Production technology separating glucosamine hydrochloride from citric acid sludge

A technology of glucosamine hydrochloride and citric acid residue, applied in amino sugar, sugar derivatives, sugar derivatives and other directions, can solve problems such as short hydrolysis time, achieve the effects of good repeatability, high yield and avoid pollution

Inactive Publication Date: 2009-10-07
技源生物制品(徐州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The hydrolysis time of this process is short, only 3 hours, while the hydrolysis time of the US patent needs 4-25 hours;

Method used

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  • Production technology separating glucosamine hydrochloride from citric acid sludge

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Experimental program
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Effect test

Embodiment 1

[0053] Dry 1000 g of citric acid residue and hydrolyze with 2500 ml of 31% hydrochloric acid at a temperature of 95° C. for 3 hours. Cool to below 70°C, filter, wash the filter residue with 500ml of pure water, combine the filtrate, and then transfer it to a D101 macroporous resin column with 200ml of resin in the adsorption column, control the flow rate at 200ml / hour during adsorption, and then wash the resin with 600ml of pure water Column, combined effluent and water washes. The decolorizing liquid is concentrated in vacuum, the vacuum degree is controlled at -0.80--0.99Mpa, the temperature is controlled below 80°C, concentrated until a large number of crystals appear, and cooled and settled for 24 hours. Filtrate the crude crystalline product, dissolve the crude crystalline product with 200ml of pure water, then pass through a 0.45μm microporous membrane, concentrate the microfiltrate in vacuum, control the vacuum at -0.80--0.99Mpa, control the temperature below 80°C, and ...

Embodiment 2

[0055] 1000 g of dried citric acid residue was hydrolyzed with 3000 ml of 25% hydrochloric acid at a temperature of 100° C. for 3.5 hours. Cool to below 70°C, filter, wash the filter residue with 500ml of pure water, combine the filtrate, and then transfer it to a D138 macroporous resin column. The adsorption column is filled with 200ml of resin, and the flow rate during adsorption is controlled at 200ml / hour, and then the resin is washed with 600ml of pure water Column, combined effluent and water washes. The decolorizing liquid is concentrated in vacuum, the vacuum degree is controlled at -0.80--0.99Mpa, the temperature is controlled below 80°C, concentrated until a large number of crystals appear, and cooled and settled for 24 hours. Filtrate the crude crystalline product, dissolve the crude crystalline product with 200ml of pure water, then pass through a 0.2μm microporous membrane, concentrate the microfiltrate in vacuum, control the vacuum at -0.80--0.99Mpa, control the ...

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Abstract

The invention belongs to a natural product extraction method, in particular to a production technology separating glucosamine hydrochloride from citric acid sludge, which has the following steps: the citric acid sludge is sequentially hydrolyzed by hydrochloric acid, filtered, absorbed by resin, concentrated by vacuum, microfiltered, crystallized and centrifugated, and then is dried to obtain the glucosamine hydrochloride.

Description

technical field [0001] The method belongs to a natural product extraction method, and in particular relates to a production process for hydrolyzing and separating glucosamine hydrochloride from citric acid residue. Background technique [0002] D-glucosamine hydrochloride (D-Glucosamine Hydrochloride), also known as glucosamine hydrochloride, scientific name is 2-amino-2-deoxy-D-glucose hydrochloride, molecular formula is: C 6 h 13 NO 5 ·HCl, molecular weight 215.63, CAS number: 66-84-2, structural formula: [0003] [0004] Raw materials rich in chitin or chitosan can be hydrolyzed with hydrochloric acid to produce D-glucosamine hydrochloride. D-glucosamine hydrochloride is white granular crystal, very soluble in water, insoluble in ethanol. D-glucosamine hydrochloride is widely used in drug synthesis, can be used as an anti-bacterial infection and immune adjuvant, and is an activator of human anti-influenza virus. It can promote the synthesis of chondrocyte proteog...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H5/06C07H1/08
Inventor 曹礼群蒋永红余远明李五洲魏献忠王建
Owner 技源生物制品(徐州)有限公司
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