The invention discloses a method for preparing
matrine slow-release tablets by applying attapulgite, which comprises the following steps of: dissolving
matrine by using
hydrochloric acid with the
mass concentration of 0.1 percent to obtain 2-5mg / ml of
matrine solution; adsorbing the matrine solution through modified attapulgite for 4-6 hours according to the proportion by weight of 1:2; filtering and
drying to obtain the attapulgite loading the matrine; and adding 2 percent by weight of talcum
powder into the attapulgite loading the matrine, granulating by a dry method, and tabletting to obtain the matrine slow-release tablets. A modifying method of the attapulgite comprises the following steps of: weighing 20g of attapulgite, placing the attapulgite into 1000ml of
aqueous solution, stirring for 12 hours,
settling, removing upper water, adding
purified water, stirring for 12 hours,
settling, taking an intermediate fine particle layer, adding concentrated
hydrochloric acid,
settling for 24 hours, filtering through suction, washing with water to be neutral,
drying at the temperature of 105DEG C, finely
grinding and screening with a 120-mesh screen to obtain acid modified attapulgite. The invention adopts the principle of
adsorption separation and selects the modified attapulgite which can be taken as an adsorbent for adsorbing the matrine, the matrine slow-release tablets are slowly released under the
desorption action of a
body fluid, operation steps are simple, and the production period of
traditional Chinese medicine preparations is shortened.