Method for preparing matrine slow-release tablet by applying attapulgite
A technology of attapulgite and modified attapulgite, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, allergic diseases, etc., and can solve problems such as high cost, increased side effects, and complicated auxiliary materials, and achieve low production costs , short production cycle, and the effect of increasing added value
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Embodiment 1
[0017] Example 1: Weigh 20 g of attapulgite and place it in 1000 ml of aqueous solution, stir for 12 hours, let stand, pour off the upper layer of water, add purified water, stir for 12 hours, let stand, take the middle fine particle layer, add concentrated hydrochloric acid and let stand for 24 hours, Suction filtration, washing to neutrality, drying at 105°C, grinding, passing through a 120 mesh sieve to obtain acid-modified attapulgite; take 20 g of matrine, and dissolve it into a 2 mg / ml solution with hydrochloric acid with a mass concentration of 0.1%. Matrine solution was absorbed by 40g of acid-modified attapulgite for 4h, filtered, and vacuum-dried at 60°C to obtain attapulgite loaded with matrine; add 2% of its weight talcum powder to the attapulgite loaded with matrine Mix evenly, dry granulate, sieve and granulate, and tablet, making 100 tablets in total.
Embodiment 2
[0018] Example 2: Weigh 20 g of attapulgite and place it in 1000 ml of aqueous solution, stir for 12 hours, let stand, pour off the upper layer of water, add purified water, stir for 12 hours, let stand, take the middle fine particle layer, add concentrated hydrochloric acid and let stand for 24 hours, Suction filtration, washing to neutrality, drying at 105°C, fine grinding, and passing through a 120 mesh sieve to obtain acid-modified attapulgite; take 40 g of matrine, and dissolve it into a 3 mg / ml solution with hydrochloric acid with a mass concentration of 0.1%. The matrine solution was absorbed by 80 g of acid-modified attapulgite for 5 hours, filtered, and vacuum-dried at 60° C. to obtain attapulgite loaded with matrine; 2% of its weight of talcum powder was added to the attapulgite loaded with matrine Mix evenly, dry granulate, sieve and granulate, compress into tablets, and make 200 tablets in total.
Embodiment 3
[0019] Example 3: Weigh 20 g of attapulgite and place it in 1000 ml of aqueous solution, stir for 12 hours, let stand, pour off the upper layer of water, add purified water, stir for 12 hours, let stand, take the middle fine particle layer, add concentrated hydrochloric acid and let stand for 24 hours, Suction filtration, washing to neutrality, drying at 105°C, grinding finely, and passing through a 120 mesh sieve to obtain acid-modified attapulgite; take 40 g of matrine, and dissolve it into a 5 mg / ml solution with hydrochloric acid with a mass concentration of 0.1%. Matrine solution was absorbed by 80 g of acid-modified attapulgite for 6 hours, filtered, and vacuum-dried at 60°C to obtain matrine-loaded attapulgite; add 2% of its weight to the acid-modified attapulgite-loaded matrine The talc powder was mixed evenly, dry granulated, sieved and granulated, and compressed into tablets to make 200 tablets in total.
[0020] Content determination: Take a piece of sustained-relea...
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