Silver-containing pig acellular dermis and method for preparing same

A cell-free, pigskin technology, applied in medical science, prosthesis, etc., can solve the problem of high incidence of infection, and achieve the effect of reducing the incidence of infection

Inactive Publication Date: 2010-01-06
CHONGQING ZONGSHEN JUNHUI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a silver-containing porcine acellular dermis and its preparation method, which can effectively solve the existing defects of high incidence of infection after transplantation of porcine acellular dermis

Method used

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  • Silver-containing pig acellular dermis and method for preparing same
  • Silver-containing pig acellular dermis and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

no. 1 example

[0041] Step 101. Select 4-month-old Bamaxiang pig skin as the raw pigskin, and perform an appearance inspection on the raw pigskin. The raw pigskin is normal white, the skin surface is smooth and flat, and the fur has no blood stasis and common skin diseases. Capillary and few, small pores;

[0042] Step 102. Scrub the front and back sides of the pigskin after inspection with soap powder water three times until clean, remove the unclean parts such as corner waste and large pieces of fat, then scrub the pigskin with 3% iodophor by weight, and finally use a large amount of water wash;

[0043] Step 103, first use a sharpener to roughly shave the pigskin after brushing, rinse the pigskin with clean water, then shave the pigskin finely with a small razor, and scrub with clean water;

[0044] Step 104: Thinning the shaved pigskin, removing subcutaneous fat, and obtaining a skin slice, using a drum skin remover to cut off the epidermis and subcutaneous tissue, leaving only the derm...

no. 2 example

[0050] Step 201, select the skin of 5-month-old Bamaxiang pig as the raw pigskin, and perform an appearance inspection on the raw pigskin. The raw pigskin is normal white, the skin surface is smooth and flat, the fur has no blood stasis, and there is no common skin disease. Capillary and few, small pores;

[0051] Step 202, scrub the front and back sides of the pigskin after inspection with soap powder water four times until clean, remove the unclean parts such as corner waste and large fat, then scrub the pigskin with 5% iodophor by weight, and finally use a large amount of wash with water;

[0052] Step 203, first use a sharpener to roughly shave the pigskin after brushing, rinse the pigskin with clean water, then shave the pigskin finely with a small razor, and scrub with clean water;

[0053] Step 204, Thin the shaved pigskin, remove the subcutaneous fat, and obtain a skin slice, use a drum skin remover to cut off the epidermis and subcutaneous tissue, leaving only the de...

no. 3 example

[0059] Step 301. Select 6-month-old Bamaxiang pig skin as the raw pigskin, and perform an appearance inspection on the raw pigskin. The raw pigskin is normal white, the skin surface is smooth and flat, and the fur has no blood stasis and common skin diseases. Capillary and few, small pores;

[0060]Step 302, scrub the front and back sides of the pigskin after inspection with soap powder water five times until it is clean, remove the unclean parts such as corner waste and large pieces of fat, then scrub the pigskin with 8% iodophor by weight, and finally use a large amount of wash with water;

[0061] Step 303, shave the pigskin roughly with a grinder, rinse the pigskin with clean water, then shave the pigskin finely with a small razor, and scrub with clean water;

[0062] Step 304, Thinning the shaved pigskin, removing the subcutaneous fat, and obtaining a skin slice, using a drum skin remover to cut off the epidermis and subcutaneous tissue, leaving only the dermis with a th...

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Abstract

The invention relates to silver-containing pig acellular dermis and a method for preparing the same. The method for preparing the silver-containing pig acellular dermis comprises steps of pretreating pigskin; splitting the pigskin; sterilizing a skin sheet; performing cell removing treatment on the skin sheet; and performing active silver solution treatment on the skin sheet. The invention relates to silver-containing pig acellular dermis prepared by the method for preparing the silver-containing pig acellular dermis. Because of the treatment of the active silver ion solution, the silver-containing pig acellular dermis of the invention has active bacteria inhibiting effect , and reduces infection occurrence rate after transplantation; meanwhile, the silver-containing pig acellular dermis of the invention not only removes the prior immunogenicity cell components in the matrix, but also maintains a basic structure of skin tissue and an integral collagen fiber support, contains silver ions with bacteria inhibiting effect at the same time, and provides a fine dermis substituent with active bacteria inhibiting function in clinic application.

Description

technical field [0001] The invention relates to the field of tissue engineering, in particular to a silver-containing porcine acellular dermis and a preparation method thereof. Background technique [0002] In the process of treating patients with extensive burns, how to use limited skin sources to seal the wound as early as possible is one of the more difficult problems to solve. In clinical practice, micro-skin or epidermal cell culture transplantation is sometimes used to expand the coverage area of ​​the skin source so that the wound can be closed as soon as possible. Although these skin sources can seal the wound surface, due to the lack of support of dermal components, the healing rate is low, and even serious additional symptoms such as blisters, ulceration, and scar contractures appear. [0003] At present, a large number of researchers have carried out various research work on providing support for epidermal cells and improving the quality of wound healing. After ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/60A61L27/50
Inventor 魏泓葛良鹏吴军
Owner CHONGQING ZONGSHEN JUNHUI BIOTECH
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