Meclofenoxate hydrochloride microcapsule and method for preparing injection thereof

A technology of meclofenxate hydrochloride and microcapsules, which are applied in the field of meclofenxate hydrochloride freeze-dried preparations and their preparation, can solve the problems of unsatisfactory effect, high cost, limited wide application and the like, and improve bioavailability. , slow release, reduce the effect of hydrolysis reaction

Inactive Publication Date: 2008-10-08
HAINAN LINGKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the production cycle of sterile packaging preparations is long, the cost is high, and the output of a single batch is small, thereby limiting the wide application of this product in clinical practice; the freeze-dried preparation is a freeze-dried powder prepared after

Method used

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  • Meclofenoxate hydrochloride microcapsule and method for preparing injection thereof
  • Meclofenoxate hydrochloride microcapsule and method for preparing injection thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0059] Example 1:

[0060] Meclofenoxate Hydrochloride 60g

[0061] Gelatin 180g

[0062] Dextran 150g

[0063] Span 20g

[0064] Poloxamer 20g

[0065] Preparation Process

[0066] (1) Add 60g of meclofenoxate hydrochloride to water for injection to completely dissolve;

[0067] (2) Add 180 g of gelatin and 20 g of Span to the solution obtained in step (1), and prepare a water-in-oil emulsion by a mechanical stirring method;

[0068] (3) Add 500 ml of 30% dextran solution and 20 g of poloxamer to the solution obtained in step (2), and prepare a water-in-oil-in-water double emulsion by a mechanical stirring method;

[0069] (4) Inject the double emulsion obtained in step (3) from the sharp hole into the potassium hydroxide solidified solution with a solubility of 3mol / L in the high-voltage electrostatic field, the electric field voltage is 2.2kv, and the injection speed is 5ml / min. After curing for 10 minutes, the microcapsules are filtered out, and the microcapsules are washed wi...

Example Embodiment

[0070] Example 2:

[0071] Meclofenoxate Hydrochloride 250g

[0072] Gelatin 800g

[0073] Dextran 300g

[0074] Egg yolk lecithin 100g

[0075] Polyoxyethylene hydrogenated castor oil 100g

[0076] Preparation Process

[0077] (1) Add 250g of meclofenoxate hydrochloride to water for injection to completely dissolve;

[0078] (2) Add 800 g of gelatin and 100 g of egg yolk lecithin to the solution obtained in step (1), and prepare a water-in-oil emulsion by a high-pressure homogenization method;

[0079] (3) Add 600 ml of 50% dextran solution and 100 g of polyoxyethylene hydrogenated castor oil to the solution obtained in step (2), and prepare a water-in-oil-in-water double emulsion by a high-pressure homogenization method;

[0080] (4) Inject the double emulsion obtained in step (3) from the orifice into the 6mol / L sodium ethoxide curing solution in the high-voltage electrostatic field, the electric field voltage is 4.4kv, and the injection speed is 20ml / min. After solidification ...

Example Embodiment

[0081] Example 3:

[0082] Meclofenoxate Hydrochloride 100g

[0083] Gelatin 250g

[0084] Dextran 180g

[0085] Soy Lecithin 50g

[0086] Hydrogenated soy lecithin 50g

[0087] Tween 80 50g

[0088] Polyoxyethylene stearate 50g

[0089] Preparation Process

[0090] (1) Add 100g of meclofenoxate hydrochloride to water for injection to completely dissolve;

[0091] (2) Add 250 g of gelatin, 50 g of soybean lecithin, and 50 g of hydrogenated soybean lecithin to the solution obtained in step (1), and prepare a water-in-oil emulsion by a mechanical stirring method;

[0092] (3) Add 600 ml of 30% dextran solution, 50 g of Tween 80 and 50 g of polyoxyethylene stearate to the solution obtained in step (2), and prepare a water-in-oil-in-water double emulsion by mechanical stirring;

[0093] (4) Inject the double emulsion obtained in step (3) from an orifice into the solidified solution of sodium hydroxide with a solubility of 5mol / L in the high-voltage electrostatic field, the electric fi...

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Abstract

The invention provides a meclofenoxate hydrochloride microcapsule for injection and a production method thereof. The meclofenoxate hydrochloride microcapsule for the injection is composed of the meclofenoxate hydrochloride and adjuvant, which is characterized in that the adjuvant contains gelatin, dextran and emulsifier. The invention also provides the production method of a meclofenoxate hydrochloride freeze-dry powder and injection. As the meclofenoxate hydrochloride microcapsule with high stability in water is used, the meclofenoxate hydrochloride is not hydrolyzed when redissolving; the clarity is good after redissolving; thereby a product in the invention has the advantages of good stability and good quality, which is good for storing the product for a long time.

Description

technical field [0001] The invention relates to a meclofenoxate hydrochloride microcapsule for injection and a preparation method thereof, and also relates to a meclofenoxate hydrochloride freeze-dried preparation and a preparation method thereof. It belongs to the field of medicine. Background technique [0002] Meclofenoxate hydrochloride was artificially synthesized by French scientist Professor Thuillier in 1957. Its chemical name is p-chlorophenoxyacetic acid dimethylaminoacetate. It is a central stimulant drug that has been used for many years. Oxygen, nervous disorder, and can control enuresis in children caused by deep sleep and low awakening alert point. In 1996, it was discovered that it can remove lipofuscin and free radicals in nerve cells, promote body metabolism, protect cell membranes, enhance memory and improve intelligence. It is called an activator of brain cell metabolism, which can promote the utilization of carbohydrates by brain cells. Increase the in...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K9/08A61K31/221A61K47/36A61P25/00
Inventor 邱民
Owner HAINAN LINGKANG PHARMA CO LTD
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