Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of docetaxel nanoparticle composition

A technology of docetaxel and composition, which is applied in the direction of drug combination, drug delivery, organic active ingredients, etc. It can solve the problems of low negative phospholipid content, high price, and health hazards for patients with cardiovascular and cerebrovascular diseases, and achieve high encapsulation efficiency , low price, and the effect of improving drug safety

Inactive Publication Date: 2012-02-08
CHIA TAI TIANQING PHARMA GRP CO LTD
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, pharmaceutical preparations containing more cholesterol may bring harm to the health of patients, especially those with cardiovascular and cerebrovascular diseases.
In addition, negative phospholipids are used in some liposomes, but the content of negative phospholipids in natural phospholipids is very small, the price is relatively high, and there is no pharmaceutical grade in China, which limits its clinical application

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of docetaxel nanoparticle composition
  • A kind of docetaxel nanoparticle composition
  • A kind of docetaxel nanoparticle composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036]Prescription: Docetaxel 1g

[0037] Hydrogenated Soy Lecithin 70g

[0038] 0.01NpH6.5 phosphate buffer (sodium dihydrogen phosphate or??, should be specific) 870ml

[0039] Preparation Process:

[0040] 1. Dissolve the prescription amount of docetaxel and hydrogenated soybean lecithin in 80ml of ethanol as the organic phase;

[0041] 2. Take 870ml of 0.01N pH6.5 phosphate buffer, heat it to 65°C and use it as the water phase;

[0042] 3. Slowly inject the organic phase into the water phase under nitrogen protection and stirring, and stir thoroughly for 30 minutes to obtain the nanoparticle suspension;

[0043] 4. Pass the nanoparticle suspension into a high-pressure homogenizer to homogenize for 5 times, then sterilize and filter, and pack aseptically.

Embodiment 2

[0045] Prescription: Docetaxel 1g

[0046] Egg yolk lecithin 30g

[0047] Sucrose 60g

[0048] Preparation Process:

[0049] 1. Dissolve the prescription amount of docetaxel and egg yolk lecithin in 22ml of ethanol as the organic phase;

[0050] 2. Take the prescribed amount of sucrose, add 230ml of water for injection to dissolve it as the water phase;

[0051] 3. Heat the water phase to 40°C at a constant temperature, slowly inject the organic phase into it under nitrogen protection and stirring, and shear for 30 minutes to obtain the nanoparticle suspension;

[0052] 4. Pass the nanoparticle suspension into a high-pressure homogenizer for homogenization 5 times, sterilize and filter, divide into vials for freeze-drying, and pack.

Embodiment 3

[0054] Prescription: Docetaxel 1g

[0055] Hydrogenated Soy Lecithin 25g

[0056] Soy Lecithin 15g

[0057] Maltose 45g

[0058] Preparation Process:

[0059] 1. Dissolve the prescription amount of docetaxel, hydrogenated soybean lecithin and soybean lecithin in 35ml ethanol as the organic phase;

[0060] 2. Take the prescribed amount of maltose, add 450ml of water for injection to dissolve it as the water phase;

[0061] 3. Heat the water phase to 70°C at a constant temperature, slowly inject the organic phase into it under nitrogen protection and stirring, and then shear for 20 minutes to obtain the nanoparticle suspension;

[0062] 4. Pass the nanoparticle suspension into the extruder and extrude it for 6 times, then sterilize and filter, put it into vials for freeze-drying, and pack.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle sizeaaaaaaaaaa
particle sizeaaaaaaaaaa
Login to View More

Abstract

The present invention relates to a docetaxel nanoparticle composition that can be used for injection administration and a preparation method thereof. The docetaxel nanoparticle composition of the present invention contains neutral phospholipid and docetaxel, and the composition does not contain negative phospholipid and cholesterol.

Description

technical field [0001] The invention relates to a composition which can be used for injection administration and a preparation method thereof, in particular to a docetaxel nanoparticle composition which can be used for injection administration and a preparation method thereof. Background technique [0002] Docetaxel (docetaxel, docetaxel) is a taxane compound, which can be obtained by semi-synthesis from the non-cytotoxic precursor compound 10-deacylated baccatin II extracted from Taxus chinensis, 1998 Approved by the US FDA for marketing, it is currently the most effective taxane anticancer agent in clinical use. Since its launch, it has been widely used in the treatment of various cancers, including prostate cancer, breast cancer, lung cancer, gastric cancer, head and neck tumors, etc. At present, docetaxel has become one of the most widely used cytotoxic drugs in the treatment of solid tumors. The main indications for marketed docetaxel are locally advanced or metastati...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K9/19A61K31/337A61P35/00
Inventor 张喜全张来芳程艳菊
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com