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Light micro-flow biosensor in inner cavity of semiconductor laser

A biosensor and semiconductor technology, applied in instruments, scientific instruments, and material analysis through optical means, can solve the problems of sensitivity limitation and short microfluidics, and achieve high sensitivity, compact device structure, and low cost

Active Publication Date: 2010-04-14
浙江兰特普光电子技术有限公司
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, due to the short length of the resonant cavity occupied by microfluidics, its sensitivity is limited to a certain extent.

Method used

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  • Light micro-flow biosensor in inner cavity of semiconductor laser
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  • Light micro-flow biosensor in inner cavity of semiconductor laser

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Embodiment Construction

[0038] Below according to accompanying drawing, describe the present invention in detail

[0039] image 3 It is an embodiment of the semiconductor laser cavity optical microfluidic biosensor of the present invention.

[0040] According to one embodiment of the present invention, the semiconductor laser intracavity optical microfluidic biosensor includes a coupled-cavity semiconductor laser composed of two mutually coupled reference resonant cavities 101 and sensing resonant cavities 102, a 2×2 coupler 9 and a set Phase adjustment area 5 on any coupler input port 1 or 2; two optical waveguide arms are respectively placed in the reference resonant cavity 101 and the sensing resonant cavity 102, and the two optical waveguides are very close at one end (closed end) , but are farther apart at the other end (open end). There is a reflective element at both ends of each optical waveguide, which can be a cleavage reflective surface or a rectangular deep etched groove, that is, resp...

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Abstract

The invention discloses a light micro-flow biosensor in an inner cavity of a semiconductor laser, which comprises a coupling cavity semiconductor laser, a 2*2 coupler and a phase regulating region arranged on an input port of the coupler. A master mold of the coupling cavity semiconductor laser is output from a coupling output port of the coupler, and a master side mold of the coupling cavity semiconductor laser is output from another coupling output port. The resonant frequency interval of a sensing resonant cavity is 1 / 2 slightly larger than or smaller than that of a reference resonant cavity. A part of the sensing resonant cavity is a sensing region, and the periphery of the sensing region is completely or partially covered by a measured substance. When the refractive index of the measured substance changes, the modes of the coupling cavity semiconductor laser are switched, the phase difference of two resonant cavity output ports has a pi phase jump, the power ratio of two output ports of a detection coupler is changed by a vernier effect, and then, the change of the refractive index of a sample can be measured. The detection limit of the biosensor reaches 10-8 and even lower magnitude.

Description

technical field [0001] The invention relates to an optical biosensor, in particular to a monolithically integrated semiconductor laser inner cavity optical microfluidic biosensor. Background technique [0002] Biochemical detection and environmental monitoring analysis have become another important application field of integrated optoelectronic devices after the great success of optical fiber communication. Optical biosensors are immune to electromagnetic field interference, have the advantages of non-destructive operation mode, high signal generation and reading speed, especially because optical sensing technology is the only method that can directly detect biomolecular reactions. The integration of optoelectronic sensors has made related instrument systems continuously develop in the direction of high integration, high sensitivity, and miniaturization, and it has also made it possible to integrate biosensor arrays for simultaneous detection of multiple parameters on a sing...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/41
CPCG01N2021/458G01N2021/0346G01N2021/399G01N21/45G01N21/7746G01N2021/391G01N21/05
Inventor 何建军虞婷婷楼敏
Owner 浙江兰特普光电子技术有限公司
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