Method for synthesizing vitamin C sodium salt

A synthetic method and vitamin technology, applied in the direction of organic chemistry, can solve problems such as low esterification rate, unsatisfactory product color and quality, and long reaction time, so as to increase yield, shorten conversion reaction time, and prolong equipment service life Effect
CN101735183AActive Publication Date: 2010-06-16HEBEI WELCOME PHARMACEUTICAL CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HEBEI WELCOME PHARMACEUTICAL CO LTD
Publication Date
2010-06-16

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Abstract

The invention discloses a method for synthesizing vitamin C sodium salt which comprises the steps of: (a) mixing Gulonic acid with methanol solution, and orderly passing through a granular active carbon column and a cation resin column, (b) passing the treating fluid through a dry filter, (c) performing a recycle esterification reaction by passing the treating fluid acquired from the step b through the resin column so as to acquire esterified liquid, (d) pouring the esterified liquid into a constant pressure reactor and performing conversion reaction, and (e) cooling the liquid material B to room temperature after finishing the reaction and centrifuging so as to acquire the vitamin C sodium salt. The method of the invention efficiently promotes the esterifying ratio of products and the yield of the vitamin C sodium salt, shortens the conversion reaction time, simplifies the process, lowers the energy consumption and producing cost, decreases the environmental pollution and prolongs the service life of the device.
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Description

technical field

[0001] The invention relates to a synthesis method of organic compounds, in particular to a synthesis method of vitamin C sodium salt. Background technique

[0002] Vitamin C sodium salt (referred to as Vc-Na) is an important intermediate for the production of vitamin C by two-step fermentation. Its English name is Sodium L-Ascorbate, molecular formula: C 6 h 7 NaO 6 , molecular weight: 198.11. At present, the process of synthesizing vitamin C by the two-step fermentation method is usually to mix gulong acid and methanol according to a certain ratio, use concentrated sulfuric acid as a catalyst, and carry out methylation reaction at 60-70°C under normal pressure. After the methylation reaction is finished, cool the methylation reaction solution to 50-55°C, and add sodium bicarbonate which is the sum of the moles of gulonic acid and 1 / 2 the moles of concentrated sulfuric acid or 1 / 2 the moles of gulonic acid and 1 / 4 sodium carbonate of the sum of moles of...

Claims

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