Preparation and application of pharmaceutical composition containing collagen and isosorbide mononitrate
A technology of isosorbide dinitrate and collagen, which is applied in the field of medicine and can solve problems such as subacute toxicity and long-term toxicity
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Embodiment 1
[0022] Embodiment 1: Liniment formula unit g
[0023] Collagen 10
[0024] Isosorbide mononitrate 0.025
[0025] Glycerin 50
[0026] Laurazozone 10
[0027] Ethanol 100
[0028] Deionized water 830
[0029] The liniment of the present invention is obtained by adjusting the pH value to 5.5 with reagents such as lactic acid, which is prepared according to known techniques, put into a bottle, and sealed.
Embodiment 2
[0030] Embodiment 2: Gel formula: unit g
[0031] Collagen 10
[0032] Isosorbide mononitrate 0.025
[0033] Glycerin 50
[0034] Laurazozone 10
[0035] Carbomer 10
[0036] Deionized water 920
[0037] Preparation method:
[0038] 1. Take carbomer, add 10 grams to 500ml water to swell naturally for 24 hours, stir well and set aside.
[0039] 2. 10g of collagen, 0.025g of isosorbide mononitrate, 50g of glycerin, and 100g of laurozozone for later use.
[0040] 3. Add the obtained above-mentioned solution to the carbomer solution to be used, and stir well to make it into a gel. Add deionized water to the gel to make the total weight of the gel 1000g, adjust the pH value to 5.5 with lactic acid and other reagents to obtain the gel preparation of the present invention, prepare it according to known techniques, put it into a container, and seal it .
Embodiment 3
[0041] Embodiment 3: Ointment formula: unit g
[0042] Isosorbide mononitrate 10
[0043] Stearic acid 60
[0044] Stearyl Alcohol 60
[0045] Vaseline 60
[0046] Liquid paraffin 84
[0047] Polyethylene glycol 40
[0048] Tween-80 44
[0049] Glycerin 300
[0050] Deionized water 342
[0051] Preparation method:
[0052] 1. Mix the oil phase substances, namely 60g of stearic acid, 60g of stearyl alcohol, 60g of petrolatum, and 84g of liquid paraffin, and heat to 40-80°C to dissolve.
[0053] 2. Mix the water phase substances, namely 300g of glycerin, 40g of polyethylene glycol, 44g of Tween-804g, and 342g of water, and heat to 40-80~C.
[0054] 3. Mix the oil and water two-phase substances at 80°C, cool to room temperature, add 10 g of isosorbide mononitrate, and mix well to obtain an ointment.
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