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Anti-adhesion agent and preparation process thereof
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A technology of anti-adhesion agent and concentrated solution, which is applied in the field of medical materials and can solve the problems of high cost and fast degradation
Inactive Publication Date: 2010-06-02
李淳
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However, these products also have some disadvantages. For example, hyaluronic acid products are expensive and degrade too fast, especially when the wound surface contains blood, and its degradation products can promote adhesion; natural chitosan There are huge differences or even opposite effects on cells at different concentrations, especially for the regulation of many cells, which can promote the growth of one cell and inhibit the growth of another cell; while PLGA mainly acts as a physical barrier, Causes chronic inflammatory response that persists for several months after clinical use
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Embodiment 1
[0251] 1) Preparation of dilute solution
[0252] Prepare 4L of 9g / L sodium chloride solution, heat it to 80-90°C, and slowly add 20.0g of HPMC into it under stirring condition, at this time a white turbid suspension is formed, continue to stir, and it can be formed after the temperature drops Colorless and transparent solution.
[0253] 2) Concentration of dilute solution
[0254] Add 0.05% activated carbon (g / m1) to the above solution, stir for 10 minutes, filter to remove carbon, then filter the filtrate through a 0.8 μm microporous membrane, heat the filtrate to 90°C in a water bath, and keep it for 25 minutes to appear an obvious white colloidal precipitate , separate the precipitate from the liquid while hot. Pour the precipitate into a quantitative container and cool to room temperature to form a colorless, transparent, viscous concentrated solution.
[0268] Prepare 4L of 9g / L sodium chloride solution, heat it to 80-90°C, and slowly add 15.0g of HPMC to it while stirring, at this time a white turbid suspension is formed, continue to stir, and it can be formed after the temperature drops Colorless and transparent solution.
[0269] 2) Concentration of dilute solution
[0270] Add 0.03% activated carbon (g / ml) to the above solution, stir for 5 minutes, filter to remove carbon, and then filter the filtrate through a 0.8 μm microporous membrane. The filtrate was heated to 100°C in a water bath and kept for 15 minutes, so that an obvious white colloidal precipitate appeared, and the precipitate was separated from the liquid while it was hot. Pour the precipitate into a quantitative container and cool to room temperature to form a colorless, transparent, viscous concentrated solution.
[0271] 3) Detection of concentrated liquid
[0272] Adopt osmometer to measure the osmotic pressur...
Embodiment 3
[0283] 1) Preparation of dilute solution
[0284] Prepare 4L of 9g / L sodium chloride solution, heat it to 80-90°C, and slowly add 25.0g of HPMC into it under stirring conditions, at this time a white turbid suspension is formed, continue to stir, and it can be formed after the temperature drops Colorless and transparent solution.
[0285] 2) Concentration of dilute solution
[0286] Add activated carbon 0.07% (g / ml) to the above solution, stir for 20 minutes, filter to remove carbon, then filter the filtrate through a 0.8 μm microporous membrane, heat the filtrate to 80°C in a water bath, and keep it for 30 minutes, so that an obvious white gel appears. Precipitate, separate the precipitate from the liquid while hot. Pour the precipitate into a quantitative container and cool to room temperature to form a colorless, transparent, viscous concentrated solution.
[0287] 3) Detection of concentrated liquid
[0288] Adopt osmometer to measure the osmotic pressure of concentrat...
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Abstract
The invention discloses an anti-adhesion agent and a preparation process thereof. The preparation process comprises the following steps: firstly, preparing 8.5 to 11.7g / L solution of sodiumchloride, heating the sodiumchloride solution to 80 to 90 DEG C, adding hydroxy-propyl methyl cellulose into the solution of sodiumchloride, stirring the mixture, cooling the obtained product, adding active carbons into the obtained product, filtering the product, heating the filtrate to 80 to 100 DEG C, performing precipitation separation immediately, and then cooling precipitates to form a concentrated solution; testing an osmotic pressure A mOsmol / L , a concentration B percent, and a volume C (L) of the concentrated solution, preparing, a solution of sodium chloride with the concentration of (X B-0.06A) / (B-2)g / L, and adding the solution of sodium chloride into the concentrated solution to ensure that the osmotic pressure of the concentrated solution is between 260 mOsmol / L and 360mOsmol / L and a concentration of the HPMC is between 2 percent and 5 percent. The anti-adhesion agent has the advantages of safety and low cost, and has obvious effects of preventing the postoperative intestinal adhesion and pelvic adhesion after abdominal and pelvic operations of the general surgery, obstetrics and gynecology and the like, preventing the adhesion of tendon, joint and nerve operations, and preventing and treating traumatic or degenerative ostarthritis.
Description
technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a medical operation anti-adhesion agent and a preparation process thereof. Background technique [0002] Adhesions are abnormal structures where fibrous bands of connective tissue join together with adjacent tissues or organs. Tissue adhesion after surgery is a common clinical phenomenon, and its occurrence may lead to serious clinical complications. Foreign surveys have found that the incidence of adhesions in abdominal and pelvic surgery is 90%, 50% of which involve the intestinal tract and omentum, and 10% of cases develop adhesive intestinal obstruction within 1 year. After gynecological surgery, the incidence of pelvic adhesions exceeds 55%, which can lead to pelvic pain, infertility, etc. After plastic surgery, the formation of adhesions and scar tissue can easily lead to serious postoperative complications, such as tendon adhesions, peripheral nerve adhesions...
Claims
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Application Information
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