Hepatitis E virus antigen, antigen composition thereof and kit comprising antigen or antigen composition and application thereof

A technology of hepatitis E virus and its composition, which is applied in the field of hepatitis virus antigen, can solve the problems of no commercial reagents, etc., and achieve the effects of high sensitivity, strong antigenicity and strong specificity
CN101735311BActive Publication Date: 2013-08-07NAT INST FOR FOOD & DRUG CONTROL +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NAT INST FOR FOOD & DRUG CONTROL
Publication Date
2013-08-07

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Abstract

The invention relates to a Hepatitis E virus antigen. The antigen has the following antigen fragments of: pS1-6, pS4-6, pS1-1 or pS4-1, wherein pS1-6 is a C tail end antigen of type 1 HEV ORF2 with a locus of 351-391 to 640-660aa; pS4-6 is the C tail end antigen of type 4 HEV ORF2 with a locus of 365-405 to 654-674aa; pS1-1 is an N tail end antigen of type 1 HEV ORF2 with a locus of 1-20 to 90-130aa; and pS4-1 is the N tail end antigen of type 4 HEV ORF2 with a locus of 1-20 to 104-144aa. The invention also relates to a composition comprising the antigen and a kit comprising the antigen or the antigen composition and application in detecting the Hepatitis E virus antigen. The Hepatitis E virus antigen provided by the invention has the advantages of strong antigen city and strong specificity. The kit provided by the invention and the application can detect an anti-HEV IgM antibody appearing in a sample as soon as possible so as to realize correct detection and diagnosis in the early period of HEV infection.
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Description

technical field

[0001] The present invention relates to a hepatitis virus antigen, in particular to a hepatitis E virus antigen, its antigen composition, and a kit and application containing the antigen or antigen composition. Background technique

[0002] HEV is a non-enveloped single-stranded positive-sense RNA virus with a genome length of about 7.2kb and three open reading frames (ORFs), which are non-coding regions (NCR), ORF1, ORF2, ORF3 and 3' UTR and PolyA tail. Among them, ORF3 overlaps with an amino acid at the C-terminus of ORF1 and part of the N-terminal amino acids of ORF2. ORF1 encodes 1690 amino acids, mainly non-structural proteins related to viral replication. ORF2 encodes 660 amino acids and is a structural protein of the virus. ORF3 encodes 123 amino acids, and its function is not yet clear. At present, the International Committee on Taxonomy of Viruses (ICTV) has not yet classified it accurately. Lu (Lu L, Li CH, Hagedorn.2006.Phylogenetic analysis o...

Claims

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