism magnetic resonance contrast medium and preparation method thereof

A magnetic resonance contrast agent and superparamagnetic technology, which is applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agent, etc., can solve the problems of low coefficient and cannot be suitable for advanced magnetic resonance imaging, etc., and achieves good dispersion, scientific research and compatibility. The effect of convenient clinical application and good biocompatibility

Inactive Publication Date: 2009-09-02
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies have shown that the magnetic moment and R of ferric ferrite nanomaterials 2 Coefficients are very low, not suitable for advanced MRI applications

Method used

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  • Amphiphilic superparamagnetism magnetic resonance contrast medium and preparation method thereof
  • Amphiphilic superparamagnetism magnetic resonance contrast medium and preparation method thereof
  • Amphiphilic superparamagnetism magnetic resonance contrast medium and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] The preparation method of the amphiphilic superparamagnetic magnetic resonance contrast agent provided in this embodiment, the specific operation is as follows:

[0034] Add 2mmol of iron triacetylacetonate and 1mmol of manganese acetylacetonate into 30ml of tetraethylene glycol; perform anhydrous and oxygen-free operation, heat the reaction system under the protection of an inert gas, and when the temperature rises to 120°C, keep the reaction for 2 hours; then continue Heat up, when the temperature rises to 210°C, keep warm for 2 hours; then continue to heat up, when the temperature rises to 295°C, keep warm for 2 hours; the reaction is completed, naturally cool to room temperature, centrifuge, wash the precipitate with absolute ethanol , dried under vacuum at 25°C for 15 hours to obtain black MnFe coated with tetraethylene glycol molecules. 2 o 4 Nanoparticles.

[0035] Weigh the surface of the above-made MnFe coated with polyol molecules 2 o 4 15 mg of nanopartic...

Embodiment 2

[0047] The preparation method of the amphiphilic superparamagnetic magnetic resonance contrast agent provided in this embodiment, the specific operation is as follows:

[0048] Add 2mmol of iron triacetylacetonate and 1mmol of manganese acetylacetonate into 10ml of tetraethylene glycol; perform anhydrous and oxygen-free operation, heat the reaction system under the protection of an inert gas, and when the temperature rises to 100°C, keep the reaction for 3 hours; then continue Heat up, when the temperature rises to 200°C, keep warm for 3 hours; then continue to heat up, when the temperature rises to 285°C, keep warm for 3 hours; the reaction is completed, naturally cool to room temperature, centrifuge, wash the precipitate with absolute ethanol , dried under vacuum at 25°C for 15 hours to obtain black MnFe coated with tetraethylene glycol molecules. 2 o 4 Nanoparticles.

[0049] Weigh the surface of the above-made MnFe coated with polyol molecules 2 o 4 15 mg of nanopartic...

Embodiment 3

[0052] The preparation method of the amphiphilic superparamagnetic magnetic resonance contrast agent provided in this embodiment, the specific operation is as follows:

[0053] Add 2mmol of iron triacetylacetonate and 1mmol of manganese acetylacetonate into 50ml of tetraethylene glycol; perform anhydrous and oxygen-free operation, heat the reaction system under the protection of an inert gas, and when the temperature rises to 140°C, keep the reaction for 1 hour; then continue Heat up, when the temperature rises to 220°C, keep warm for 1 hour; then continue to heat up, when the temperature rises to 305°C, keep warm for 1 hour; the reaction is completed, naturally cool to room temperature, centrifuge, wash the precipitate with absolute ethanol , dried under vacuum at 25°C for 15 hours to obtain black MnFe coated with tetraethylene glycol molecules. 2 o 4 Nanoparticles.

[0054] Weigh the surface of the above-made MnFe coated with polyol molecules 2 o 4 15 mg of nanoparticles a...

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Abstract

The invention discloses an amphiphilic superparamagnetism magnetic resonance contrast medium and a preparation method thereof. The contrast medium takes MnFe2O4 nanometer grains as cores; polyalcohol molecules evenly clad the surfaces of the MnFe2O4 nanometer grains; and part of hydroxies on the outer ends of the polyalcohol molecules react with 9-fluorenylmethyl chloroformate to form amphiphilic shell structures through acyl chloride reactions. The preparation method comprises the following steps: taking the polyalcohol as a solvent, pyrolyzing ferric and manganese acetylacetonates at a high temperature to obtain the MnFe2O4 nanometer grains clad by the polyalcohol molecules through, and then carrying out the acyl chloride reaction between 9-fluorenylmethyl chloroformate and polyalcohol hydroxies on the surfaces of the nanometer grains. The contrast medium has the advantages of small grain size, high crystallinity, high saturation magnetization rate, high relaxation capability, good biological compatibility, low toxicity and good stability. The preparation method has the advantages of simple operation, low cost, low requirements on the equipment, and easy realization of industrialized production.

Description

technical field [0001] The invention relates to a superparamagnetic magnetic resonance contrast agent and a preparation method thereof, in particular to a MnFe 2 o 4 The invention discloses a superparamagnetic magnetic resonance contrast agent with a hydrophilic and lipophilic amphiphilic shell structure and a preparation method with simple process, low manufacturing cost and industrial implementation. Background technique [0002] Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) is the most important advanced medical imaging technology developed after the 1980s. It has outstanding advantages such as high resolution, multiple imaging parameters, and safe use. has great application potential. MRI contrast agent is an imaging-enhanced contrast agent used to shorten imaging time and improve imaging contrast and clarity. It can change the relaxation rate of water protons in local tissues and improve the imaging contrast between normal and diseased parts to display ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/06
Inventor 杨仕平张翠侠杨红田启威
Owner SHANGHAI NORMAL UNIVERSITY
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