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Baicalein phospholipid complex and preparation method thereof

A technology of baicalein phospholipids and complexes, which is applied in the direction of edible phospholipid composition, food science, organic chemistry, etc., can solve the problems of poor hydrophilicity and lipophilicity of baicalein, and achieve the effect of good stability and improved solubility

Inactive Publication Date: 2010-05-12
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to address the deficiencies in the prior art, to provide a baicalein phospholipid complex and a preparation method thereof, thereby solving the technical problem that baicalein has poor hydrophilicity and lipophilicity, and improving the bioavailability of baicalein

Method used

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  • Baicalein phospholipid complex and preparation method thereof

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preparation example Construction

[0018] The preparation method of the baicalein phospholipid complex of the present invention is as follows: take baicalein and phospholipids with a weight ratio of 1:1-6, stir in an organic solvent with a small dielectric constant at 20-80°C for 0.5-3h, and then depressurize Dry or freeze-dry, remove the organic solvent, and get the baicalein-phospholipid complex.

[0019] Wherein, the organic solvent is selected from one or more mixtures of dichloromethane, tetrahydrofuran, acetone, ethyl acetate, ethanol, and the like. Baicalein and phospholipids are mixed in an organic solvent, the reaction temperature is 20-80°C, the reaction time is 0.5-3 hours; the reaction concentration is 5-20 mg / ml; after vacuum drying or freeze drying to remove the organic solvent, baicalein is obtained Phospholipid complex.

[0020] The baicalein phospholipid complex obtained by the above method can be further purified, and the preferred purification method of the baicalein phospholipid complex is:...

Embodiment 1

[0028] Example 1: Weigh 100 mg of baicalein and 200 mg of soybean lecithin, dissolve in 20 ml of tetrahydrofuran, stir magnetically in a water bath at 40°C for 2 hours, remove the reaction solvent under reduced pressure, and dry in vacuum at low temperature to obtain a semi-solid phospholipid complex.

Embodiment 2

[0029] Example 2: 200 mg of baicalein and 800 mg of soybean lecithin were weighed, dissolved in 40 ml of ethyl acetate, magnetically stirred in a water bath at 20° C. for 2 hours, the reaction solvent was removed under reduced pressure, and vacuum-dried at low temperature to obtain a semi-solid phospholipid complex.

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Abstract

The invention discloses a baicalein phospholipid complex and a preparation method thereof. The baicalein phospholipid complex is compounded by baicalein and phospholipid, wherein the weight ratio of the baicalein to the phospholipid is 1:1-6. The invention also discloses a preparation method of the baicalein phospholipid complex. The baicalein phospholipid complex prepared by the invention can improve the hydrophilicity and lipophilicity of the baicalein, and improve the bioavailability of the baicalein.

Description

technical field [0001] The invention relates to the technical field of medicine and its preparation, in particular to a flavonoid natural active product baicalein phospholipid complex and a preparation method thereof. Background technique [0002] Radix Scutellariae (Radix Scutellariae) is the dry root of Scutel-laria baicalensis Georgi, a plant in the Labiatae family. It is bitter in taste and cold in nature. Baicalein (Baicalein, BAI) is one of the main active ingredients of Scutellaria baicalensis, its chemical structure belongs to flavonoids, and its structural formula is as follows: [0003] [0004] Studies have shown that baicalein has the following pharmacological effects: 1. Antibacterial and antiviral; 2. Inhibiting inflammation; 3. Liver protection, choleretic and diuretic; 4. Free radical scavenging and antioxidant effects; 5. Anticoagulant and antithrombotic; 6 Inhibition of pancreatic enzyme activity; 7 The effect on biofilm; 8 Anti-cancer; 9 Dual regulatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/10C07D311/30
Inventor 金一张春燕王成润
Owner ZHEJIANG UNIV
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