Method for quickly detecting doping of benzodiazepine compound in food, medicine or health-care product

A medium benzodiazepine and detection method technology is applied in the field of rapid detection doped with benzodiazepines, and can solve the problem that the specific combination of a gold-labeled reagent and a test substance cannot be realized, and the colloidal gold immunity cannot be fully exerted. The advantages of chromatographic detection and the unknown amount of illegally adulterated benzodiazepines have achieved the effect of rapid screening, fast detection and low cost

Inactive Publication Date: 2010-06-02
广东省惠州市药品检验所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, the composition of food, medicine or health care products is very complex, the amount of illegal adulteration of benzodiazepines is unknown, and most of the food, medicine or health care products with sedative

Method used

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  • Method for quickly detecting doping of benzodiazepine compound in food, medicine or health-care product
  • Method for quickly detecting doping of benzodiazepine compound in food, medicine or health-care product
  • Method for quickly detecting doping of benzodiazepine compound in food, medicine or health-care product

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Embodiment 1 Yimengxiang Melatonin Capsules

[0045] The Yimengxiang Melatonin Capsules of this embodiment is a health food, and the dosage form is a capsule. First, prepare the test equipment:

[0046] Container with stopper (10ml), disposable filter, small glass bottle, benzodiazepine colloidal gold test paper.

[0047] The detection method of the present embodiment, its specific steps are as follows:

[0048] (1) Take 1 Yimengxiang melatonin capsule, open the capsule, pour the contents into a stoppered container, add 1ml of absolute ethanol, shake for 10 seconds, add water to make up the total volume to 10ml, put the stoppered container After the liquid in the filter is filtered, the filtrate is collected;

[0049] (2) Put the filtrate collected above into a small glass bottle, insert the benzodiazepine colloidal gold detection test paper into it, take out the test paper after 2 minutes, place it flat, and observe the color changes of the reaction line and the cont...

Embodiment 2 7

[0052] Example 2 Aescin Tablets

[0053] The Qiye Shen'an tablet of this embodiment is a Chinese patent medicine, and the dosage form is a tablet. First, prepare the test equipment:

[0054] Container with stopper (10ml), disposable filter, small glass bottle, benzodiazepine colloidal gold test paper, paper disc, pestle.

[0055] The detection method of the present embodiment, its specific steps are as follows:

[0056] (1) Take 1 Aescin tablet, put it on a piece of paper, grind it finely with a pestle, pour it into a container with a stopper, add 1ml of absolute ethanol, shake for 10 seconds, add water to make up the total volume to 10ml, and put the stopper After the liquid in the container is filtered, the filtrate is collected;

[0057] (2) Put the filtrate collected above into a small glass bottle, insert the benzodiazepine colloidal gold detection test paper into it, take out the test paper after 2 minutes, place it flat, and observe the color changes of the reaction l...

Embodiment 3 3

[0060] Embodiment 3 Sanshengbao sleeps in peace (sleeping tablet)

[0061] Sansheng Baoshui Er'an (Sleeping tablets) of the present embodiment is a health food, and its dosage form is a tablet. At first prepare the test equipment:

[0062] Container with stopper (10ml), disposable filter, small glass bottle, benzodiazepine colloidal gold test paper, paper disc, pestle.

[0063] The detection method of the present embodiment, its specific steps are as follows:

[0064] (1) Take 1 tablet of Sanshengbao Sleeper’an, put it on a piece of paper, grind it finely with a pestle, pour it into a stoppered container, add 1ml of absolute ethanol, shake for 10 seconds, add water to make up the total volume to 10ml, After filtering the liquid in the stoppered container, collect the filtrate;

[0065] (2) Put the filtrate collected above in a small glass bottle, put the filtrate in a small glass bottle, insert the benzodiazepine colloidal gold detection test paper into it, take out the test...

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Abstract

The invention discloses a method for quickly detecting the doping of a benzodiazepine compound in a food, a medicine or a health-care product. The method comprises the following steps: firstly, preprocessing a sample to be measured, extracting the benzodiazepine compound which is added in an enriched transgression way and then combining with a colloidal gold immunological chromatographic method, thereby realizing the quick detection of the benzodiazepine compound added into the food, the medicine or the health-care product.The invention features wide coverage range of measured targets, simple operation, high detection speed and easy observation of a detection result, can realize the quick screening of a large number of samples, picks out the samples added with the benzodiazepine compound in a transgression way from a large number of samples, lowers the cost greatly and reduces the workload.The preprocessing method can effectively enrich the concentration of a substance to be measured, so the detection result is more sensitive and accurate.The invention is suitable for various common medicament forms in the food, the medicine or the health-care product, can fill up a system screening method which is absent in the industry, executes the supervision and control over the food and medicine market effectively and guarantees the safety of the diet and medicine of people.

Description

technical field [0001] The invention relates to the detection field of food, medicine or health products, in particular to a rapid detection method for doping of benzodiazepine compounds in food, medicine or health products. Background technique [0002] With the increasingly fierce competition and increasing pressure in modern society, many people suffer from anxiety and depression, which induce sleep disorders and insomnia. Patients need to rely on drugs to relieve these symptoms. Commonly used drugs include diazepam (stable), alprazolam (jiajingan), estazolam, etc., which belong to the second class of psychotropic drugs, and their use is strictly restricted. For patients who need to take medicine for a long time, food with sedative and hypnotic effects, Chinese patent medicine or health food may become their first choice. [0003] Benzodiazepines (BZ) are commonly used clinical sedative and hypnotic drugs at present. It overcomes many shortcomings caused by barbiturates....

Claims

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Application Information

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IPC IPC(8): G01N33/558
Inventor 翁雪萍刘杜妙林暖丹李惠敏
Owner 广东省惠州市药品检验所
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