Novel process for producing valine

Abstract

The invention discloses a novel process for producing valine, which comprises the following steps: obtaining a valine zymotic fluid by a microbiological fermentation method, removing impurities such as thalli through an ultrafiltration membrane, concentrating and crystallizing to obtain a crude product of the valine, and performing spray drying on mother solution to produce a feed grade product; performing acid dissolution and recrystallization on the crude product of the valine, dissolving the obtained product by 10 to 15 times of water, then producing a pharmaceutical product through ion exchange treatment, decolorization by an eluent and crystallization, and then circularly using a mother solution through the ion exchange treatment; and diluting the mother solution obtained after the re-crystallization of the crude product, then producing a food grade product through ion exchange by the mother solution, and then circularly using the mother solution through the ion exchange treatment. The process greatly improves the total extraction yield of products, produces different levels of products to meet different demands of the market, and reduces environmental pollution by recoveringand reutilizing partial wastewater generated during the ion exchange.

Description

technical field [0001] The invention belongs to the technical field of amino acid production and relates to a new process for producing valine. Background technique [0002] As one of the branched chain amino acids, L-valine is mainly used in the preparation of compound amino acid infusions, synthetic polypeptide drugs and food antioxidants, etc., especially in medical research and treatment. With continuous deepening, its scope of application in the food and feed industry will be further expanded. At present, valine is basically produced by microbial fermentation. The extraction method: abroad, represented by Ajinomoto, adopts precipitation method to extract. According to the specific combination of precipitant and valine, a precipitate is formed, and then separated and extracted. This method has the advantages of extraction yield. However, there are technical problems of environmental pollution; domestically, the ion exchange method is mainly used for the extraction of va...

AI Technical Summary

Problems solved by technology

At present, valine is basically produced by microbial fermentation. The extraction method: abroad, represented by Ajinomoto, adopts precipitation method to extract. According to the specific combination of precipitant and valine, a precipitate is formed, and then separated and extracted. This method has the advantages of extraction yield. However, there are technical problems of environmental pollution; domestically, the ion exchange method is mainly used for the extraction of valine, and the pH value of the fermented liquid after removing bacteria is lowered, and 732 cation exchange resin is used to separate valine And associated heteroacids, because the properties of associated heteroacids and valine are similar, generally 3-5 ion exchange columns are used for serial extraction, which leads to a large amount of waste water in the production process, and the product yield is low, generally at 60% Left and right, improper operation can easily cause fluctuations in product quality. In the production process, the quality of the finished product is often used to determine its grade and price, making production in a passive position.

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