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Application of cobrotoxin in preparing medicine for treating arthritis

A technology of neurotoxin and cobra, applied in the direction of drug combination, antipyretics, anti-inflammatory agents, etc., to achieve a large effective range, less dosage, and improve the effect of pathological changes in bone joints and synovium

Inactive Publication Date: 2010-02-17
ZHEJIANG JINGXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the treatment of rheumatoid arthritis with cobra short-chain neurotoxin (Cobrotoxin). We first found that it has a good anti-rheumatic arthritis effect

Method used

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  • Application of cobrotoxin in preparing medicine for treating arthritis
  • Application of cobrotoxin in preparing medicine for treating arthritis
  • Application of cobrotoxin in preparing medicine for treating arthritis

Examples

Experimental program
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Effect test

Embodiment

[0012] Example: According to the animal experiment results of cobra short-chain neurotoxin (Cobrotoxin) in the treatment of rheumatoid arthritis, and the situation that cobra short-chain neurotoxin (Cobrotoxin) can be made into cataplasm. When the present invention treats arthritis, cataplasms can be used, 0.1-10 mg / paste, and pasted on diseased joints once every two days.

[0013] Research findings supporting the present invention:

[0014] 1. Cobrotoxin (Cobrotoxin, 1-100 μg / kg) intraperitoneal injection can reduce the ankle joint circumference of rats with primary adjuvant arthritis and increase the mechanical pain threshold of rats.

[0015] 2. Cobrotoxin (Cobrotoxin, 1-100 μg / kg) intraperitoneal injection can reduce the ankle joint circumference of rats with secondary adjuvant arthritis and increase the mechanical pain threshold of rats.

[0016] 3. Cobrotoxin (Cobrotoxin, 1-400 μg / kg) intragastric administration can reduce the ankle joint circumference of rats with prim...

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Abstract

The invention discloses an application of cobrotoxin in preparing a medicine for treating arthritis. Cobrotoxin is a neurotoxin purified from Chinese cobra-venom. People research discovers that the cobrotoxin in the range of 1-600mug / kg has obvious effect on treating rheumatoid arthritis, can relieve the symptoms of arthrocele, arthralgia and the like, and has the advantages of small dose, safety,capability of oral administration, injectability, administration through oral mucous membrane, nasal mucous membrane and skin, and the like.

Description

technical field [0001] The invention relates to the use of cobra short-chain neurotoxin (Cobrotoxin) in the preparation of medicaments for treating arthritis. Background technique [0002] Snake venom is a complex mixture of components secreted by the snake's venom glands. More than 90% of the dry matter of snake venom is protein, which is the main component of its toxicity and its biological activity. The traditional medicine of the motherland believes that cobra and its poisonous components can clear the meridians, dispel rheumatism, and have the effect of strengthening the body. As early as the beginning of the 20th century, people began to use snake venom to relieve malignant tumor pain, neuralgia and joint pain. A series of reports on the morphine-like analgesic effect of snake venom. With the continuous deepening of research, now, snake venom and its products have been used clinically. In addition to analgesic effect, they have good curative effects in anti-rheumatis...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P19/02A61P29/00
CPCA61K38/17A61K35/58A61P19/02A61P29/00
Inventor 秦正红刘艳丽邹容
Owner ZHEJIANG JINGXIN PHARMA
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