Oral solid medicine composition containing ropinirole

A composition and drug technology, applied in the direction of drug combination, drug delivery, pharmaceutical formulation, etc., to achieve the effect of simple process, good stability, and uniform content

Active Publication Date: 2009-11-11
AVENTIS PHARMA HAINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention prepares an oral solid pharmaceutical composition of ropinirole, which effectively solves the shortcomings of the existing ropinirole preparations, and simultaneously solves the stability problem of the main drug in the preparation in a specific way

Method used

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  • Oral solid medicine composition containing ropinirole
  • Oral solid medicine composition containing ropinirole
  • Oral solid medicine composition containing ropinirole

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017]

[0018] Preparation:

[0019] Add the prescribed amount of ropinirole hydrochloride into an appropriate amount of water, dissolve it, and use it as a wetting agent; add the above wetting agent to the prescribed amount of lactose, stir, and granulate with 16 mesh; ventilate and dry at 50°C, and granulate with 20 mesh. Mix it with microcrystalline cellulose to make blank granules, add croscarmellose sodium and magnesium stearate, mix well, press into tablets to make plain tablets, make OPADRY II 85G into a 15% aqueous solution, and coat Weight gain to 3%, that is.

Embodiment 2

[0021]

[0022] Preparation:

[0023] Recipe amount ropinirole hydrochloride, and 20g microcrystalline cellulose are crossed 80 mesh sieves respectively, mix to obtain mixture I, the microcrystalline cellulose of surplus, mannitol, starch mix, make blank granule with water as wetting agent, Ventilated and dried at 50°C, granulated with 20 mesh. Mix it with the mixture I prepared above, add low-substituted hypromellose and magnesium stearate, mix evenly, press into tablets to make plain tablets, make OPADRY II 85G into a 15% aqueous solution, and coat the weight gain to 3 %, that is.

Embodiment 3

[0025]

[0026] Preparation:

[0027] The prescription amount of ropinirole hydrochloride, dextrin, and lactose were passed through an 80-mesh sieve respectively, and mixed to obtain mixture I. Starch, calcium hydrogen phosphate, and 50% crospovidone were mixed to prepare blank granules, and 20-mesh whole granules were prepared. Mix with the mixture I prepared above, add the remaining amount of crospovidone and micropowder silica gel, mix evenly, press into tablets to obtain plain tablets, prepare OPADRY II 85G into a 15% aqueous solution, and increase the weight of the coating to 3%. Instantly.

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Abstract

The invention discloses an oral solid medicine composition containing ropinirole. The oral solid medicine composition comprises a medicine containing part and hollow white granules, wherein the medicine containing part contains ropinirole and pharmaceutically acceptable carriers, and the hollow white granules contain no ropinirole and are formed by mixing pharmaceutically acceptable carriers. Theoral solid medicine composition can be prepared with simple process, has better uniformity of preparation content and stability and can be used for treating parkinson disease (PD).

Description

technical field [0001] The invention relates to an oral solid pharmaceutical composition for treating Parkinson, in particular to an oral solid pharmaceutical composition containing ropinirole and a preparation method thereof. Background technique [0002] Parkinson's disease (PD) is a common middle-aged and elderly neurodegenerative disease, and its incidence is increasing year by year with the aging of the population. Ropinirole is a selective non-ergoline dopamine D2 receptor agonist, which can directly act on the post-synaptic receptor to generate continuous stimulation, thereby alleviating the movement fluctuation of L-Dopa and reducing its difficulty in movement. Reduce the amount of L-Dopa used. Approved by the FDA in 1997, it is clinically used to control the symptoms of PD and is used in different stages of PD. [0003] CN 1712002A discloses a ropinirole hydrochloride osmotic pump controlled-release preparation and a preparation method thereof. The osmotic pump co...

Claims

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Application Information

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IPC IPC(8): A61K31/4045A61K9/20A61K9/30A61P25/16
Inventor 尚丽霞
Owner AVENTIS PHARMA HAINAN
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