Aryl sulfamide derivatives and methods of their use

A technology of heteroaryl and alkyl, applied in the field of arylsulfonamide derivatives
CN101600701AInactive Publication Date: 2009-12-09WYETH LLC
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
WYETH LLC
Publication Date
2009-12-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is directed to aryl sulfamide derivatives of formula (I): or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof, which are monoamine reuptake inhibitors, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions, including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal disorders and genitourinary disorder, depression disorders, endogenous behavioral disorders, cognitive disorders, diabetic neuropathy, pain, and other diseases or disorders.
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Description

Technical field

[0001] The present invention relates to arylsulfonamide derivatives as monoamine reuptake inhibitors, compositions containing these derivatives, and their use in the prevention and treatment of vasomotor symptoms, depression, intrinsic behavioral disorders, and cognitive disorders , Sexual dysfunction or painful conditions, especially diseases or conditions with vasomotor symptoms. Background technique

[0002] Vasomotor symptom (VMS) (called hot flashes and night sweats) is the most common symptom associated with menopause. After natural or surgically induced menopause, 60% to 80% of all women will This symptom appears. VMS may be an adaptive response of the central nervous system (CNS) to the decline of sex steroid hormones. So far, the most effective treatment for VMS is hormone-based therapy, including estrogen and / or some progesterone. Hormone therapy is extremely effective in reducing VMS, but it is not suitable for all women.

[0003] VMS is caused by fluct...

Claims

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