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Method for synthesizing N-ethyl cyclohexylamine

A technology of ethylcyclohexylamine and a synthesis method, applied in the field of organic compound synthesis, can solve the problems of equipment corrosion environment, pollution, high toxicity of raw materials, etc., and achieve the effects of reducing production cost, widening sources, and realizing industrialization.

Inactive Publication Date: 2010-04-21
ZHEJIANG UNIV
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Problems solved by technology

[0008] This method usually has the advantages of high reaction selectivity and high yield; however, due to the high toxicity of the raw materials used, it does not meet the requirements of modern green chemistry, and the chloride produced during the reaction will cause corrosion of equipment and other serious environmental pollution. question

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  • Method for synthesizing N-ethyl cyclohexylamine
  • Method for synthesizing N-ethyl cyclohexylamine
  • Method for synthesizing N-ethyl cyclohexylamine

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Embodiment 1

[0024] Embodiment 1: a kind of synthetic method of N-ethylcyclohexylamine:

[0025] 1. Mix 100ml of commercially available γ-Al 2 o 3 Fill in the middle section 5 in the normal pressure fixed bed reactor 3, open the carrier gas inlet 10 and the condensing device 7, control the N 2 After the flow rate is 30L / h, turn on the heater 9, raise the temperature and control the temperature in the fixed-bed reactor 3 at atmospheric pressure to stabilize at 300°C; put the raw material formed by mixing cyclohexylamine and ether with a molar ratio of 1:1 into the syringe 1 , the top of constant pressure fixed bed reactor 3, with N 2 Commonly enter the normal pressure fixed-bed reactor 3 to carry out N-ethylation reaction, the raw material after gasification is 0.3 / h -1 The space velocity enters the γ-Al in the middle section 5 2 o 3 Reaction is carried out, and the reaction product is collected in liquid form after being condensed by the condensing unit 7, and different fraction produ...

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Abstract

The invention discloses a method for synthesizing N-ethyl cyclohexylamine. The N-ethyl cyclohexylamine is prepared by taking a normal pressure fixed bed reactor as a reaction device, and putting gamma-Al2O3 serving as a catalyst in the normal pressure fixed bed reactor; using a mixture of cyclohexylamine and diethyl ether as a raw material in a mole ratio of the diethyl ether to the cyclohexylamine of 1-5:1; gasifying the raw material after the raw material is put in the reactor, then performing reaction under an atmosphere of taking an inert gas as a carrier under the action of the gamma-Al2O3 at a normal pressure, wherein the reaction temperature is between 200 and 350 DEG C, the reaction volume space velocity v is 0.1-0.6 / h, and the volume space velocity is h-1; and after the reaction is finished, condensing and separating the obtained reaction product. The N-ethyl cyclohexylamine synthesized by the method has the characteristics of low cost, high yield and high selectivity.

Description

technical field [0001] The invention relates to a method for synthesizing organic compounds, in particular to a method for synthesizing organic pesticides and pharmaceutical intermediates-N-ethylcyclohexylamine in a normal-pressure fixed-bed reactor. Background technique [0002] Aliphatic amines and their derivatives are important chemical raw materials and pharmaceutical intermediates. Aliphatic secondary amines have the molecular structure RNHR', where R and R' are different aliphatic hydrocarbon groups or cycloalkane groups. It can be used as an epoxy curing agent or as an intermediate in the production of plant growth protection agents. The N-ethylcyclohexylamine involved in this paper belongs to a kind of aliphatic secondary amine. At present, the preparation of N-ethylcyclohexylamine with cyclohexylamine as the starting material has been reported as follows: [0003] 1), using acetonitrile and cyclohexylamine as raw materials (Journal of Organic Chemistry, 64(3), 80...

Claims

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Application Information

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IPC IPC(8): C07C211/35C07C209/16
Inventor 陈新志陈汉庚钱超
Owner ZHEJIANG UNIV
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