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Medicinal composition for treating eye diseases and application thereof

A composition and drug technology, applied in the field of pharmaceutical compositions for asthenopia, treatment of pre-screen syndrome and dry eye syndrome, can solve problems such as the lack of clear active ingredient groups in collagen, and achieve a good therapeutic effect.

Inactive Publication Date: 2010-02-17
安徽省华鼎生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the patent application for collagen eye drops (application number CN200510098424.7) and the patent application for composite collagen eye drops (application number CN200510098425.1), the collagen used is not clear about the active ingredient group, but according to The preparation method of collagen in the patent shows that the collagen referred to in the patent is actually collagen

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Prescription: Collagen Extract 300ml (Contains Collagen 3.0g)

[0027] Preparation method: Take 0.5g of sodium hyaluronate, add 600ml of water for injection to moisten for 24 hours, add 300ml of collagen solution, 12g of boric acid, 0.6g of borax, 0.8g of ethylparaben, stir until clear, heat to 70°C, Filter, add water for injection to 1000g, pass through a microporous membrane (0.22μm), and aseptically dispense, to obtain. (Note: The collagen used is gelatin biomimetic hydrolysis with pepsin and trypsin, and then obtained by ultrafiltration with a 5kD ultrafiltration membrane)

Embodiment 2

[0029] Prescription: 100ml of collagen extract (containing 30mg of collagen) 200ml of collagen extract (containing 2.0g of collagen)

[0030] Preparation method: Take 1600ml of water for injection, add gellan gum, stir evenly, place in a boiling water bath, stir until clarified, add 24g of boric acid, 1.2g of borax, 1.2g of ethylparaben, heat to 70°C, stir until clarified, Filtrate, add collagen extract and collagen extract under stirring, add water for injection to 2000g, pass through a microporous membrane (0.22 μm), and aseptically package to obtain. (Note: The collagen used is obtained from pigskin by enzymolysis with neutral protease, and then by ultrafiltration with a 10kD ultrafiltration membrane. Cowhide is used as raw material for collagen, extracted with acetic acid solution, and obtained by enzymolysis with pepsin. The relative molecular weight is 250~285kD.)

Embodiment 3

[0032] Prescription: Radix Paeoniae Rubra 500g, Aloe Vera Gel 20g, Menthol 0.5g

[0033] Collagen extract 200ml (contains collagen 2g)

[0034] Preparation method: take Radix Paeoniae Rubra, add 8 times the amount of water to decoct twice, each time for 2 hours, filter, combine the filtrate, concentrate under reduced pressure, add ethanol to make the alcohol content reach 70%, let it stand overnight, and take the supernatant Recover ethanol under reduced pressure, put the remaining water on the AB-8 macroporous adsorption resin column, elute with water and 50% ethanol respectively, collect the 50% ethanol eluate, recover ethanol under reduced pressure until there is no alcohol smell, and use the water for later use; Add phenoxyethanol to 1000ml of water for injection that has been heated to about 80°C, stir well, add 24g of boric acid and 1.2g of borax while it is hot, stir to dissolve, let it cool, add it to the extract of Radix Paeoniae Rubra, stir well, slowly Add aloe ver...

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PUM

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Abstract

The invention discloses a medicinal composition for treating syndrome in front of screens, visual fatigue and dry eye syndrome and application thereof, and belongs to the field of Chinese medicament. The raw material medicament of effective components of the medicinal composition is collagen which can be combined with effective components of the Chinese medicament to form various eye preparations. The technical scheme creatively applies the collagen in the eye preparations so as to enlarge the application range of the collagen and achieve remarkable effect in the aspect of treating the syndrome in front of screens, the visual fatigue and the dry eye syndrome.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating pre-screen syndrome, asthenopia and dry eyes and its application, belonging to the field of traditional Chinese medicine. Background technique [0002] In the current information society, computers, TVs, game consoles and other video display terminals have penetrated into every part of our daily life, followed by more and more patients with pre-screen syndrome, visual fatigue and dry eye syndrome. Many, and has become a class of social problems. Visual fatigue is a common disease in ophthalmology at present. The symptoms of patients are various. The common ones are short-distance work cannot last long, pain in the eyes and around the eyes, blurred vision, dry eyes, tears, etc. In severe cases, headache, nausea, dizziness. It is not an independent disease, but a group of fatigue syndromes caused by various reasons. Front-of-screen syndrome refers to that due to long-term staring at th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61P27/02A61K31/045A61K31/122A61K33/30A61K35/56A61K35/62A61K35/64A61K36/185A61K36/21A61K36/232A61K36/236A61K36/258A61K36/286A61K36/482A61K36/484A61K36/486A61K36/533A61K36/536A61K36/537A61K36/56A61K36/71A61K35/32A61K35/618A61K35/646A61K35/648
Inventor 武建卓柴金苗
Owner 安徽省华鼎生物科技有限公司
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