Medicine carrying system based on nano graphene oxide

A technology of nano-graphite oxide and fossils, which is applied in the direction of drug combination, antineoplastic drugs, and pharmaceutical formulations. Effects of Drug Administration and Targeted Cytotoxicity
CN101670108AInactive Publication Date: 2010-03-17SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
Publication Date
2010-03-17
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a medicine carrying system based on nano graphene oxide, and is characterized in that the surface of the nano graphene oxide contains two hydrophilic potential groups of carboxyl and sulfonic acid group, carboxyl of the nano graphene oxide is subject to coupling with targeted molecules of folacin, polypeptide or antibody with the help of chemical cross-linker, and carbon atoms of nano graphene oxide absorb and load with one or more than one medicine molecules containing aromatic nucleus to form a targeted medicine carrying system. Proved by application in laboratories,the medicine carrying system can practically improve targeted medicine application and targeted cytotoxicity on each disease point where the medicine is applied, and provides a new thought for targeted therapy on tumor, cancer and other pathogeny.
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Description

technical field

[0001] The invention relates to a nano targeted drug carrier, in particular to a targeted drug loading system based on nano graphene oxide. Background technique

[0002] Nano-targeted drug carrier is a form of carrier for targeted therapy. The particle size is between a few nanometers and hundreds of nanometers. It uses physical (magnetic field) or biological (ligand receptor recognition, antibody antigen interaction, etc.) The drug carrier gathers at the target site and releases it stably, increasing the drug concentration at the target site and enhancing the therapeutic effect; at the same time reducing the drug distribution at other sites and reducing the side effects of the drug. Targeted drug-loading systems based on nanomaterials generally must be achieved through the following steps: first, surface modification is required to avoid agglomeration of nanomaterials. The most widely used method is to modify nanomaterials with polyethylene glycol (PEG). T...

Claims

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