Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation and application of pharmaceutical composition containing collagen and isosorbide mononitrate

A technology of isosorbide dinitrate and collagen, which is applied in the field of medicine and can solve problems such as subacute toxicity and long-term toxicity

Inactive Publication Date: 2009-09-09
白大成 +2
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] 2. Long-term toxicity / subacute toxicity
[0018] The current indications of various dosage forms of isosorbide mononitrate are cardiovascular diseases. The application of collagen and isosorbide mononitrate pharmaceutical composition in domestic and foreign impotence or low libido indications has not been reported or related patents. Has a broad market prospect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation and application of pharmaceutical composition containing collagen and isosorbide mononitrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: Liniment formula unit g

[0023] Collagen 10

[0024] Isosorbide mononitrate 0.025

[0025] Glycerin 50

[0026] Laurazozone 10

[0027] Ethanol 100

[0028] Deionized water 830

[0029] The liniment of the present invention is obtained by adjusting the pH value to 5.5 with reagents such as lactic acid, which is prepared according to known techniques, put into a bottle, and sealed.

Embodiment 2

[0030] Embodiment 2: Gel formula: unit g

[0031] Collagen 10

[0032] Isosorbide mononitrate 0.025

[0033] Glycerin 50

[0034] Laurazozone 10

[0035] Carbomer 10

[0036] Deionized water 920

[0037] Preparation method:

[0038] 1. Take carbomer, add 10 grams to 500ml water to swell naturally for 24 hours, stir well and set aside.

[0039] 2. 10g of collagen, 0.025g of isosorbide mononitrate, 50g of glycerin, and 100g of laurozozone for later use.

[0040] 3. Add the obtained above-mentioned solution to the carbomer solution to be used, and stir well to make it into a gel. Add deionized water to the gel to make the total weight of the gel 1000g, adjust the pH value to 5.5 with lactic acid and other reagents to obtain the gel preparation of the present invention, prepare it according to known techniques, put it into a container, and seal it .

Embodiment 3

[0041] Embodiment 3: Ointment formula: unit g

[0042] Isosorbide mononitrate 10

[0043] Stearic acid 60

[0044] Stearyl Alcohol 60

[0045] Vaseline 60

[0046] Liquid paraffin 84

[0047] Polyethylene glycol 40

[0048] Tween-80 44

[0049] Glycerin 300

[0050] Deionized water 342

[0051] Preparation method:

[0052] 1. Mix the oil phase substances, namely 60g of stearic acid, 60g of stearyl alcohol, 60g of petrolatum, and 84g of liquid paraffin, and heat to 40-80°C to dissolve.

[0053] 2. Mix the water phase substances, namely 300g of glycerin, 40g of polyethylene glycol, 44g of Tween-804g, and 342g of water, and heat to 40-80~C.

[0054] 3. Mix the oil and water two-phase substances at 80°C, cool to room temperature, add 10 g of isosorbide mononitrate, and mix well to obtain an ointment.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention discloses a pharmaceutical composition for treating impotence and frigidity. Penis cavernous tissue of an impotence patient has obvious pathological changes, and the pathological damages are possibly related to ischemia and hypoxia in local tissues and lack of collagen. Therefore, local application of small molecular collagen absorbed through skin is helpful for improving the toughness of penile tissues as well as the elasticity and the tensility of the tissues; the main pharmacological actions of isosorbide mononitrate include relaxing smooth muscles and expanding peripheral blood vessels, and local application can ensure cavernous hyperaemia and penile erection; combined local application of collagen and isosorbide mononitrate only requires small doses and almost has no side effects of oral drugs; isosorbide mononitrate does not arouse sexual desire and just assists a patient in restoring normal erection function when sexual excitement appears; moreover, the drug composition also has remarkable curative effects of improving female frigidity, thereby providing a novel choice for treating the impotence and the frigidity.

Description

[technical field] [0001] The invention relates to the technical field of medicine, and relates to a pharmaceutical composition for treating impotence and low libido. [Background technique] [0002] Impotence is the most common and serious symptom of male sexual dysfunction, and its pathogenesis is still unclear. According to the cause of impotence, it can be divided into psychological and organic. According to foreign literature reports, impotence patients account for 37-42% of male sexual dysfunction, and domestic sample surveys show that 10-20% of adult males have impotence. Impotence is an important factor affecting people's physical and mental health, family harmony and social stability. The traditional concept believes that impotence is mainly caused by psychological and spiritual factors, so clinical treatment focuses on psychological treatment, while some patients with organic impotence who need surgery or drug treatment do not pay attention. [0003] Overseas stud...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/39A61K31/34A61K47/34A61K9/06A61K9/46A61K9/02A61K9/00A61P15/10A61K47/10A61K47/22A61K47/26A61K47/32
Inventor 白大成郝斌肖柏青
Owner 白大成
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products