Synthetic method of effective component-royaljelly acid of royal jelly

A technology of effective components and synthesis methods, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of low coupling reaction yield, limited use, cumbersome synthesis routes, etc., to avoid difficulties in product purification , high yield and mild reaction conditions
CN101747181AInactive Publication Date: 2010-06-23邵阳市科瑞化学品有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
邵阳市科瑞化学品有限公司
Publication Date
2010-06-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a synthetic method of an effective component-royaljelly acid of royal jelly, comprising the following steps: allowing (1,1-bialkoxy-6-hexyl magnesiumhalide) to react with bromoethanol alkyl acid ester in the solvent in the presence of an auxiliary agent N-methyl-2-pyrrolidone under catalysis of catalytic amount of a copper catalyst; removing acetal protection under acid conditions to obtain 8-alkyl acyloxy caprylicaldehyde; and then adopting Knoevenagel condensation method to obtain the royaljelly acid in formula (1). The method adopted by the invention is characterized by mild reaction conditions, simple operation ('one pot method'), high yield and the like, and avoids the problems of difficult purification, low yield and the like encountered by the traditional synthetic technology of the compound, thus greatly reducing production cost. The reagent used in the whole reaction is available, thus being convenient for industrial implementation.
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Description

technical field

[0001] The invention relates to a method for preparing royal jelly acid. Background technique

[0002] Royal jelly acid, also known as royal jelly acid, its chemical name is trans-10-hydroxy-2-decenoic acid, the English name is trans-10-hydroxy-2-decenoic acid, referred to as 10-HAD, which is a unique component of royal jelly, and It is one of the main active ingredients of royal jelly. It can enhance the immune function of the body, strongly inhibit various cancer cells such as lymphoma and breast cancer, and can treat acute radiation damage and chemical damage at the same time. In view of the medical effect of royal jelly acid and its unique characteristics of royal jelly, the content of royal jelly acid has been used as the main index to measure the quality of royal jelly.

[0003] Now royal jelly acid is mainly obtained through two ways, one is extraction from royal jelly, and the other is chemical synthesis. Because the method for extracting royal jel...

Claims

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