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Agent and method for preventing and treating intoxication by alcohol-containing liquids and alcohol substitutes

An antidote and toxicity technology, applied in the field of medicine, can solve problems such as cell metabolic acidosis

Inactive Publication Date: 2014-06-25
谢尔盖·米哈伊洛维奇·泽诺维奇 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to this, the formation of oxyacetic acid from ethylene glycol monoethers also leads to metabolic acidosis of the cells

Method used

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  • Agent and method for preventing and treating intoxication by alcohol-containing liquids and alcohol substitutes
  • Agent and method for preventing and treating intoxication by alcohol-containing liquids and alcohol substitutes
  • Agent and method for preventing and treating intoxication by alcohol-containing liquids and alcohol substitutes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 2

[0209] Example 1. Sodium dimercaptopropanesulfon tablets

[0210] Mix 25g sodium dimercaptosulfonate (powdered substance), 5g lactose, 10g silica aerogel, 30g starch, 5g sodium starch glycolate, 5g magnesium stearate, 1g calcium pantothenate, 7g folic acid, and moisten the resulting mixture , Stir well, homogenize and compress to obtain 0.5g tablets.

[0211] Tablet formulation

[0212]

Embodiment 2

[0213] Example 2. A fast-dissolving capsule filled with particles, which includes:

[0214] ingredient mg Dimercaptopropanol 50 Dimercaptosuccinic acid 50 Sodium dimercaptosulfonate 100 Succinic acid 100 Calcium Citrate 100 Lecithin 50 Magnesium Oxide 50 Pyridoxine Hydrochloride 20

[0215] The particles are manufactured according to techniques known in pharmacological technology.

[0216] The applications used for the purposes described above have been tested with laboratory animals. The applicant took the initiative to study the detoxification behavior of ortho-ethanedithiols (using sodium dimercaptosulfonate as an example).

Embodiment 3

[0217] Example 3. The experimental part of this work was performed with male rats of the Wistar-100 strain with an initial weight of 150-250 g. These animals were reared under artificial light (12 hours per day) and freely exposed to standard compound feed and water.

[0218] These animals were divided into 4 groups (3 experimental groups, 1 control group). Before the experiment, each group was tested for biochemical blood indicators: triglycerides, liver enzymes: alanine aminotransferase (AlAT) of the strength of the peroxide process, or serum alanine aminotransferase (SGPT) and aspartame Acid aminotransferase (AsAT) indicator-TBA-positive product (detected with thiobarbituric acid), and indicators of the biological antioxidant system: uric acid, vitamin E, A; SH group.

[0219] In the first experimental group (EG1), animals were poisoned without prevention or treatment; these animals were given a placebo in the form of gelatin capsules within one hour. In the second experimenta...

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Abstract

The invention relates to medicine and can be used for developing agents and methods to be used in toxicological practice and by population at home for preventing and reducing risks of dangerous diseases such as intoxication by alcohol substitutes and toxic components of alcoholic beverages. The invention is based on the use of known chemical compounds in the form of vicinal dithioglycoles. They are used for new purposes, namely for developing medicinal agents, the properties of which make it possible to prevent, treat or reduce speed of pathological processes generated by alcohol substitute intoxication. The inventive agents reduce or block the pharmacological effects of alcohols and the derivatives thereof, i.e. produce a direct effect on pathogenetic mechanisms of intoxication development. Said agents are most efficient when perorally administered. Experimental data items proving that the inventive agents and the preventing method, which consists in taking the agents before and after drinking low-quality alcohol-containing beverages and alcohol substitutes, can be widely used in future are also disclosed. The use of the invention makes it possible to reduce the number of intoxication cases produced by substitutes, to decrease the severity of intoxication and the toxic effect of alcoholic beverages consumed at home.

Description

Technical field [0001] The present invention relates to the field of medicine, and relates to drugs used in toxicological practice, and also relates to drugs used as a preventive agent in the case of household use of alcoholic beverages including the risk of poisoning. [0002] The increasing number of poisonings associated with voluntary use of alcoholic beverages and alcoholic beverages (whether taken intentionally or accidentally) and the abuse of alcohol substitutes are becoming serious medical and social problems. According to official data, thousands of people die every year due to this type of poisoning in the Russian Federation alone. In general, medically registered cases of poisoning have been caused by the use of certain poisons and ethanol. Beverages often contain these poisons due to their inadequate purification quality, or because they are not intended to be used as edibles as a whole. It is known that non-ethanol alcohol additives increase ethanol toxicity when us...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/095A61P25/32
CPCA61K31/095A61P25/32A61P39/02
Inventor 谢尔盖·米哈伊洛维奇·泽诺维奇
Owner 谢尔盖·米哈伊洛维奇·泽诺维奇
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