Baicalein phospholipid complex and preparation method thereof

A technology of baicalein phospholipids and complexes, which is applied in the direction of edible phospholipid composition, food science, organic chemistry, etc., can solve the problems of poor hydrophilicity and lipophilicity of baicalein, and achieve the effect of good stability and improved solubility

Inactive Publication Date: 2010-05-12
ZHEJIANG UNIV
View PDF0 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to address the deficiencies in the prior art, to provide a baicalein phospholipid complex and a preparation method thereof, thereby solving the technical problem that baicalein has poor hydrophilicity and lipophilicity, and improving the bioavailability of baicalein

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Baicalein phospholipid complex and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0018] The preparation method of the baicalein phospholipid complex of the present invention is as follows: take baicalein and phospholipids with a weight ratio of 1:1-6, stir in an organic solvent with a small dielectric constant at 20-80°C for 0.5-3h, and then depressurize Dry or freeze-dry, remove the organic solvent, and get the baicalein-phospholipid complex.

[0019] Wherein, the organic solvent is selected from one or more mixtures of dichloromethane, tetrahydrofuran, acetone, ethyl acetate, ethanol, and the like. Baicalein and phospholipids are mixed in an organic solvent, the reaction temperature is 20-80°C, the reaction time is 0.5-3 hours; the reaction concentration is 5-20 mg / ml; after vacuum drying or freeze drying to remove the organic solvent, baicalein is obtained Phospholipid complex.

[0020] The baicalein phospholipid complex obtained by the above method can be further purified, and the preferred purification method of the baicalein phospholipid complex is:...

Embodiment 1

[0028] Example 1: Weigh 100 mg of baicalein and 200 mg of soybean lecithin, dissolve in 20 ml of tetrahydrofuran, stir magnetically in a water bath at 40°C for 2 hours, remove the reaction solvent under reduced pressure, and dry in vacuum at low temperature to obtain a semi-solid phospholipid complex.

Embodiment 2

[0029] Example 2: 200 mg of baicalein and 800 mg of soybean lecithin were weighed, dissolved in 40 ml of ethyl acetate, magnetically stirred in a water bath at 20° C. for 2 hours, the reaction solvent was removed under reduced pressure, and vacuum-dried at low temperature to obtain a semi-solid phospholipid complex.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a baicalein phospholipid complex and a preparation method thereof. The baicalein phospholipid complex is compounded by baicalein and phospholipid, wherein the weight ratio of the baicalein to the phospholipid is 1:1-6. The invention also discloses a preparation method of the baicalein phospholipid complex. The baicalein phospholipid complex prepared by the invention can improve the hydrophilicity and lipophilicity of the baicalein, and improve the bioavailability of the baicalein.

Description

technical field [0001] The invention relates to the technical field of medicine and its preparation, in particular to a flavonoid natural active product baicalein phospholipid complex and a preparation method thereof. Background technique [0002] Radix Scutellariae (Radix Scutellariae) is the dry root of Scutel-laria baicalensis Georgi, a plant in the Labiatae family. It is bitter in taste and cold in nature. Baicalein (Baicalein, BAI) is one of the main active ingredients of Scutellaria baicalensis, its chemical structure belongs to flavonoids, and its structural formula is as follows: [0003] [0004] Studies have shown that baicalein has the following pharmacological effects: 1. Antibacterial and antiviral; 2. Inhibiting inflammation; 3. Liver protection, choleretic and diuretic; 4. Free radical scavenging and antioxidant effects; 5. Anticoagulant and antithrombotic; 6 Inhibition of pancreatic enzyme activity; 7 The effect on biofilm; 8 Anti-cancer; 9 Dual regulatio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/10C07D311/30
Inventor 金一张春燕王成润
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap