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Ciclesonide aerosol and preparation method thereof

A ciclesonide and aerosol technology, which is applied in the field of ciclesonide aerosol and its preparation, and achieves the effects of great application value, convenient taking and less adverse reactions

Inactive Publication Date: 2010-01-06
上海欧米尼医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the above-mentioned disadvantages, research and design a ciclesonide aerosol with quick effect, good curative effect, convenient taking and few adverse reactions

Method used

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  • Ciclesonide aerosol and preparation method thereof
  • Ciclesonide aerosol and preparation method thereof
  • Ciclesonide aerosol and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Material amount (g)

[0028] According to the prescribed amount, ciclesonide, lecithin, and absolute ethanol were mixed and stirred to form a solution, and the solution was quantitatively injected into an unsealed aerosol bottle, and the 50 μl quantitative valve was grasped and sealed on the bottle mouth. The propellant HFA 134a is then dosed into aerosol bottles by pressurized filling. Install an actuator with an orifice diameter of 0.4mm. The amount of each spray is 59.63mg, and the amount of main drug per spray is 100.0μg.

Embodiment 2

[0030] Material amount (g)

[0031] Absolute ethanol

[0032] Mix and stir ciclesonide, oleic acid, absolute ethanol, and propellant 134a according to the prescribed amount to form a solution, and quantitatively pour the solution into an aerosol bottle with a 63 μl quantitative valve that has been grasped and sealed by pressurized filling . Install an actuator with an orifice diameter of 0.4mm. The amount of each spray is 76.44mg, and the amount of main drug per spray is 94.5μg.

Embodiment 3

[0034] Material amount (g)

[0035] According to the prescribed amount, ciclesonide and absolute ethanol were mixed and stirred to form a solution, and the solution was quantitatively injected into an unsealed aerosol bottle, and the 50 μl quantitative valve was grasped and sealed on the bottle mouth. The propellant HFA 227 is then dosed into aerosol bottles by pressurized filling. Install an actuator with an orifice diameter of 0.4mm. The amount of each spray is 69.08mg, and the amount of main drug per spray is 50.0μg.

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PUM

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Abstract

The invention provides a ciclesonide aerosol comprising the following components by weight percent: 0.07-0.90 percent of ciclesonide, 0-20 percent of latent solvents and / or cosolvents, 0-2 percent of surface active agents and 77.13-99.90 percent of propellants. The ciclesonide aerosol can be a solution type aerosol or a suspension type aerosol and has the advantages of quick effect, good treatment effect, convenient use, little adverse reaction, simple and convenient preparation method and greater application value.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a ciclesonide aerosol and a preparation method thereof. Background technique [0002] The pharmaceutical aerosol system is a pressure package consisting of a valve, a container, and contents (including drugs, additives, propellants, etc.). When the valve is opened, the contents are released at a predetermined pressure and in a controlled manner. The means of controlled release include quantitative and non-quantitative. In 1956, Riker et al. applied quantitative valves for the first time and released aerosols for inhalation, which gave full play to the advantages of this dosage form. Quantitative aerosols are mostly used for systemic or local treatment after inhalation, and their dosage forms include solution aerosols and suspension aerosols. The aerosols used for the treatment of respiratory diseases are restricted by devices, prescriptions, and preparation processes. Usually, on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/58A61K47/34A61K47/12A61K47/24A61P11/06A61P29/00
Inventor 张凯王晓飞
Owner 上海欧米尼医药科技有限公司
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