Method and nano balance for weighing viruses
A nano and virus technology, applied in the biological field, can solve the problems of long detection period, difficulty in H1N1 prevention and control, and high detection cost, and achieve the effects of convenient detection, easy operation and wide application range.
Inactive Publication Date: 2012-01-25
TIANJIN UNIV
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Problems solved by technology
However, the detection of H1N1 influenza virus by these two methods must be completed in a specific laboratory, the detection cost is high, and the detection cycle is long, which brings great difficulty to the prevention and control of H1N1
Method used
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Experimental program
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Effect test
Embodiment Construction
[0033] In the present invention, by means of photolithography process, the substrate (such as Si wafer, epitaxial SiO 2 Electrodes are prepared on Si wafers of oxide layers, etc., and not limited to substrate materials of such components, in which the critical dimension between the positive and negative electrodes is 1-10μm; the metal one-dimensional nanostructure (nanobelt, nanowire , Nanorods, etc., and are not limited to the morphologies mentioned above) to build between the positive and negative electrodes, (where the method of building one-dimensional nanostructures includes the self-growth of nanostructures between the positive and negative electrodes, and the synthesis of Nanomaterials are positioned and installed by micro-nano processing technology), the two ends of the metal one-dimensional nanostructure are respectively welded to the contact electrodes of the positive and negative electrodes (wherein the welding process can be processed by FIB equipment; AFM oxidation c...
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Abstract
The invention relates to a method for weighing viruses, belonging to the technical field of biology. The method is realized by preparing a nano balance and comprises the following steps of: preparing electrodes on a substratum through a photoetching process, wherein the dimension between the positive electrode and the negative electrode is 1-10 micrometers; constructing a metal one-dimensional nano structure between the positive electrode and the negative electrode; respectively welding both ends of the metal one-dimensional nano structure with contact electrodes of the positive electrode andthe negative electrode to realize ohmic contact, and constructing a scale, i.e. a cantilever beam of the nano balance, wherein the length of the cantilever beam is longer than or equal to 10 micrometers, the width of the cantilever beam is 150-500 micrometers, and the thickness of the cantilever beam is 10-90 micrometers; and after the cantilever beam loads the viruses, measuring the change of the vibration frequency of the cantilever beam by an optical astigmatism method so as to demarcate the weight of the viruses. The invention also relates to a nano range of the weighing method, the othermethod with same conception for weighing the viruses and the nano balance. The invention has simple process and convenient operation and can achieve accurate metering effect.
Description
Technical field [0001] The invention belongs to the field of biotechnology, and relates to a weighing device for rapid virus detection. Background technique [0002] In the field of international scientific research, certain basic work has been carried out on the measurement of the weight of a virus. However, there has not been any research report on the "nano scale" for weighing individual viruses, bacteria and microorganisms in China. There are still some laboratories and companies working on the research of grade cantilever beams, and the design of some metal cantilever beams is still in the laboratory simulation stage, and there is no staged work progress. [0003] Researchers from the Department of Medical Engineering of Purdue University in the United States claimed that the weight of the vaccinia virus in a smallpox vaccine was 9.5 femtograms (1 femtogram = one trillionth of a gram). The future research goal is to create a hand-held instrument that can monitor microorganism...
Claims
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IPC IPC(8): B81B7/02G01G19/00B81C1/00
Inventor 邹强倪恒侃傅星李玲霞张之圣王慧薛涛李付奎曹丽凤
Owner TIANJIN UNIV