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Chinese herbal formula for treating respiratory system diseases and preparation method of nano preparation of Chinese herbal formula

A technology for respiratory diseases and nano preparations, applied in the field of preparation of nano preparations, can solve the problems of human and environmental hazards, small production volume, low efficiency, etc., and achieve the effects of high safety, high bioavailability, and improved drug efficacy

Active Publication Date: 2014-04-02
FEELLIFE BIOSCI INT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, although ultra-fine pulverization technology is not limited by the solubility of traditional Chinese medicine, it has disadvantages such as low efficiency, high noise, and small production capacity; in addition to being limited by solubility, the particles obtained by spray drying method are not necessarily nano-scale; Chemical methods such as chemical precipitation will introduce chemical solvents, which will cause harm to the human body and the environment

Method used

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  • Chinese herbal formula for treating respiratory system diseases and preparation method of nano preparation of Chinese herbal formula
  • Chinese herbal formula for treating respiratory system diseases and preparation method of nano preparation of Chinese herbal formula

Examples

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Embodiment 1

[0025] The raw materials and their weight parts are 15 cassia twigs, 15 Atractylodes macrocephala, 20 chuanxiong, 10 angelica, 8 houttuynia, 5 peppermint, 5 loquat leaves, 8 artemisia annua, 8 Manshanhong, 5 peucedanum, and tangerine peel 5.

[0026] Take eleven raw materials according to the stated parts by weight, and bake them at 90°C for 180 minutes. After baking, samples are taken to measure the water content with a moisture analyzer, and the water content is controlled to be 5%. Then the roasted raw medicine is pulverized with a pulverizer, and passed through a 60-mesh sieve. Then put the crushed and sieved crude drug into the extraction kettle, and set the pressure of the extraction kettle to 50Mpa and the temperature to 50°C. Perform supercritical extraction: CO 2 The flow rate is controlled at a flow rate of 30L / hr, CO 2 After boosting the pressure and increasing the temperature to the set pressure and temperature of the extraction kettle, the volatile oil componen...

Embodiment 2

[0028] The raw materials and their weight parts are 15 cassia twigs, 15 Atractylodes macrocephala, 20 chuanxiong, 10 angelica, 8 houttuynia, 5 peppermint, 5 loquat leaves, 8 artemisia annua, 8 Manshanhong, 5 peucedanum, and tangerine peel 5.

[0029] Take eleven raw materials according to the parts by weight, and bake them at 120° C. for 30 minutes. After baking, take samples and measure their moisture content with a moisture analyzer, and control their moisture content to 10%. Then the roasted raw medicine is pulverized with a pulverizer, and passed through an 80-mesh sieve. Then put the crushed and sieved crude drug into the extraction kettle, and set the pressure of the extraction kettle to 15Mpa and the temperature to 38°C. Perform supercritical extraction: CO 2 The flow rate is controlled at a flow rate of 60L / hr, CO 2After increasing the pressure and temperature to the set pressure and temperature of the extraction kettle, the volatile oil components in the raw materi...

Embodiment 3

[0031] The raw materials and their weight parts are 15 cassia twigs, 15 Atractylodes macrocephala, 20 chuanxiong, 10 angelica, 8 houttuynia, 5 peppermint, 5 loquat leaves, 8 artemisia annua, 8 Manshanhong, 5 peucedanum, and tangerine peel 5.

[0032] Take eleven raw materials according to the stated parts by weight, and bake them at 100°C for 60 minutes. After baking, take samples and measure their moisture content with a moisture analyzer, and control their moisture content to 7%. Then the roasted raw medicine is pulverized with a pulverizer, and passed through a 100-mesh sieve. Then put the crushed and sieved crude drug into the extraction kettle, and set the pressure of the extraction kettle to 25Mpa and the temperature to 60°C. Perform supercritical extraction: CO 2 The flow rate is controlled at a flow rate of 100L / hr, CO 2 After increasing the pressure and temperature to the set pressure and temperature of the extraction kettle, the volatile oil components in the raw ...

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Abstract

The invention provides a Chinese herbal formula for treating respiratory system diseases and a preparation method of a nano preparation of the Chinese herbal formula. The Chinese herbal formula comprises the following material medicines in parts by weight: 15 parts of cassia twig, 15 parts of atractylodes rhizome, 20 parts of Ligusticum wallichii, 10 parts of Angelica sinensis, 8 parts of Houttuynia cordata, 5 parts of Mentha haplocalyx, 5 parts of folium eriobotryae, 8 parts of sweet wormwood, 8 parts of Rhododendron dauricum, 5 parts of Common hogfenneI root and 5 parts of pericarpium citri reticulatae. The method for preparing the nano preparation of the Chinese herbal formula for treating the disease of the respiratory system comprises the following five steps of: baking, smashing, sieving, supercritical extraction and micronization treatment. The Chinese herbal formula has a good effect on the treatment of respiratory system diseases, and the nano preparation prepared from the Chinese herbal formula has the characteristics of high activity, high bioavailability, good slow controlled release performance, targeted drug delivery and the like.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and relates to a preparation method of a nano-preparation of a traditional Chinese medicine composition for treating respiratory diseases. Background technique [0002] Respiratory system disease is a kind of common disease, frequently-occurring disease, and main lesion is in trachea, bronchi, lung and chest cavity. According to the data of China’s Chinese patent medicine and western medicine hospital medication monitoring and analysis system (HDM), from 2007 to 2010, the hospital use of respiratory system Chinese patent medicine showed an upward trend, with a growth rate of 17.35% (2008) and 27.84% (2009) respectively. ), 16.89% (2010). This shows that Chinese patent medicines are developing rapidly in my country's respiratory disease drug market and have great potential for development. The same data from the Hospital Drug Monitoring and Analysis System (HDM) of ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/78A61K9/08A61K9/12A61P11/00
Inventor 曾智平华健
Owner FEELLIFE BIOSCI INT
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