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Application of traditional Chinese medicine composition in preparing antihypoxic

A technology of composition and traditional Chinese medicine, which is applied in the application field of traditional Chinese medicine composition in the preparation of anti-hypoxic drugs, and can solve problems such as the application of undisclosed traditional Chinese medicine composition

Active Publication Date: 2009-10-21
HEBEI YILING MEDICINE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above two patents do not disclose the application of the traditional Chinese medicine composition in the preparation of anti-hypoxic drugs

Method used

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  • Application of traditional Chinese medicine composition in preparing antihypoxic
  • Application of traditional Chinese medicine composition in preparing antihypoxic
  • Application of traditional Chinese medicine composition in preparing antihypoxic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] a) The raw material drug formula is:

[0045] Ginseng 39.6g Leech 72.6g Wood Beetle 46.2g Frankincense (made) 13.2g

[0046] Paeoniae Rubra 33g Dalbergia 13.2g Sandalwood 13.2g Scorpio 19.8g

[0047] Cicada slough 46.2g centipede 6.6g borneol 33g Suanzaoren (stir-fried) 33g;

[0048] b) Crushing process of medicinal materials:

[0049] The scorpion, leech, centipede, ground beetle, and cicada slough five kinds of insect medicines have been cleaned, washed and processed, and the frankincense prepared after cleaning is prepared according to the prescription, and crushed by a pulverizer, and the fineness of the powder reaches more than 80 mesh; The powdered medicine is ultrafinely pulverized by various ultrafine pulverization techniques, so that the average particle size of the medicine powder is less than 30-40 μm; the medicinal materials to be pulverized are washed, dried and sterilized, and the ingredients are prepared;

[0050] c) Extraction concentration and drying...

experiment example 1

[0056] Experimental Example 1 is a classic test of the main pharmacodynamics of anti-hypoxic drugs, which can confirm whether the drug has an anti-hypoxic effect.

[0057] Experimental example 2 and experimental example 3 are to carry out clinical test with the medicine of the present invention, and these two tests prove that the medicine has therapeutic and preventive activity for various diseases caused by altitude sickness and hypoxia operation.

[0058] Experimental example 1:

[0059] 1 Materials and methods

[0060] 1.1 Experimental animals: Healthy KM mice, half male and half female, weighing 26-28 g, were purchased from the Experimental Animal Center of Hebei Province, license number: SCXK (Ji) 2003-1-003. Animal identification was marked with 5% picric acid, and mice were kept in cages, 5 mice / cage. Rats were fed full-price pellets and adequate drinking water was maintained. Adaptive feeding for three days.

[0061] 1.2 Main drug: the drug of the present invention...

experiment example 2

[0075] 1 Materials and methods

[0076] 1.1 General information All cases are all selected from the inpatients of Golmud Railway Hospital in Qinghai Province, a total of 85 cases, randomly divided into two groups of drug group of the present invention and control group. The medicine group of the present invention includes 43 cases, including 40 males and 3 females, with an average age of 40 years, 6 cases of acute altitude sickness, 6 cases of high-altitude cerebral edema, 8 cases of high-altitude pulmonary edema, 3 cases of high-altitude heart disease, and 2 cases of high-altitude hypertension , 1 case of high altitude hypotension, 8 cases of high altitude polycythemia, 9 cases of mixed type of chronic high altitude sickness; 42 cases of control group, including 39 males and 3 females, with an average age of 39 years, 4 cases of acute high altitude sickness, high altitude cerebral edema 6 cases, 10 cases of high-altitude pulmonary edema, 2 cases of high-altitude heart disease...

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Abstract

The invention discloses an application of traditional Chinese medicine composition in preparing antihypoxic. The medicament mainly contains ginseng, leech, scorpion, woodlouse, chilopod, cicada ecdysis, red paeonia, sandalwood, dalbergia wood, frankincense, wild jujube and borneol and is prepared perfectly by modern pharmaceutical technique. Tests prove that the traditional Chinese medicament composition can remarkably prolong the survival time of a mouse absence of oxygen and can improve the hypoxia-resistant ability of organism.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition. Specifically, the invention relates to an application of a traditional Chinese medicine composition in preparing anti-hypoxic drugs, which belongs to the field of traditional Chinese medicine applications. Background technique [0002] Hypoxia is the most common damage factor in the body. It destroys the aerobic respiration of cells, damages the oxidative phosphorylation of mitochondria, reduces or stops the production of ATP, and causes a series of damage changes. It is an important pathophysiological factor for many diseases. Mild hypoxia mainly causes the compensatory response of the body, causing accelerated breathing, increased cardiac output, and redistribution of blood to ensure the blood supply to vital organs; when the body is incompletely compensated for severe hypoxia, the changes appear in the form of metabolic dysfunction Mainly; in acute hypoxia, sev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61K9/20A61K9/48A61K9/14A61K9/10A61K9/16A61P9/00A61P9/12A61P9/02A61P7/10A61P43/00A61K35/64A61K31/045A61K35/62A61K35/646A61K35/648
Inventor 吴以岭
Owner HEBEI YILING MEDICINE INST
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