Eye drops containing recombinant human keratinocyte growth factor-2 and application thereof in treating xeroma

A technology of keratinocytes and growth factors, applied to medical preparations containing active ingredients, drug combinations, peptide/protein components, etc., can solve the problems of time-consuming, inconvenient, and not very effective in causing dry eye symptoms, and achieve the goal of using Convenience, improved stability, and increased action time

Inactive Publication Date: 2010-06-09
CHANGCHUN GROSTRE BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0003] At present, there is no particularly effective treatment method for dry eye syndrome. Instilling artificial tears is a common method, which can relieve the symptoms of dry eyes and eye astringency to a certain extent, but

Method used

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Examples

Experimental program
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Embodiment Construction

[0011] 1. Prescription Examples

[0012] 1. The formula of eye drops of the present invention: in 100ml, take 22.5mg of keratinocyte growth factor, 0.5mg of acetylated heparin glycoprotein sulfate, 1000mg of mannitol, 500mg of hydroxypropyl methylcellulose, 500mg of sodium chloride, and the rest It is 20mM citric acid and sodium citrate buffer, prepared according to the preparation method of the present invention.

[0013] 2. Eye drop formula of the present invention: in 100ml, get keratinocyte growth factor-25.0mg, acetylated heparin glycoprotein sulfate 1mg, mannitol 1500mg, hydroxypropyl methylcellulose 500mg, sodium chloride 300mg, the rest is 20mM citric acid and sodium citrate buffer, prepared according to the preparation method of the present invention.

[0014] 3. Eye drop formula of the present invention: in 100ml, get keratinocyte growth factor-27.0mg, acetylated heparin glycoprotein sulfate 20mg, mannitol 100mg, hydroxypropyl methylcellulose 500mg, sodium chloride ...

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PUM

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Abstract

The invention discloses eye drops with the function of relieving the symptom of xeroma, which are characterized by comprising a recombinant human keratinocyte growth factor-2, a protein protective agent, a thickening agent, an osmotic pressure regulator and a proper buffer system in a certain proportion; the invention also discloses a preparation method of the eye drops. Pharmacological experiments show that the eye drops can delay the rupture time of the lacrimal film, maintain the integrity of the ocular barrier, restore the ocular immunological network and relieve the symptom of the xeroma by restoring the corneal epithelium.

Description

technical field [0001] The invention relates to a recombinant human keratinocyte growth factor-2 eye drop and its application in the treatment of dry eye, especially suitable for repairing the corneal epithelium, delaying tear film rupture time, maintaining the integrity of the ocular surface barrier, repairing Ocular surface immune network to relieve dry eye symptoms. Background technique [0002] Dry eye refers to the abnormality of tear quality or quantity and dynamics caused by any reason, resulting in tear film instability and or abnormal ocular surface, accompanied by ocular symptoms. It is a common disease in ophthalmology. With the popularity and widespread use of computers, air conditioners, etc., the incidence of dry eye is increasing at an alarming rate, and the age tends to be younger. Severe dry eye will lead to corneal surface abrasion, filamentous keratitis and corneal ulcer, etc. And eventually lead to serious consequences such as corneal clouding and vision...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K38/18A61K47/42A61P27/02
Inventor 李校堃王晓杰田海山马吉胜
Owner CHANGCHUN GROSTRE BIOLOGICAL TECH
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