Application of 5' nucleotide in preparation of medicines and health-care foods for alleviating physical fatigue

A technology for relieving physical fatigue and health food, which is applied in the fields of 5' nucleotide products and their new uses, health food, and the preparation of medicines for relieving physical fatigue, and can solve problems such as unreported nucleotides.

Inactive Publication Date: 2009-10-21
珍奥集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, as nutritional factors with immunomodulatory effects, many countries including China have allowed the addition of nucleotides to infant formula milk powder, but there is no report on the role of nucleotides in alleviating physical fatigue

Method used

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  • Application of 5' nucleotide in preparation of medicines and health-care foods for alleviating physical fatigue
  • Application of 5' nucleotide in preparation of medicines and health-care foods for alleviating physical fatigue
  • Application of 5' nucleotide in preparation of medicines and health-care foods for alleviating physical fatigue

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0011] Example: Experimental Research on 5' Nucleotides Relieving Physical Fatigue

[0012] 1. Materials and methods

[0013] 1. Sample: 5' nucleotide (5'AMP: 5'CMP: 5'GMPNa 2 : 5'UMPNa 2 =22.8∶26.6∶30.2∶20.4), production process: heat denaturation of ribonucleic acid (RNA) with a purity of 90% → enzymatic hydrolysis with nuclease P1 → ultrafiltration → adsorption on anion resin → stepwise elution → nanofiltration desalination → Thin film concentration → carbon powder decolorization → crystallization → drying.

[0014] 2. Experimental animals: 160 healthy and clean ICR male mice, weighing 16-20g, provided by the Experimental Animal Center of Peking University Health Science Center. , The temperature range of the feeding environment is 25±1°C, and the relative humidity is 50% to 60%RH.

[0015] 3 Main instruments and reagents: Olympus AU400 automatic biochemical analyzer (Japan); serum urea nitrogen determination kit (provided by Daiichi Chemical Co., Ltd.), anthrone reagen...

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Abstract

The invention relates to an application of 5' nucleotide in preparation of medicines and health-care foods for alleviating physical fatigue. The nucleotide is 5' nucleotide mixture which takes ribonucleic acid (RNA) as raw material, produced by enzymic degradation, has the purity of more than 99%, and is prepared by mixing 5' AMP, 5' CMP, 5' GMPNa2 and 5' UMPNa2 according to the mixture ratio of 22.8:26.6:30.2:20.4. The nucleotide can reduce and prolong the mouse burden swimming time, decreases the generation of blood lactate after movement, lowers the serum urea nitrogen level and has the function of alleviating physical fatigue.

Description

technical field [0001] The invention relates to a 5' nucleotide product and its new application, specifically the use of ribonucleic acid as a raw material to produce 5' nucleotides through enzymatic degradation in the preparation of drugs for relieving physical fatigue and health food. It belongs to the field of medicine and food health care. Background technique [0002] A global survey by the World Health Organization shows that only 5% of people are healthy, 20% are suffering from diseases, and 75% are in a sub-healthy state. Sub-health is also known as the third state, also known as gray state, pre-disease state, subclinical stage, incubation period, etc. It is a state between health and disease, with no clinical symptoms or mild symptoms, but underlying pathology The main manifestation of which is chronic fatigue syndrome (CFS). CFS is a syndrome dominated by non-specific manifestations such as fatigue, low-grade fever (or conscious fever), sore throat, myalgia, arth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/708A61K31/7076A61K31/7072A61K31/7068A61P3/02A23L1/30C12P19/30A23L33/13
Inventor 李恕李勇董锋
Owner 珍奥集团股份有限公司
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