Pharmaceutical composition containing deer bone extractive and melon seed extract
A composition, the technology of melon seeds, applied in the field of pharmaceutical composition for injection and its preparation, can solve the problems of high energy consumption and cost, complicated operation, unfavorable industrialization implementation, etc.
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Embodiment 1
[0038] (1) Preparation of deer bone extract: Take 20kg of fresh healthy deer bone, remove the connective tissue on the surface, wash it, break it into small pieces, add water for injection (ie 60kg) with 3 times the weight, and put it at 121°C under 0.1MPa pressure Extract for 3 hours, filter and collect the filtrate. In the same way, the filter residue was hot-pressed, filtered, and the filtrate was collected, and the filtrate obtained twice was combined. Add 3 mol / L hydrochloric acid aqueous solution to the combined filtrate to adjust the pH value to 4.0, then freeze the filtrate at -5°C for 16 hours, filter, collect the filtrate, then heat the filtrate to 100°C, perform ultrafiltration, collect the filtrate, and The filtrate was centrifuged and the supernatant was collected. Add 3 mol / L sodium hydroxide aqueous solution to the supernatant to adjust the pH to 10.0, place at room temperature for 1 hour, filter, collect the filtrate, centrifuge the filtrate, and collect the s...
Embodiment 2
[0042] (1) Preparation of deer bone extract: take 50 kg of fresh healthy deer bone, remove the connective tissue on the surface, wash, break into small pieces, add 4 times the weight of water for injection (ie 200 kg), at 121 ° C, 0.1 MPa pressure Extract for 4 hours, filter, and collect the filtrate. In the same way, the filtered residue was extracted under hot pressure, filtered, the filtrate was collected, and the filtrate obtained twice was combined. Add 4 mol / L hydrochloric acid aqueous solution to the combined filtrate to adjust the pH value to 5.0, then freeze the filtrate at 0°C for 12 hours, filter, collect the filtrate, then heat the filtrate to 100°C, perform ultrafiltration, collect the filtrate, and then Centrifuge the filtrate, collect the supernatant, add 3mol / L NaOH aqueous solution to the supernatant to adjust the pH value to 11.0, place the supernatant after adjusting the pH value at room temperature for 3 hours, filter, collect the filtrate, and then centrif...
Embodiment 3
[0046] (1) Preparation of deer bone extract: take 100 kg of fresh healthy deer bone, remove the connective tissue on the surface, wash it, break it into small pieces, add 5 times the weight of water for injection (ie 500 kg), and put it at 121 ° C under a pressure of 0.1 MPa Extract for 5 hours, filter, and collect the filtrate. In the same way, the filter residue was hot-pressed, filtered, and the filtrate was collected, and the filtrate obtained twice was combined. Add 5 mol / L hydrochloric acid solution to the combined filtrate to adjust the pH value to 6.0, then freeze the combined filtrate at -5°C for 24 hours, filter, collect the filtrate, then heat the filtrate to 100°C, perform ultrafiltration, and collect the filtrate. Then the filtrate was centrifuged, and the supernatant was collected. Add 5 mol / L sodium hydroxide aqueous solution to the supernatant to adjust the pH value to 11.0, place at room temperature for 4 hours, filter, collect the filtrate, centrifuge the fi...
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