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Method for preparing matrine slow-release tablet by applying attapulgite

A technology of attapulgite and modified attapulgite, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, allergic diseases, etc., and can solve problems such as high cost, increased side effects, and complicated auxiliary materials, and achieve low production costs , short production cycle, and the effect of increasing added value

Inactive Publication Date: 2011-06-15
HUAIYIN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinically used matrine preparations are mainly injections, which have a short elimination half-life. If they are made into ordinary tablets, they need to be taken orally 3 to 4 times a day. Reduced, bringing a lot of inconvenience to treatment and patients
The patent "Matrine Sustained-release Tablets and Its Preparation Method" with the authorized notification number CN1235584C, and the patent "Matrine Oral Sustained-release Tablets and Its Preparation Method" with the publication number CN1555797A all disclose the properties of Matrine Sustained-release Tablets. The preparation method, the methods used are common methods for sustained-release preparations, and the release rate of the active ingredient is controlled by the commonly used sustained-release matrix matrix material to achieve the purpose of sustained release. The excipients used in this process are complex and costly

Method used

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  • Method for preparing matrine slow-release tablet by applying attapulgite
  • Method for preparing matrine slow-release tablet by applying attapulgite
  • Method for preparing matrine slow-release tablet by applying attapulgite

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Example 1: Weigh 20 g of attapulgite and place it in 1000 ml of aqueous solution, stir for 12 hours, let stand, pour off the upper layer of water, add purified water, stir for 12 hours, let stand, take the middle fine particle layer, add concentrated hydrochloric acid and let stand for 24 hours, Suction filtration, washing to neutrality, drying at 105°C, grinding, passing through a 120 mesh sieve to obtain acid-modified attapulgite; take 20 g of matrine, and dissolve it into a 2 mg / ml solution with hydrochloric acid with a mass concentration of 0.1%. Matrine solution was absorbed by 40g of acid-modified attapulgite for 4h, filtered, and vacuum-dried at 60°C to obtain attapulgite loaded with matrine; add 2% of its weight talcum powder to the attapulgite loaded with matrine Mix evenly, dry granulate, sieve and granulate, and tablet, making 100 tablets in total.

Embodiment 2

[0018] Example 2: Weigh 20 g of attapulgite and place it in 1000 ml of aqueous solution, stir for 12 hours, let stand, pour off the upper layer of water, add purified water, stir for 12 hours, let stand, take the middle fine particle layer, add concentrated hydrochloric acid and let stand for 24 hours, Suction filtration, washing to neutrality, drying at 105°C, fine grinding, and passing through a 120 mesh sieve to obtain acid-modified attapulgite; take 40 g of matrine, and dissolve it into a 3 mg / ml solution with hydrochloric acid with a mass concentration of 0.1%. The matrine solution was absorbed by 80 g of acid-modified attapulgite for 5 hours, filtered, and vacuum-dried at 60° C. to obtain attapulgite loaded with matrine; 2% of its weight of talcum powder was added to the attapulgite loaded with matrine Mix evenly, dry granulate, sieve and granulate, compress into tablets, and make 200 tablets in total.

Embodiment 3

[0019] Example 3: Weigh 20 g of attapulgite and place it in 1000 ml of aqueous solution, stir for 12 hours, let stand, pour off the upper layer of water, add purified water, stir for 12 hours, let stand, take the middle fine particle layer, add concentrated hydrochloric acid and let stand for 24 hours, Suction filtration, washing to neutrality, drying at 105°C, grinding finely, and passing through a 120 mesh sieve to obtain acid-modified attapulgite; take 40 g of matrine, and dissolve it into a 5 mg / ml solution with hydrochloric acid with a mass concentration of 0.1%. Matrine solution was absorbed by 80 g of acid-modified attapulgite for 6 hours, filtered, and vacuum-dried at 60°C to obtain matrine-loaded attapulgite; add 2% of its weight to the acid-modified attapulgite-loaded matrine The talc powder was mixed evenly, dry granulated, sieved and granulated, and compressed into tablets to make 200 tablets in total.

[0020] Content determination: Take a piece of sustained-relea...

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Abstract

The invention discloses a method for preparing matrine slow-release tablets by applying attapulgite, which comprises the following steps of: dissolving matrine by using hydrochloric acid with the mass concentration of 0.1 percent to obtain 2-5mg / ml of matrine solution; adsorbing the matrine solution through modified attapulgite for 4-6 hours according to the proportion by weight of 1:2; filteringand drying to obtain the attapulgite loading the matrine; and adding 2 percent by weight of talcum powder into the attapulgite loading the matrine, granulating by a dry method, and tabletting to obtain the matrine slow-release tablets. A modifying method of the attapulgite comprises the following steps of: weighing 20g of attapulgite, placing the attapulgite into 1000ml of aqueous solution, stirring for 12 hours, settling, removing upper water, adding purified water, stirring for 12 hours, settling, taking an intermediate fine particle layer, adding concentrated hydrochloric acid, settling for 24 hours, filtering through suction, washing with water to be neutral, drying at the temperature of 105DEG C, finely grinding and screening with a 120-mesh screen to obtain acid modified attapulgite. The invention adopts the principle of adsorption separation and selects the modified attapulgite which can be taken as an adsorbent for adsorbing the matrine, the matrine slow-release tablets are slowly released under the desorption action of a body fluid, operation steps are simple, and the production period of traditional Chinese medicine preparations is shortened.

Description

technical field [0001] The invention relates to a preparation method of oral sustained-release tablets, in particular to a method for preparing matrine sustained-release tablets using attapulgite. Background technique [0002] Matrine is a tetracyclic quinolizidine alkaloid isolated from the leguminous plants Sophora flavescens Sophorae, broad bean root, etc. It can inhibit the replication of hepatitis B HbeAg, improve the symptoms and signs of pathological hepatitis, and fight cancer. , Anti-arrhythmia, anti-hepatic fibrosis, immunosuppression, anti-inflammation, anti-hypertensive vascular remodeling and other pharmacological effects. The clinically used matrine preparations are mainly injections, which have a short elimination half-life. If they are made into ordinary tablets, they need to be taken orally 3 to 4 times a day. Reduced, bring a lot of inconvenience to the treatment and patients. The patent "Matrine Sustained-release Tablets and Its Preparation Method" with ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61P9/06A61P1/16A61K31/4375A61P9/12A61K9/22A61P37/06A61P35/00A61K47/02A61P29/00
Inventor 尹秀莲游庆红固旭赵玉萍吴洁
Owner HUAIYIN INSTITUTE OF TECHNOLOGY
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